Results 31 to 40 of about 40,238 (270)

Different Complement Activation Pathways Underly Cognitive Impairment and Type 2 Diabetes Mellitus Combined With Cognitive Impairment

Frontiers in Aging Neuroscience, 2022
BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li, Weiwei Zhang, Feng Gao, Feng Gao, Qiqiang Tang, Dongmei Kang, Yong Shen, Yong Shen   +7 more
doaj   +1 more source

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Frontiers in Immunology, 2019
Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
Isabelle Bally, Antonio Inforzato, Antonio Inforzato, Fabien Dalonneau, Matteo Stravalaci, Matteo Stravalaci, Barbara Bottazzi, Christine Gaboriaud, Nicole M. Thielens   +8 more
doaj   +1 more source

Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor [PDF]

, 2016
Copyright: © 2016 Kaur, Sultan, Murugaiah, Pathan, Alhamlan, Karteris and Kishore. Human C1q is the first recognition subcomponent of the complement classical pathway that plays a vital role in the clearance of immune complexes, pathogens and apoptotic ...
Alhamlan, F, Karteris, E, Kaur, A, Kishore, U, Murugaiah, V, Pathan, AA, Sultan, SHA   +6 more
core   +1 more source

Role of collectins and complement protein C1q in pregnancy and parturition [PDF]

Immunobiology, 2016
Collectins such as surfactant proteins SP-A, SP-D, and mannan-binding lectin (MBL), as well as complement protein C1q are evolutionarily conserved innate immune molecules. They are known to opsonize a range of microbial pathogens (bacteria, fungi, virus, and parasites) and trigger effector clearance mechanisms involving phagocytosis and/or complement ...
Shanmuga Priyaa Madhukaran, Fatimah S. Alhamlan, Kavita Kale, Manu Vatish, Taruna Madan, Uday Kishore   +5 more
openaire   +5 more sources

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

Frontiers in Immunology, 2017
Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
doaj   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble, Brodsky-Doyle, Chen, Chen, Christopher Furze, Daniel A. Mitchell, Doliana, Emsley, Fan, Feinberg, Girija, Haurum, Heise, Hohenester, Hoppe, Jensenius, Julia Toth, Kaufman, Kurata, Phillips, Porter, Reid, Reid, Reid, Russell Wallis, Scherer, Shoulders, Sim, Strang, Teillet, Uemura, Umakhanth Venkatraman Girija, Wallis, Wallis, Wallis, Wallis, Wallis, Wallis, Wilhelm J. Schwaeble   +38 more
core   +2 more sources

Glomerular C1q deposition and serum anti-C1q antibodies in anti-glomerular basement membrane disease [PDF]

, 2013
BACKGROUND: Anti-glomerular basement membrane (GBM) disease is a well-known antibody-induced autoimmune disease. A few patients have glomerular C1q deposition, but it is usually absent on renal histopathology.
Feng Yu, Ming-hui Zhao, Shui-yi Hu, Xiao-wei Yang, Xiao-yu Jia, Zhao Cui   +5 more
core   +1 more source

Complement C1q expression in Erythema nodosum leprosum

PLOS Neglected Tropical Diseases, 2018
Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction.
Edessa Negera, Edessa Negera, Tsehaynesh Lema, Abraham Aseffa, Stephen L. Walker, Diana N. J. Lockwood, Hazel M. Dockrell   +6 more
openaire   +4 more sources

C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina

Frontiers in Neural Circuits, 2020
During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is ...
Courtney A. Burger, Courtney A. Burger, Danye Jiang, Danye Jiang, Fenge Li, Fenge Li, Melanie A. Samuel, Melanie A. Samuel   +7 more
doaj   +1 more source