Results 21 to 30 of about 576,913 (240)

Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits [PDF]

, 1999
Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage.
Goetz, Alwin Eduard, Groh, Joachim, Kiefmann, Rainer, Kuebler, Wolfgang M., Kuhnle, Gerhard E. H., Sckell, Axel   +5 more
core   +1 more source

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings [PDF]

, 2011
Characterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or ...
Apic G., Barlow P. N., Barlow P. N., Bernadó P., Bertini I., Bertini I., Bertini I., Bork P., Chen K., Clore G. M., Clore G. M., Clore G. M., Cornilescu G., Delaglio F., DiScipio R. G., Ekman D., Fernando A. N., Ferreira V. P., Furtado P. B., Garrett D. S., Gordon D. L., Henderson C. E., Hocking H. G., Hoebe K., Hourcade D., Janssen B. J. C., Kirkitadze M. D., Kirkitadze M. D., Kirkitadze M. D., Kirkitadze M. D., Lachmann P. J., Lakomek N.-A., Laskowski R. A., Lipari G., Litman G. W., Longinetti M., Losonczi J., Mateusz Maciejewski, McRee D. E., Meiler J., Morgan H. P., Nico Tjandra, Norman D. G., Okemefuna A. I., Okemefuna A. I., Ottiger M., Paul N. Barlow, Reid K., Ricklin D., Schmidt C. Q., Schwieters C. D., Schwieters C. D., Soares D. C., Soares D. C., Tjandra N., Tolman J. R., Ulrich E. L., Vranken W. F., Walport M. J., Weisman H. F., Wu J.   +60 more
core   +1 more source

Structural insights on complement activation [PDF]

The FEBS Journal, 2015
The proteolytic cleavage of C3 to generate C3b is the central and most important step in the activation of complement, a major component of innate immunity. The comparison of the crystal structures of C3 and C3b illustrates large conformational changes during the transition from C3 to C3b.
Alcorlo, Martín, López-Perrote, Andrés, Delgado, Sandra, Yébenes, Hugo, Subías, Marta, Rodríguez-Gallego, César, Rodríguez de Córdoba, Santiago, Llorca, Óscar   +7 more
openaire   +4 more sources

Pentraxins in Complement Activation and Regulation [PDF]

Frontiers in Immunology, 2018
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin.
Ma, Ying Jie, Garred, Peter
openaire   +5 more sources

Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells [PDF]

, 2009
Intrarenal complement activation plays an important role in the progression of chronic kidney disease. A key target of the activated complement cascade is the proximal tubule, a site where abnormally filtered plasma proteins and complement factors ...
Abbate, Mauro, Buelli, Simona, Moioli, Daniela, Morigi, Marina, Noris, Marina, Pusey, Charles D., Remuzzi, Giuseppe, Zanchi, Cristina, Zipfel, Peter F., Zoja, Carla   +9 more
core   +1 more source

Complement and platelets : prothrombotic cell activation requires membrane attack complex-induced release of danger signals [PDF]

, 2023
Complement activation in the diseases paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) results in cytolysis and fatal thrombotic events, which are largely refractory to anticoagulation and/or antiplatelet therapy ...
[und viele weitere], Mannes, Marco, Schmidt, Christoph Q.   +2 more
core   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Complement regulatory proteins in glomerular diseases [PDF]

, 1998
Complement regulatory proteins in glomerular diseases. Complement activation plays a critical role in the pathogenesis of many forms of glomerulonephritis.
Nangaku, Masaomi
core   +1 more source

HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis [PDF]

, 2017
Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.
Borjabad, Alejandra, Chao, Wei, Emdad, Luni, Fisher, Paul B., Morgello, Susan, Murray, Jacinta, Nitkiewicz, Jadwiga, Potash, Mary Jane, Volsky, David J.   +8 more
core   +2 more sources

Pathways of complement activation in glomerulonephritis [PDF]

Kidney International, 1972
Pathways of complement activation in glomerulonephritis.Systemic lupus erythematosus and hypocomplementemic glomerulonephritis are characterized by depressed CH50 and C3 levels, but the complement profiles in these two diseases show marked differences.Measurement of hemolytic activity of C1, C4 and C2 and of protein concentrations by radial ...
Maria M.E. de Bracco, Charles L. Christian, Nancy H. Holland   +2 more
openaire   +2 more sources