Results 191 to 200 of about 4,342,004 (341)

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Directed-Complement Activation as a Novel Immunotherapeutic Approach for HER2-Breast Cancer. [PDF]

Immunotargets Ther
Seguin-Devaux C, Brandus B, Plesseria JM, Iserentant G, Servais JY, Pitiot A, Kanli G, Behrmann I, Schober R, Zimmer J, Cohen JHM, Dervillez X.   +11 more
europepmc   +1 more source

Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases [PDF]

, 2016
Sofia Mortensen, Jan K. Jensen, G.R. Andersen   +2 more
openalex   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Breaking the cycle: immune complexes, complement activation, and novel immunotherapies in lupus nephritis. [PDF]

Front Immunol
Dong C, Wu M, Liu H, Yang K, Ma S, Guo Y, Lan Y, Lu X.   +7 more
europepmc   +1 more source

A NOVEL MODELING APPROACH TO ELUCIDATE THE ROLE OF AUTOANTIBODIES IN COMPLEMENT ACTIVATION IN SLE [PDF]

David S. Pisetsky, Yangbing Zhao, Matthew Engelhard, Amanda M. Eudy, Philip M. Tedeschi, Alex Verdone, Megan E. B. Clowse, Lisa Criscione‐Schreiber, Jayanth Doss, Mithu Maheswaranathan, Rebecca E. Sadun, Jennifer L Rogers   +11 more
openalex   +1 more source

Complement activation in patients with diabetic nephropathy.

Diabetes & Metabolism, 2019
Xiao Li, D. Chang, Min Chen, M. Zhao
semanticscholar   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Alternative pathway-mediated tubular complement activation in human proteinuric kidney diseases: a proof-of-concept study. [PDF]

Clin Kidney J
Alkaff FF, Lammerts RGM, Tiller G, van den Heuvel MC, Bajema IM, Daha MR, van den Born J, Berger SP.   +7 more
europepmc   +1 more source

Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome

, 2009
Dorothea Orth‐Höller, Abdul Basit Khan, Asma Naim, Katharina Grif, Jens Brockmeyer, Helge Karch, Michael Joannidis, Simon J. Clark, Anthony J. Day, Sonja Fidanzi, Heribert Stoiber, Manfred P. Dierich, Lothar Bernd Zimmerhackl, Reinhard Würzner   +13 more
openalex   +2 more sources