Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes [PDF]
Journal of Hematology & Oncology, 2017 Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica +5 more
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Serum complement C3 as a diagnostic biomarker for metabolic dysfunction -associated steatotic liver disease in middle-aged and elderly adults: a cross-sectional study [PDF]
BMC GastroenterologyBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, with significant liver fibrosis (SLF) determining clinical outcomes.
Dan Ye +7 more
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The Significance of Newly Derived Disease Activity Parameters Neutrophil/Albumin Ratio, Neutrophil/Complement C3 Ratio, and Albumin/Globulin Ratio in a Group of Patients With Lupus Nephritis. [PDF]
CureusRabrenovic V +5 more
europepmc +3 more sources
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Barthel, Diana +7 more
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BMJ Open, 2021 Objectives Recently studies demonstrated that adipose tissue can produce and release complement C3 and serum complement C3 levels were associated with diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Wei-Lin Wang, Ying Zhao, Limin Feng
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Complement C3 in panvascular disease: a central integrator of immune signaling and vascular remodeling. [PDF]
Clin Sci (Lond)Li Y, Zeng H, Zhong X.
europepmc +2 more sources
Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors
Journal of Innate Immunity, 2023 Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use.
Jin Chen +6 more
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Sanamed, 2022 Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
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A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]
PeerJ, 2019 Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki +8 more
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Frontiers in Genetics, 2021 Schizophrenia is a common neuropsychiatric disorder with complex pathophysiology. Recent reports suggested that complement system alterations contributed to pathological synapse elimination that was associated with psychiatric symptoms in schizophrenia ...
Yu Chen +11 more
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