Results 1 to 10 of about 610,671 (334)

Polyphosphates and Complement Activation [PDF]

Frontiers in Medicine, 2019
To sustain life in environments that are fraught with risks of life-threatening injury, organisms have developed innate protective strategies such that the response to wounds is rapid and localized, with the simultaneous recruitment of molecular ...
Edward M. Conway
doaj   +3 more sources

Complement Activation in Inflammatory Skin Diseases [PDF]

Frontiers in Immunology, 2018
The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria, viruses, and fungi. Activation of complement results in production of several molecules mediating
Jenny Giang, Marc A. J. Seelen, Martijn B. A. van Doorn, Robert Rissmann, Errol P. Prens, Jeffrey Damman   +5 more
doaj   +10 more sources

Urine complement analysis implies complement activation is involved in membranous nephropathy [PDF]

Frontiers in Medicine
BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear.
Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li   +5 more
doaj   +2 more sources

Complement Activation in Nephrotic Glomerular Diseases [PDF]

Biomedicines
The nephrotic syndrome holds significant clinical importance and is characterized by a substantial protein loss in the urine. Damage to the glomerular basement membrane or podocytes frequently underlies renal protein loss.
Dominik Nell, Robert Wolf, Przemyslaw Marek Podgorny, Tobias Kuschnereit, Rieke Kuschnereit, Thomas Dabers, Sylvia Stracke, Tilman Schmidt   +7 more
doaj   +2 more sources

Atypical Hemolytic Uremic Syndrome-Associated FHR1 Isoform FHR1*B Enhances Complement Activation and Inflammation

Frontiers in Immunology, 2022
Atypical hemolytic uremic syndrome (aHUS) is a rare but severe type of thrombotic microangiopathy that is triggered by the abnormal activation of the alternative complement pathway.
Boyang Xu, Yuqi Kang, Yujing Du, Weiyi Guo, Li Zhu, Hong Zhang   +5 more
doaj   +1 more source

Factors affecting IgG4-mediated complement activation

Frontiers in Immunology, 2023
Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system.
Nienke Oskam, Timon Damelang, Timon Damelang, Timon Damelang, Marij Streutker, Pleuni Ooijevaar-de Heer, Jan Nouta, Carolien Koeleman, Julie Van Coillie, Julie Van Coillie, Manfred Wuhrer, Gestur Vidarsson, Gestur Vidarsson, Theo Rispens   +13 more
doaj   +1 more source

Inside-Out of Complement in Cancer

Frontiers in Immunology, 2022
The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression.
Martin Kolev, Madhumita Das, Monica Gerber, Scott Baver, Pascal Deschatelets, Maciej M. Markiewski   +5 more
doaj   +1 more source

Quantitative detection of red blood cell antibody-mediated complement activation

Zhongguo shuxue zazhi, 2022
Objective To construct an in-vitro model of erythrocyte antibody-mediated complement activation, and establish quantitative detection methods based on flow cytometry and spectrophotometry, so as to explore the correlation of anti-body titers and ...
Zhongying WANG, Jian LI, Fengyong ZHAO, Chenrui QIAN, Wei SHEN, Liangfeng FAN, Sha JIN, Jiewei ZHENG, Yuyu ZHANG, Dong XIANG   +9 more
doaj   +1 more source

Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study

Platelets, 2022
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson, Marcus Ljungkvist, Myriam Martin, Anna M. Blom, Jenny Klintman, Ulf Schött, Eva Zetterberg, Thomas Kander   +7 more
doaj   +1 more source

Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus. [PDF]

, 2020
ObjectiveTo evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the ...
Alexander, Roberta Vezza, Arriens, Cristina, Collins, Christopher E, Dervieux, Thierry, Kalunian, Kenneth C, Massarotti, Elena M, Narain, Sonali, O'Malley, Tyler, Putterman, Chaim, Ramsey-Goldman, Rosalind, Saxena, Amit, Wallace, Daniel J, Weinstein, Arthur   +12 more
core   +2 more sources