Results 1 to 10 of about 325,802 (246)

Polyphosphates and Complement Activation [PDF]

Frontiers in Medicine, 2019
To sustain life in environments that are fraught with risks of life-threatening injury, organisms have developed innate protective strategies such that the response to wounds is rapid and localized, with the simultaneous recruitment of molecular ...
Edward M. Conway
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Complement activation in placental malaria [PDF]

Frontiers in Microbiology, 2015
Sixty percent of all pregnancies worldwide occur in malaria endemic regions. Pregnant women are at greater risk of malaria infection than their non-pregnant counterparts and are more likely to develop severe disease.
Chloe Ross McDonald, Vanessa eTran, Kevin Charles Kain   +2 more
doaj   +4 more sources

Urine complement analysis implies complement activation is involved in membranous nephropathy [PDF]

Frontiers in Medicine
BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear.
Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li   +5 more
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Atypical Hemolytic Uremic Syndrome-Associated FHR1 Isoform FHR1*B Enhances Complement Activation and Inflammation

Frontiers in Immunology, 2022
Atypical hemolytic uremic syndrome (aHUS) is a rare but severe type of thrombotic microangiopathy that is triggered by the abnormal activation of the alternative complement pathway.
Boyang Xu, Yuqi Kang, Yujing Du, Weiyi Guo, Li Zhu, Hong Zhang   +5 more
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Factors affecting IgG4-mediated complement activation

Frontiers in Immunology, 2023
Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system.
Nienke Oskam, Timon Damelang, Timon Damelang, Timon Damelang, Marij Streutker, Pleuni Ooijevaar-de Heer, Jan Nouta, Carolien Koeleman, Julie Van Coillie, Julie Van Coillie, Manfred Wuhrer, Gestur Vidarsson, Gestur Vidarsson, Theo Rispens   +13 more
doaj   +1 more source

Inside-Out of Complement in Cancer

Frontiers in Immunology, 2022
The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression.
Martin Kolev, Madhumita Das, Monica Gerber, Scott Baver, Pascal Deschatelets, Maciej M. Markiewski   +5 more
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Quantitative detection of red blood cell antibody-mediated complement activation

Zhongguo shuxue zazhi, 2022
Objective To construct an in-vitro model of erythrocyte antibody-mediated complement activation, and establish quantitative detection methods based on flow cytometry and spectrophotometry, so as to explore the correlation of anti-body titers and ...
Zhongying WANG, Jian LI, Fengyong ZHAO, Chenrui QIAN, Wei SHEN, Liangfeng FAN, Sha JIN, Jiewei ZHENG, Yuyu ZHANG, Dong XIANG   +9 more
doaj   +1 more source

Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study

Platelets, 2022
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson, Marcus Ljungkvist, Myriam Martin, Anna M. Blom, Jenny Klintman, Ulf Schött, Eva Zetterberg, Thomas Kander   +7 more
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Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS

Intensive Care Medicine Experimental, 2019
Background The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS).
Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz, Wim K. Lagrand   +6 more
doaj   +1 more source

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Clinical & Translational Immunology, 2023
Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius   +14 more
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