Results 41 to 50 of about 53,849 (278)
Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]
, 2017 Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena +9 more
core +1 more source
Interactions of Cisplatin and Daunorubicin at the chromatin level [PDF]
, 2020 Unexpectedly, the widely used anticancer agents Cisplatin (Cis-Pt) and Daunorubicin (Dauno) exhibited cell type- and concentration-dependent synergy or antagonism in vitro.
Bacsó, Zsolt +7 more
core +2 more sources
International Journal of Scientific and Technological Research, 2019 Currently, humans and other living things can have many genotoxic damages due to reasons such as chemicals, drugs, unfavorable environmental effects. Breaks in the DNA structure due to genotoxic damage can cause mutations, changes in chromosome structure and cancer.
Cücer, Nurhan +3 more
openaire +3 more sources
The comet assay: topical issues [PDF]
Mutagenesis, 2008 The comet assay is a versatile and sensitive method for measuring single- and double-strand breaks in DNA. The mechanism of formation of comets (under neutral or alkaline conditions) is best understood by analogy with nucleoids, in which relaxation of DNA supercoiling in a structural loop of DNA by a single DNA break releases that loop to extend into a
A. R. Collins +7 more
openaire +4 more sources
The use of comet assay to assess global DNA methylation in human biomonitoring studies.
Frontiers in Genetics, 2015 The Comet assay is a valuable tool for the detection of DNA damage in genotoxicity and human biomonitoring studies. Throughout the years, this biomarker has undergone several adaptations in their protocol in order to increase its sensitivity and the ...
Carla Costa +2 more
doaj +1 more source
Herpes simplex virus-type1 (HSV-1) impairs DNA repair in cortical neurons [PDF]
, 2016 Several findings suggest that Herpes simplex virus-1 (HSV-1) infection plays a role in the neurodegenerative processes that characterize Alzheimer's disease (AD), but the underlying mechanisms have yet to be fully elucidated.
Alessio Cardinale +12 more
core +2 more sources
Toxoplasma gondii infection can induce retinal DNA damage:an experimental study
International Journal of Ophthalmology, 2014 AIM: To detect whether Toxoplasma gondii (T. gondii) infection of mice can induce retinal DNA damage.METHODS: A total of 20 laboratory-bred male Swiss albino mice were used and divided into four groups:control group (non-infected animals); T ...
Nagwa Mostafa El-Sayed, Eman Mohamed Aly
doaj +1 more source
Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1 [PDF]
, 2019 Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as ...
Beglov, Dmitri +12 more
core +7 more sources
Relationship between CpG and non-CpG DNA methylation in human lymphocytes assessed with comet assay [PDF]
The Ukrainian Biochemical JournalTissue-specific DNA methylation plays an important role in the regulation of many functional processes. The methylation level in single cells can be assessed using the comet assay (single-cell gel electrophoresis), a simple and cost-effective technique ...
M. Chopei +3 more
doaj +1 more source
Genes and Environment, 2021 Background The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue.
Haruna Tahara +3 more
doaj +1 more source