Results 101 to 110 of about 638,552 (336)

Complement activation in IgA nephropathy

Kidney International, 1987
Activation of alternative complement pathway is presumed to be important pathogenically in IgA nephropathy since renal biopsies usually exhibit glomerular deposition of C3 and P (properdin). Surprisingly, little is known about plasma complement activation in this disease, and the plasma C3 and C4 concentrations are usually normal or increased.
John G. Curd, Bruce A. Julian, Nobuo Negoro, Sandra Sugimoto, Robert J. Wyatt, Yoshiharu Kanayama, Edmund C. Hudson   +6 more
openaire   +3 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Complement activation in human prion disease

Neurobiology of Disease, 2004
The central event in the neuropathological process of prion diseases (PrD) is the accumulation of abnormal prion protein accompanied by severe neuronal loss.
Gabor G Kovacs, Philippe Gasque, Thomas Ströbel, Elisabeth Lindeck-Pozza, Michaela Strohschneider, James W Ironside, Herbert Budka, Marin Guentchev   +7 more
doaj   +1 more source

P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model

Mediators of Inflammation, 2020
P-MAPA is a complex compound, derived from Aspergillus oryzae cultures, that has shown immunomodulatory properties in infection and cancer animal models.
Mariana Torrente Gonçalves, Carla Cristina Squaiella-Baptistão, Giselle Pidde, Priscila Hess Lopes, Iseu da Silva Nunes, Denise V. Tambourgi   +5 more
doaj   +1 more source

HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis [PDF]

, 2017
Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.
Borjabad, Alejandra, Chao, Wei, Emdad, Luni, Fisher, Paul B., Morgello, Susan, Murray, Jacinta, Nitkiewicz, Jadwiga, Potash, Mary Jane, Volsky, David J.   +8 more
core   +2 more sources

Nanoporesize affects complement activation

Journal of Biomedical Materials Research Part A, 2008
AbstractIn the present study, we have shown the vast importance of biomaterial nanotexture when evaluating inflammatory response. For the first time in an in vitro whole blood system, we have proven that a small increase in nanoporesize, specifically 180 nm (from 20 to 200 nm), has a huge effect on the complement system.
Ferraz, Natalia, Nilsson, Bo, Hong, Jaan, Karlsson Ott, Marjam   +3 more
openaire   +5 more sources

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Editorial: The complement system in autoimmunity

Frontiers in Immunology, 2022
Eveline Y. Wu, Eveline Y. Wu, Jessy J. Alexander, Shoichi Fukui, Shoichi Fukui, Shoichi Fukui, Shoichi Fukui   +6 more
doaj   +1 more source

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

The versatile functions of complement C3-derived ligands [PDF]

, 2016
The complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self-structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several ...
Ahearn, Altieri, Andrews, Arvieux, Aubry, Baiu, Bajtay, Bajtay, Barro, Baudino, Bellinger-Kawahara, Berger, Beyer, Bohnsack, Bretscher, Cabec, Cardone, Carroll, Carroll, Carroll, Carter, Carter, Castro, Chen, Chen, Colten, Corbi, Cravedi, Daha, Dempsey, Diamond, Ehirchiou, Erdei, Erdei, Erdei, Erdei, Erdei, Ezekowitz, Fearon, Fingeroth, Flick, Frade, Gadjeva, Georgakopoulos, Ghannam, Ghebrehiwet, Gros, Gupta, Han, Heeger, Helmy, Holers, Hynes, Iida, Illges, Ingalls, Isaak, Jacobson, Jozsi, Karnchanaphanurach, Kemper, Kerekes, Kerekes, Kerekov, Klos, Kooten, Kremlitzka, Kuraya, Kurtz, Law, Law, Li, Li, Liddington, Lu, Luxembourg, Maison, Marquart, Marquart, Matsumoto, Melchers, Miller, Miller, Mitchell, Mold, Molina, Morelli, Mueller-Ortiz, Nelson, Nemerow, Nicolaou, Nielsen, Ogembo, Olesen, Oliva, Pantazis, Papp, Patel, Pepys, Peyron, Pliyev, Postigo, Praz, Prechl, Prechl, Prieto, Prodeus, Puentes, Ramos, Raposo, Reis, Renzo, Ross, Rubtsov, Sacks, Sandor, Sandor, Schlesinger, Schmidt, Sim, Sim, Singh-Jasuja, Sissons, Skoberne, Sohn, Strainic, Strijp, Tan, Tedder, Thacker, Torok, Torok, Touw, Tsokos, Tsokos, Tsokos, Tuveson, Ueda, Ugarova, Verbovetski, Villiers, Wagner, Watry, Wehr, Weiss, White, Wilson, Wright, Yan, Zaffran, Zhang, Zhou, Zhou   +152 more
core   +2 more sources