Results 41 to 50 of about 638,552 (336)
Structural insights on complement activation [PDF]
The FEBS Journal, 2015 The proteolytic cleavage of C3 to generate C3b is the central and most important step in the activation of complement, a major component of innate immunity. The comparison of the crystal structures of C3 and C3b illustrates large conformational changes during the transition from C3 to C3b.
Alcorlo, Martín +7 more
openaire +4 more sources
Early complementopathy predicts the outcomes of patients with trauma
Trauma Surgery & Acute Care Open, 2019 Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu +6 more
doaj +1 more source
Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
BMC Immunology, 2021 Background The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. Results 217 patients with renal biopsy-proven active LN were enrolled.
Fengmei Wang +6 more
doaj +1 more source
Precision Nanomedicine, 2018 Complement activation can be evaluated in vitro using plasma or serum from animals and human donors, and in vivo using animal models. Despite many years of research, there is no harmonized approach for the selection of matrix and animal models. Herein,
Barry W Neun +3 more
doaj +1 more source
Complement Activation and Inhibition in Wound Healing
Clinical and Developmental Immunology, 2012 Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore,
Gwendolyn Cazander +2 more
doaj +1 more source
Frontiers in Immunology, 2016 While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and release of proinflammatory factors C3a and C5a may
Guankui Wang +6 more
doaj +1 more source
Impact of intrinsic localized modes of atomic motion on materials properties [PDF]
, 2010 Recent neutron and x-ray scattering measurements show intrinsic localized modes (ILMs) in metallic uranium and ionic sodium iodide. Here, the role ILMs play in the behavior of these materials is examined.
Manley, M. E.
core +2 more sources
FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]
, 2017 Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia +7 more
core +1 more source
Terminal complement activation is increased and associated with disease severity in CIDP [PDF]
, 2016 Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic autoimmune neuropathy. While both cell-mediated and humoral mechanisms contribute to its pathogenesis, the rapid clinical response to plasmapheresis implicates a ...
Hiepe, Falk +4 more
core +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source