Results 1 to 10 of about 4,342,004 (341)

Polyphosphates and Complement Activation [PDF]

Frontiers in Medicine, 2019
To sustain life in environments that are fraught with risks of life-threatening injury, organisms have developed innate protective strategies such that the response to wounds is rapid and localized, with the simultaneous recruitment of molecular ...
Edward M. Conway
doaj   +3 more sources

Complement activation in placental malaria [PDF]

Frontiers in Microbiology, 2015
Sixty percent of all pregnancies worldwide occur in malaria endemic regions. Pregnant women are at greater risk of malaria infection than their non-pregnant counterparts and are more likely to develop severe disease.
Chloe Ross McDonald, Vanessa eTran, Kevin Charles Kain   +2 more
doaj   +4 more sources

Pentraxins in Complement Activation and Regulation

Frontiers in Immunology, 2018
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self
Ying Jie Ma, Peter Garred
doaj   +2 more sources

Complement Activation in Inflammatory Skin Diseases

Frontiers in Immunology, 2018
The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria, viruses, and fungi. Activation of complement results in production of several molecules mediating
Jenny Giang, Marc A. J. Seelen, Martijn B. A. van Doorn, Robert Rissmann, Errol P. Prens, Jeffrey Damman   +5 more
doaj   +2 more sources

Urine complement analysis implies complement activation is involved in membranous nephropathy [PDF]

Frontiers in Medicine
BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear.
Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li   +5 more
doaj   +2 more sources

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

Science immunology, 2021
Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2 infection. However, it remains to be determined whether increased complement activation is a broad indicator of critical illness (and thus, no different in COVID-19).
Lina Ma, S. K. Sahu, M. Cano, V. Kuppuswamy, J. Bajwa, Ja’Nia McPhatter, A. Pine, Matthew L. Meizlish, George Goshua, C-Hong Chang, Hanming Zhang, C. Price, Parveen Bahel, H. Rinder, T. Lei, Aaron Day, D. Reynolds, Xiaobo Wu, Rebecca E. Schriefer, A. Rauseo, C. Goss, Jane A. O’Halloran, R. Presti, A. Kim, A. Gelman, Charles S. Dela Cruz, A. Lee, P. Mudd, H. Chun, J. Atkinson, H. Kulkarni   +30 more
semanticscholar   +2 more sources

The classical pathway triggers pathogenic complement activation in membranous nephropathy

Nature Communications, 2023
Membranous nephropathy (MN) is an antibody-mediated autoimmune disease characterized by glomerular immune complexes containing complement components. However, both the initiation pathways and the pathogenic significance of complement activation in MN are
Larissa Seifert, G. Zahner, C. Meyer-Schwesinger, Naemi C. Hickstein, S. Dehde, S. Wulf, Sarah M. S. Köllner, R. Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, O. Kretz, A. Borodovsky, S. Biniaminov, Yan-yan Wang, Hong Cheng, F. Koch-Nolte, P. Zipfel, H. Hopfer, Victor G. Puelles, U. Panzer, T. Huber, T. Wiech, N. Tomas   +23 more
semanticscholar   +1 more source

Atypical Hemolytic Uremic Syndrome-Associated FHR1 Isoform FHR1*B Enhances Complement Activation and Inflammation

Frontiers in Immunology, 2022
Atypical hemolytic uremic syndrome (aHUS) is a rare but severe type of thrombotic microangiopathy that is triggered by the abnormal activation of the alternative complement pathway.
Boyang Xu, Yuqi Kang, Yujing Du, Weiyi Guo, Li Zhu, Hong Zhang   +5 more
doaj   +1 more source

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

Frontiers in Immunology, 2021
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe ...
Youssif M. Ali, Matteo Ferrari, N. Lynch, S. Yaseen, T. Dudler, Sasha Gragerov, G. Demopulos, J. Heeney, W. Schwaeble   +8 more
semanticscholar   +1 more source

A Review of Complement Activation in SLE

Current Rheumatology Reports, 2021
Purpose of Review Complement activation is a key event in the pathogenesis of tissue inflammation and injury in systemic lupus erythematosus (SLE). This review is aimed at comparing the usefulness of measurement of complement proteins in serum/plasma (C3,
A. Weinstein, R. Alexander, D. Zack
semanticscholar   +1 more source