Results 21 to 30 of about 427,983 (270)
Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria
Frontiers in Immunology, 2021 Antibody immunity against malaria is effective but non-sterile. In addition to antibody-mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated complement activation is also important in defense against infection ...
Dilini Rathnayake +2 more
doaj +1 more source
Using animal models to determine the significance of complement activation in Alzheimer's disease
Journal of Neuroinflammation, 2004 Complement inflammation is a major inflammatory mechanism whose function is to promote the removal of microorganisms and the processing of immune complexes.
Loeffler David A
doaj +1 more source
Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond
Frontiers in Immunology, 2020 The complement cascade was identified over 100 years ago, yet investigation of its role in pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal interface prevent inappropriate complement activation to protect the ...
Guillermina Girardi +3 more
doaj +1 more source
Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses
Viruses, 2021 The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah +5 more
doaj +1 more source
Modern view on the complement system role in membranous nephropathy
Терапевтический архив, 2022 Membranous nephropathy (MN), an immune-mediated glomerular disease, is the most common cause of adult nephrotic syndrome. In MN, proteinuria is developed by podocyte damage due to the complement system activation in response to the subepithelial ...
Elena S. Kamyshova +2 more
doaj +1 more source
How Can We Develop Explainable Systems? Insights from a Literature Review and an Interview Study [PDF]
, 2022 Quality aspects such as ethics, fairness, and transparency have been proven to be essential for trustworthy software systems. Explainability has been identified not only as a means to achieve all these three aspects in systems, but also as a way to foster users' sentiments of trust.
arxiv +1 more source
Frontiers in Immunology, 2018 Background: Bullous pemphigoid is a subepidermal blistering skin disease, associated with autoantibodies to hemidesmosomal proteins, complement activation at the dermal-epidermal junction, and dermal granulocyte infiltration.
Roxana M. Chiorean +9 more
doaj +1 more source
Neural Activation Patterns (NAPs): Visual Explainability of Learned Concepts [PDF]
arXiv, 2022 A key to deciphering the inner workings of neural networks is understanding what a model has learned. Promising methods for discovering learned features are based on analyzing activation values, whereby current techniques focus on analyzing high activation values to reveal interesting features on a neuron level.
arxiv
Coloring Deep CNN Layers with Activation Hue Loss [PDF]
arXiv, 2023 This paper proposes a novel hue-like angular parameter to model the structure of deep convolutional neural network (CNN) activation space, referred to as the {\em activation hue}, for the purpose of regularizing models for more effective learning. The activation hue generalizes the notion of color hue angle in standard 3-channel RGB intensity space to $
arxiv
Complement Activation and Inhibition in Wound Healing
Clinical and Developmental Immunology, 2012 Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore,
Gwendolyn Cazander +2 more
doaj +1 more source