Results 31 to 40 of about 41,476 (260)
Engineering novel complement activity into a pulmonary surfactant protein [PDF]
, 2010 Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble +38 more
core +2 more sources
Frontiers in Immunology, 2019 Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
Isabelle Bally +8 more
doaj +1 more source
Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor [PDF]
, 2016 Copyright: © 2016 Kaur, Sultan, Murugaiah, Pathan, Alhamlan, Karteris and Kishore. Human C1q is the first recognition subcomponent of the complement classical pathway that plays a vital role in the clearance of immune complexes, pathogens and apoptotic ...
Alhamlan, F +6 more
core +1 more source
Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
core +1 more source
Role of collectins and complement protein C1q in pregnancy and parturition [PDF]
Immunobiology, 2016 Collectins such as surfactant proteins SP-A, SP-D, and mannan-binding lectin (MBL), as well as complement protein C1q are evolutionarily conserved innate immune molecules. They are known to opsonize a range of microbial pathogens (bacteria, fungi, virus, and parasites) and trigger effector clearance mechanisms involving phagocytosis and/or complement ...
Shanmuga Priyaa Madhukaran +5 more
openaire +5 more sources
TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement [PDF]
, 2014 Immune molecules, including complement proteins C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement localizes to synapses and refines the developing visual system via C3-dependent microglial phagocytosis of ...
Bialas, Allison R., Stevens, Beth
core +1 more source
C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
doaj +1 more source
Is serum complement C1q related to major depressive disorder? [PDF]
Indian J Psychiatry, 2020 Major depressive disorder (MDD) has a high global incidence. While the pathogenesis of depression remains unknown, accumulating evidence has implicated inflammatory changes.The aim of the study is to compare the serum complement C1q levels in patients with MDD and healthy controls.The design was a case-control study.Blood samples were collected from ...
Yang J, Li R, Shi Y, Jiang S, Liu J.
europepmc +4 more sources
Complement activation and protein adsorption by carbon nanotubes [PDF]
, 2006 As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel +5 more
core +2 more sources
C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina
Frontiers in Neural Circuits, 2020 During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is ...
Courtney A. Burger +7 more
doaj +1 more source