Results 51 to 60 of about 334,109 (235)

Effect of RSK4 on biological characteristics of colorectal cancer

World Journal of Surgical Oncology, 2018
Background This study aimed to investigate the expression of P90 Ribosomal Protein S6 kinase 4 (RSK4) in colorectal cancer cells and its biological function.
Qingqing Ye, Xuan Wang, Min Jin, Meng Wang, Yan Hu, Shihu Yu, Yonghua Yang, Jiyuan Yang, Jun Cai   +8 more
doaj   +1 more source

Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents

Frontiers in Pharmacology, 2022
7-Ethyl-10-hydroxycamptothecin (SN38), a highly potent metabolite of irinotecan, has an anticancer efficacy 100–1000 folds more than irinotecan in vitro. However, the clinical application of SN38 has been limited due to the very narrow therapeutic window
Chao Yang, Chao Yang, Chao Yang, An-Jie Xia, Cheng-Hao Du, Ming-Xing Hu, You-Ling Gong, Rong Tian, Xin Jiang, Yong-Mei Xie   +9 more
doaj   +1 more source

Transcriptome Analysis of the Anti-Proliferative Effects of Ginsenoside Rh3 on HCT116 Colorectal Cancer Cells

Molecules, 2022
The mechanism of ginsenoside Rh3 activity against cancer remains unclear. This study aimed to investigate the underlying mechanism. The effects of Rh3 on the cell proliferation, migration and invasion, and cycle and apoptosis were analyzed using CCK-8 assay, transwell migration assay and flow cytometry, respectively. The RNA transcriptome was sequenced
Siying Teng, Xi Lei, Xinmin Zhang, Dongming Shen, Qiuyi Liu, Yingjie Sun, Yi Wang, Zhongyi Cong   +7 more
openaire   +3 more sources

Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo

PLoS ONE, 2012
Recently, histone deacetylase (HDAC) inhibitors have emerged as a promising class of drugs for treatment of cancers, especially subcutaneous T-cell lymphoma. In this study, we demonstrated that MPT0E028, a novel N-hydroxyacrylamide-derived HDAC inhibitor,
Hanhua Huang, Hsueh-Yun Lee, An-Chi Tsai, Chieh-Yu Peng, Mei-Jung Lai, Jing-Chi Wang, S. Pan, C. Teng, J. Liou   +8 more
semanticscholar   +1 more source

Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells

Frontiers in Oncology, 2021
Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic and epigenomic modifications.
Lorissa McDougall, Jui Thiang Brian Kueh, Jake Ward, Joel D. A. Tyndall, Joel D. A. Tyndall, Adele G. Woolley, Adele G. Woolley, Adele G. Woolley, Sunali Mehta, Sunali Mehta, Sunali Mehta, Cherie Stayner, David S. Larsen, Michael R. Eccles, Michael R. Eccles, Michael R. Eccles   +15 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Genetic variants in the calcium signaling pathway participate in the pathogenesis of colorectal cancer through the tumor microenvironment

Frontiers in Oncology, 2023
BackgroundCancer risk is influenced by calcium signaling in intracellular and intercellular signaling pathways. However, the relationship between the calcium signaling pathway and colorectal cancer risk remains unknown.
Jing-Yu Wu, Yu Shao, Chang-Zhi Huang, Zhen-Ling Wang, Hong-Qiang Zhang, Zan Fu   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell line

Journal of Genetic Engineering and Biotechnology, 2020
Colorectal cancer is common to both sexes; third in terms of morbidity and second in terms of mortality, accounting for 10% and 9.2% of cancer cases in men and women globally. Although drugs such as bevacizumab, Camptosar, and cetuximab are being used to
Fabian A. Ikwu, Yusuf Isyaku, B. Obadawo, H. A. Lawal, Samuel Akolade Ajibowu   +4 more
semanticscholar   +1 more source

Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways

Cell & Bioscience, 2019
Background More than the two decades, the question of whether vitamin D has a role in cancer frequency, development, and death has been premeditated in detail.
Suhail Razak, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan   +4 more
doaj   +1 more source