Results 31 to 40 of about 23,738 (171)

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques

Frontiers in Immunology, 2017
Inflammation is a part of the initial process leading to atherosclerosis and cholesterol crystals (CC), found in atherosclerotic plaques, which are known to induce complement activation.
Katrine Pilely, Stefano Fumagalli, Anne Rosbjerg, Ninette Genster, Mikkel-Ole Skjoedt, Carlo Perego, Angela M. R. Ferrante, Maria-Grazia De Simoni, Peter Garred   +8 more
doaj   +1 more source

Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy

Frontiers in Immunology, 2017
As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood ...
Limei Zhao, Limei Zhao, Shuai Shao, Shuai Shao, Yi Chen, Yi Chen, Ximeng Sun, Ximeng Sun, Ran Sun, Jingjing Huang, Jingjing Huang, Bin Zhan, Xinping Zhu, Xinping Zhu   +13 more
doaj   +1 more source

C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina

Frontiers in Neural Circuits, 2020
During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is ...
Courtney A. Burger, Courtney A. Burger, Danye Jiang, Danye Jiang, Fenge Li, Fenge Li, Melanie A. Samuel, Melanie A. Samuel   +7 more
doaj   +1 more source

Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein

Viruses, 2023
The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag, Praveen M. Varghese, Martin Mayora Neto, Ahmad Al Aiyan, Haseeb A. Khan, Moneeb Qablan, Mohamed H. Shamji, Robert B. Sim, Nigel Temperton, Uday Kishore   +9 more
doaj   +1 more source

Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

Frontiers in Immunology, 2018
IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal, Johann Rahmöller, Johann Rahmöller, Janina Petry, Yannic C. Bartsch, Alexei Leliavski, Marc Ehlers, Marc Ehlers   +7 more
doaj   +1 more source

MafB is a critical regulator of complement component C1q [PDF]

Nature Communications, 2017
AbstractThe transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced inMafb-deficient macrophages.
Mai Thi Nhu Tran, Michito Hamada, Hyojung Jeon, Risako Shiraishi, Keigo Asano, Motochika Hattori, Megumi Nakamura, Yuki Imamura, Yuki Tsunakawa, Risa Fujii, Toshiaki Usui, Kaushalya Kulathunga, Christina-Sylvia Andrea, Ryusuke Koshida, Risa Kamei, Yurina Matsunaga, Makoto Kobayashi, Hisashi Oishi, Takashi Kudo, Satoru Takahashi   +19 more
openaire   +3 more sources

Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]

PLoS ONE, 2018
INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee, Eunhee Han, Ae-Ran Choi, Tae Hyun Ban, Byung Ha Chung, Chul Woo Yang, Yeong Jin Choi, Eun-Jee Oh   +7 more
doaj   +1 more source

Interaction Studies of Hexameric and Pentameric IgMs with Serum-Derived C1q and Recombinant C1q Mimetics

Life
The interaction between IgM and C1q represents the first step of the classical pathway of the complement system in higher vertebrates. To identify the significance of particular IgM/C1q interactions, recombinant IgMs were used in both hexameric and ...
Maria Magdalena John, Monika Hunjadi, Vanessa Hawlin, Jean-Baptiste Reiser, Renate Kunert   +4 more
doaj   +1 more source

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Cell Reports, 2019
Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. Mentis   +7 more
doaj   +1 more source

Emerging Roles of Complement Protein C1q in Neurodegeneration [PDF]

Aging and disease, 2019
The innate immune system is an ancient and primary component system that rapidly reacts to defend the body against external pathogens. C1 is the initial responder of classical pathway of the innate immune system. C1 is comprised of C1q, C1r, and C1s.
openaire   +2 more sources