Results 41 to 50 of about 4,342,004 (341)
Frontiers in Immunology, 2018 Background: Bullous pemphigoid is a subepidermal blistering skin disease, associated with autoantibodies to hemidesmosomal proteins, complement activation at the dermal-epidermal junction, and dermal granulocyte infiltration.
Roxana M. Chiorean +9 more
doaj +1 more source
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
mBio, 2018 The complement system is a critical part of host defense to many bacterial, viral, and fungal infections. It works alongside pattern recognition receptors to stimulate host defense systems in advance of activation of the adaptive immune response. In this
Lisa E. Gralinski +8 more
semanticscholar +1 more source
Early complementopathy predicts the outcomes of patients with trauma
Trauma Surgery & Acute Care Open, 2019 Background Complementopathy (rapid complement activation and consumption after trauma) has been reported in trauma patients, but the underlying mechanism of these phenomena and their clinical significance remain unclear. This study aimed to determine the
Bin Liu +6 more
doaj +1 more source
Platelet Mediated Complement Activation [PDF]
, 2008 The complement system comprises a series of proteases and inhibitors that are activated in cascade-like fashion during host defense (Makrides 1998). A growing body of evidence supports the hypothesis that immune mechanisms, including complement activation, are involved in inflammatory conditions associated with vascular injury (Acostan et al.
Ellinor I B, Peerschke +2 more
openaire +2 more sources
Precision Nanomedicine, 2018 Complement activation can be evaluated in vitro using plasma or serum from animals and human donors, and in vivo using animal models. Despite many years of research, there is no harmonized approach for the selection of matrix and animal models. Herein,
Barry W Neun +3 more
doaj +1 more source
Modern view on the complement system role in membranous nephropathy
Терапевтический архив, 2022 Membranous nephropathy (MN), an immune-mediated glomerular disease, is the most common cause of adult nephrotic syndrome. In MN, proteinuria is developed by podocyte damage due to the complement system activation in response to the subepithelial ...
Elena S. Kamyshova +2 more
doaj +1 more source
ACS Nano, 2019 Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild-to-severe hypersensitivity reactions (HSRs) which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier to the use of these drugs, yet
G. Kozma +11 more
semanticscholar +1 more source
Complement Activation and Inhibition in Wound Healing
Clinical and Developmental Immunology, 2012 Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore,
Gwendolyn Cazander +2 more
doaj +1 more source
Frontiers in Immunology, 2016 While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and release of proinflammatory factors C3a and C5a may
Guankui Wang +6 more
doaj +1 more source
Nanoporesize affects complement activation
Journal of Biomedical Materials Research Part A, 2008 AbstractIn the present study, we have shown the vast importance of biomaterial nanotexture when evaluating inflammatory response. For the first time in an in vitro whole blood system, we have proven that a small increase in nanoporesize, specifically 180 nm (from 20 to 200 nm), has a huge effect on the complement system.
Ferraz, Natalia +3 more
openaire +4 more sources