Results 91 to 100 of about 1,144,978 (368)

Structure and singly occupied molecular orbital analysis of anionic tautomers of guanine [PDF]

, 2008
Recently we reported the discovery of adiabatically bound anions of guanine which might be involved in the processes of DNA damage by low-energy electrons and in charge transfer through DNA.
Abdoul-Carime, Aflatooni, Aflatooni, Atkins, Bachorz, Berlin, Bixo, Boudaïffa, Cai, Cai, Carhart, Dolgounitcheva, Downs, Downs, Frisch, Gutowski, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Hendricks, Henkelman, Hert, Holliday, Humphrey, Kendall, Kendall, Li, Li, Mazurkiewicz, Messer, Periquet, Ptasinska, Sanville, Seidel, Straatsma, Taylor, Tonzani, Wesolowski, Willett, Zakjevskii   +42 more
core   +1 more source

Infinite products over visible lattice points

International Journal of Mathematics and Mathematical Sciences, 1994
About fifty new multivariate combinatorial identities are given, connected with partition theory, prime products, and Dirichlet series. Connections to Lattice Sums in Chemistry and Physics are alluded to also.
Geoffrey B. Campbell
doaj   +1 more source

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents

Molecules, 2011
We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CNS agents. Herein, we demonstrate, for the first time, student engagement from different sites around the globe in the development of new biologically ...
William L. Scott, Ziniu Zhou, Martin J. O’Donnell, Grzegorz Satała, Andrzej J. Bojarski, Jean Martinez, Gaël Nomezine, Maciej Pawłowski, Gilles Subra, Katarzyna Grychowska, Joanna Król, Paweł Zajdel   +11 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Rapid Discovery of Illuminating Peptides for Instant Detection of Opioids in Blood and Body Fluids

Molecules, 2019
The United States is currently experiencing an opioid crisis, with more than 47,000 deaths in 2017 due to opioid overdoses. Current approaches for opioid identification and quantification in body fluids include immunoassays and chromatographic methods (e.
Shabnam Jafari, Yann Thillier, Yousif H. Ajena, Diedra Shorty, Jiannan Li, Jonathan S. Huynh, Bethany Ming-Choi Pan, Tingrui Pan, Kit S. Lam, Ruiwu Liu   +9 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

Molecules, 2010
Amino acids are Nature’s combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins.
Martin J. O’Donnell, Maciej Pawłowski, Ziniu Zhou, Paweł Zajdel, William L. Scott   +4 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

Molecules, 2019
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries ...
David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi   +5 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source