Results 11 to 20 of about 46,139 (228)

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19 [PDF]

Journal of Innate Immunity, 2022
Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the lectin complement pathway and has been suggested to be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). To study a possible association between MASP-2 and COVID-19, we aimed at developing a sensitive and reliable MASP-2 ELISA.
Götz, Maximilian Peter, Skjoedt, Mikkel-Ole, Bayarri-Olmos, Rafael, Hansen, Cecilie Bo, Pérez-Alós, Laura, Jarlhelt, Ida, Benfield, Thomas, Rosbjerg, Anne, Garred, Peter   +8 more
openaire   +4 more sources

Ex Vivo Test for Measuring Complement Attack on Endothelial Cells: From Research to Bedside

Frontiers in Immunology, 2022
As part of the innate immune system, the complement system plays a key role in defense against pathogens and in host cell homeostasis. This enzymatic cascade is rapidly triggered in the presence of activating surfaces.
Marie-Sophie Meuleman, Anna Duval, Véronique Fremeaux-Bacchi, Lubka T. Roumenina, Sophie Chauvet   +4 more
doaj   +1 more source

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct ...
Giselle Pidde-Queiroz, Fábio Carlos Magnoli, Fernanda C V Portaro, Solange M T Serrano, Aline Soriano Lopes, Adriana Franco Paes Leme, Carmen W van den Berg, Denise V Tambourgi   +7 more
doaj   +1 more source

Effects of Barranca yajiagengensis Powder in the Diet of Trachinotus ovatus on the Growth Performance, Antioxidant Capacity, Immunity and Morphology of the Liver and Intestine

Antioxidants, 2022
Barranca yajiagengensis, a novel filamentous microalga, can accumulate lutein under high-light and low-nitrogen conditions. It is well known that lutein has antioxidant, anti-inflammatory and immune-modulating properties.
Wei Zhao, Xin Cui, Zi-Qiao Wang, Rong Yao, Meng-Die Chen, Bao-Yan Gao, Cheng-Wu Zhang, Jin Niu   +7 more
doaj   +1 more source

Gene polymorphism of mannose-binding lectin-associated serine protease (MASP2) in indigenous populations of the Russian Arctic Territories

Инфекция и иммунитет, 2022
Mannose-binding lectin-associated serine proteases (MASP) are among of the key components in the lectin pathway (LP) of the complement activation. MASP-2 is the most studied agent among specific enzymes activating both mannose-binding lectin (MBL) and ...
Marina V. Smolnikova, M. A. Malinchik, S. Y. Tereschenko   +2 more
doaj   +1 more source

Apoptotic Changes, Oxidative Stress and Immunomodulatory Effects in the Liver of Japanese Seabass (Lateolabrax japonicus) Induced by Ammonia-Nitrogen Stress during Keep-Live Transport

Biology, 2023
This study investigated the effects of NH3-N on antioxidant responses, histoarchitecture, and immunity of Japanese seabass (Lateolabrax japonicus) during keep-live transport.
Meijie Guo, Qi Yan, Yixuan Dong, Zhaoyang Ding, Jun Mei, Jing Xie   +5 more
doaj   +1 more source

Activity of antioxidative defense enzymes in the blood of patients with liver echinococcosis [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Chronic echinococcocal disease is the parasite human disease caused by the penetration of larval (asexual) stages of the canine tapeworm (Echinococcus granulosus) in the liver of humans.
Lilić Aleksandar, Denčić Srđan, Pavlović Slađan Z., Blagojević Duško P., Spasić Mihajlo B., Stanković Nebojša S., Saičić Zorica S.   +6 more
doaj   +1 more source

Evaluation of Alpha-Ketoglutarate Supplementation on the Improvement of Intestinal Antioxidant Capacity and Immune Response in Songpu Mirror Carp (Cyprinus carpio) After Infection With Aeromonas hydrophila

Frontiers in Immunology, 2021
As an intermediate substance of the tricarboxylic acid cycle and a precursor substance of glutamic acid synthesis, the effect of alpha-ketoglutarate on growth and protein synthesis has been extensively studied.
Di Wu, Ze Fan, Jinnan Li, Yuanyuan Zhang, Chang’an Wang, Qiyou Xu, Liansheng Wang   +6 more
doaj   +1 more source

Consecutive enzyme cascades: complement activation at the cell surface triggers increased tissue factor activity [PDF]

Blood, 1990
Abstract Complement activation at the cell surface initiates cell damage through a series of reactions occurring at the cell membrane and, after assembly of the terminal membrane attack complex, produces leakage of cytoplasmic contents from the cell.
S D, Carson, D R, Johnson
openaire   +3 more sources

Platelets (thrombocytes): The other recognized functions [PDF]

Hospital Pharmacology, 2016
Introduction: Platelets are smallest blood cells of discoid or round shape and are cytoplasmic fragments of megakaryocytes. Platelets consist of 3 types of granules: alpha granules, dense granules and lysosomes.
Nikolić Ljubinka I., Vuković-Suvajdžić Nada D., Bugarinović Snežana M., Plećaš Darko V.   +3 more
doaj   +1 more source