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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
doaj +8 more sources
Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3 [PDF]
MicrobiomeBackground Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression,
Wenzhi Hao +8 more
doaj +3 more sources
Cell Reports, 2019 Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focused on ...
Tiffany Wu +21 more
doaj +2 more sources
C3‐dependent effector functions of complement
Immunological Reviews, 2022 C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments
A. Zarantonello +3 more
semanticscholar +3 more sources
The versatile functions of complement C3‐derived ligands [PDF]
Immunological Reviews, 2016 SummaryThe complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self‐structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated.
A. Erdei +5 more
semanticscholar +6 more sources
Association of serum complement C3 level with disease severity in primary pterygium [PDF]
Frontiers in MedicinePurposeTo investigate whether various systemic inflammatory and immunologic markers—including complement C3, C4, antinuclear antibodies (ANA), rheumatoid factor (RF), and other autoantibodies—are associated with the clinical severity of primary nasal ...
Young In Yun +3 more
doaj +2 more sources
Complement C3 Polymorphism In Greenland Eskimos [PDF]
Thrombosis and Haemostasis, 1981 The C3F gene has been associated with atherosclerotic vascular disease. Greenland Eskimos have a very low frequency of acute myocardial infarction (AMI). The C3 polymorphism phenotypes were therefore determined by high-voltage agarose gel electrophoresis in 125 Greenland Eskimos originating from different parts of Greenland and compared with a control ...
K A Jørqensen +3 more
openalex +2 more sources
The complement C3 protein family in invertebrates [PDF]
Invertebrate Survival Journal, 2011 Complement C3 plays a pivotal role in the innate immune system of mammals as the central component of the complement system essential for its activation mechanism and effecter function.
M Nonaka
doaj +2 more sources
BMJ Open, 2021 Objectives Recently studies demonstrated that adipose tissue can produce and release complement C3 and serum complement C3 levels were associated with diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Wei-Lin Wang, Ying Zhao, Limin Feng
doaj +1 more source
Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors
Journal of Innate Immunity, 2023 Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use.
Jin Chen +6 more
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