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The comet assay: ready for 30 more years.
Mutagenesis, 2018 During the last 30 years, the comet assay has become widely used for the measurement of DNA damage and repair in cells and tissues. A landmark achievement was reached in 2016 when the Organization for Economic Co-operation and Development adopted a comet
P. Møller
semanticscholar +1 more source
Comet assay and its use for evaluating oxidative DNA damage in some pathological states.
Physiological Research, 2019 The comet assay, or single-cell gel electrophoresis (SCGE), is a sensitive, rapid, relatively simple and inexpensive method for detecting DNA strand breaks in individual cells.
M. Kucharová +6 more
semanticscholar +1 more source
The use of comet assay to assess global DNA methylation in human biomonitoring studies.
Frontiers in Genetics, 2015 The Comet assay is a valuable tool for the detection of DNA damage in genotoxicity and human biomonitoring studies. Throughout the years, this biomarker has undergone several adaptations in their protocol in order to increase its sensitivity and the ...
Carla Costa +2 more
doaj +1 more source
Mutagenesis, 2018 Metallic nanoparticles (NPs) are promising nanomaterials used in different technological solutions as well as in consumer products. Silver (Ag), gold (Au) and platinum (Pt) represent three metallic NPs with current or suggested use in different ...
J. Lebedová +3 more
semanticscholar +1 more source
The comet assay in nanotoxicology research
Analytical and Bioanalytical Chemistry, 2010 Nanoscale particles can have impressive and useful characteristics, but the same properties may be problematic for human health. From this perspective it is critical to assess the ability of nanoparticles to cause DNA damage. This review focuses on the use of the comet assay in nanotoxicology research.
Karlsson, Hanna L.
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Reference cells and ploidy in the comet assay [PDF]
Frontiers in Genetics, 2015 In the comet assay single cells are analyzed with respect to their level of DNA damage. Discrimination of the individual cell or cell type based on DNA content, with concomitant scoring of the DNA damage, is useful since this may allow analysis of mixtures of cells.
Brunborg, Gunnar +4 more
openaire +6 more sources
Toxoplasma gondii infection can induce retinal DNA damage:an experimental study
International Journal of Ophthalmology, 2014 AIM: To detect whether Toxoplasma gondii (T. gondii) infection of mice can induce retinal DNA damage.METHODS: A total of 20 laboratory-bred male Swiss albino mice were used and divided into four groups:control group (non-infected animals); T ...
Nagwa Mostafa El-Sayed, Eman Mohamed Aly
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Genes and Environment, 2021 Background The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue.
Haruna Tahara +3 more
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The Comet Assay as a Tool to Detect the Genotoxic Potential of Nanomaterials
Nanomaterials, 2019 The interesting physicochemical characteristics of nanomaterials (NMs) has brought about their increasing use and, consequently, their increasing presence in the environment.
A. García-Rodríguez +6 more
semanticscholar +1 more source
The Comet Assay in Human Biomonitoring
, 2013 Human biomonitoring studies aim to identify potential exposures to environmental, occupational, or lifestyle toxicants in human populations and are commonly used by public health decision makers to predict disease risk. The Comet assay measures changes in genomic stability and is one of the most reliable biomarkers to indicate early biological effects ...
Anderson, Diana +2 more
openaire +5 more sources