Results 21 to 30 of about 4,342,004 (341)

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Journal of Infectious Diseases, 2020
Background Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate.
Aline H. de Nooijer, I. Grondman, N. Janssen, M. Netea, L. Willems, F. L. van de Veerdonk, E. Giamarellos‐Bourboulis, E. Toonen, L. Joosten, M. Jaeger, H. Dijkstra, H. Lemmers, L. van Emst, K. Schraa, C. Jacobs, A. Hijmans, Trees Jansen, Fieke Weren, Liz Fransman, Jelle Gerretsen, Josephine S. van de Maat, Gerine Nijman, S. Moorlag, E. Taks, P. Debisarun, I. Kouijzer, H. Wertheim, J. Hopman, J. Rahamat-Langendoen, C. Bleeker‐Rovers, J. ten Oever, R. van Crevel, J. Hoogerwerf, Q. de Mast, H. van der Hoeven, P. Pickkers, M. Kox, T. Frenzel, J. Schouten, Pleun Hemelaar, R. Beunders, S. van der Velde, E. Kooistra, Nicole J. B. Waalders, W. Claassen, Hidde Heesakkers, T. van Schaik, Hetty van der Eng, N. Rovers, Margreet Klop-Riehl   +49 more
semanticscholar   +1 more source

Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS

Intensive Care Medicine Experimental, 2019
Background The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS).
Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz, Wim K. Lagrand   +6 more
doaj   +1 more source

Dysregulation of Complement Activation and Placental Dysfunction: A Potential Target to Treat Preeclampsia?

Frontiers in Immunology, 2020
Preeclampsia is one of the leading causes of maternal and neonatal mortality and morbidity worldwide, affecting 2–8% of all pregnancies. Studies suggest a link between complement activation and preeclampsia.
E. Pierik, J. Prins, H. van Goor, G. Dekker, M. Daha, M. Seelen, S. Scherjon   +6 more
semanticscholar   +1 more source

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Clinical & Translational Immunology, 2023
Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius   +14 more
doaj   +1 more source

Complement Activation Problem [PDF]

Definitions, 2020
openaire   +2 more sources

Antibody‐mediated complement activation in pathology and protection

Immunology and Cell Biology, 2020
Antibody‐dependent complement activity is associated not only with autoimmune morbidity, but also with antitumor efficacy. In infectious disease, both recombinant monoclonal antibodies and polyclonal antibodies generated in natural adaptive responses can
Benjamin S. Goldberg, M. Ackerman
semanticscholar   +1 more source

Systemic complement activation in age-related macular degeneration. [PDF]

PLoS ONE, 2008
Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of
Hendrik P N Scholl, Peter Charbel Issa, Maja Walier, Stefanie Janzer, Beatrix Pollok-Kopp, Florian Börncke, Lars G Fritsche, Ngaihang V Chong, Rolf Fimmers, Thomas Wienker, Frank G Holz, Bernhard H F Weber, Martin Oppermann   +12 more
doaj   +1 more source

Overcoming Nanoparticle-Mediated Complement Activation by Surface PEG-Pairing.

Nano letters (Print), 2020
Surface PEGylation is a widely used strategy for nanoparticle camouflaging against recognition by the body's defenses in the blood and thus improving their deposition in diseased tissues.
Martina Pannuzzo, S. Esposito, Lin-Ping Wu, J. Key, Santosh Aryal, C. Celia, L. di Marzio, S. Moghimi, P. Decuzzi   +8 more
semanticscholar   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
doaj   +1 more source