Role of the complement system in the tumor microenvironment
Cancer Cell International, 2019 The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (
Ronghua Zhang +4 more
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Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
Phases of active matter in two dimensions [PDF]
arXiv, 2018 These notes focus on the description of the phases of matter in two dimensions. Firstly, we present a brief discussion of the phase diagrams of bidimensional interacting passive systems, and their numerical and experimental measurements. The presentation will be short and schematic.
arxiv
PARTIAL BIOCHEMICAL CHARACTERIZATION OF THE ACTIVATED ESTERASE REQUIRED IN THE COMPLEMENT-DEPENDENT CHEMOTAXIS OF RABBIT POLYMORPHONUCLEAR LEUKOCYTES [PDF]
, 1967 Elmer L. Becker, Peter A. Ward
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FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Complement Activation in Semisolid Media: Insolubilization of Alternative Pathway Convertases in Agar Gels with C3 Nephritic Factor-Containing Sera [PDF]
, 1977 Mohammed A. Arnaout +3 more
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Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
The mechanism of action of the C3b inactivator (conglutinogen- activating factor) on its naturally occurring substrate, the major fragment of the third component of complement (C3b) [PDF]
, 1975 JD Gitlin, F S Rosen, P J Lachmann
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FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source
Complementing Carbon Credits from Forest-Related Activities with Biodiversity Insurance and Resilience Value [PDF]
arXivCarbon credits are a key component of most national and organizational climate strategies. Financing and delivering carbon credits from forest-related activities faces multiple risks at the project and asset levels. Financial mechanisms are employed to mitigate risks for investors and project developers, complemented by non-financial measures such as ...
arxiv