Results 51 to 60 of about 809,787 (268)
Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations
Frontiers in Immunology, 2019 Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation.
Fernando Corvillo +11 more
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Immunological features of patients affected by Barraquer-Simons syndrome
Orphanet Journal of Rare Diseases, 2020 Background C3 hypocomplementemia and the presence of C3 nephritic factor (C3NeF), an autoantibody causing complement system over-activation, are common features among most patients affected by Barraquer-Simons syndrome (BSS), an acquired form of partial ...
Fernando Corvillo +13 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Haemolytic uremic syndrome: diagnosis and management [version 1; peer review: 3 approved]
F1000Research, 2019 The thrombotic microangiopathies (TMAs) are a group of diseases characterised by microangiopathic haemolysis, thrombocytopenia, and thrombus formation leading to tissue injury.
Neil S. Sheerin, Emily Glover
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Journal of Combinatorial Theory, Series A, 1973 AbstractA new proof is given for Haynsworth's formula for Schur's complement.
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
A cut above: atypical proteolysis endows complement C3 with non-canonical immune activities
The EMBO JournalWell-defined proteolysis of complement component 3 (C3) produces fragments that mediate its classic activities including target opsonization and phagocytosis. In this issue of The EMBO Journal, Demir et al, (2025) uncover a novel C3 fragment, C3-LHF1, in
Erin E West, Claudia Kemper
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Blood, 2016 In this issue of Blood , [Jodele et al][1][1][2] build upon earlier work on the role of complement in the pathophysiology[2][3] and therapy[3][4] of transplant-associated thrombotic microangiopathy (TA-TMA) by exploring genetic predisposition for developing this complication.
openaire +2 more sources