Results 1 to 10 of about 976,767 (186)

Complement C3 recognition by C3 convertases. [PDF]

Sci Adv
Abstract The complement system plays a fundamental role in human immunity, and its dysregulation is implicated in numerous diseases. Activation of the complement occurs through three main pathways: classical, lectin, and alternative; which converge at the central component, C3.
Jia C, Yang X, Zhao MH, Tan Y, Xiao J.
europepmc   +3 more sources

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Cell Reports, 2019
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focused on ...
Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson   +21 more
doaj   +2 more sources

Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

Microbiome
Background Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression,
Wenzhi Hao, Qingyu Ma, Lu Wang, Naijun Yuan, Hua Gan, Liangliang He, Xiaojuan Li, Junqing Huang, Jiaxu Chen   +8 more
doaj   +2 more sources

C3‐dependent effector functions of complement

Immunological Reviews, 2022
SummaryC3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites.
Alessandra Zarantonello, Margot Revel, Anne Grunenwald, Lubka T. Roumenina   +3 more
openaire   +3 more sources

The versatile functions of complement C3‐derived ligands [PDF]

Immunological Reviews, 2016
SummaryThe complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self‐structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated.
Erdei, Anna, Sándor, Noémi, Mácsik-Valent, Bernadett, Lukácsi, Szilvia Zsófia, Kremlitzka, Mariann, Bajtay, Zsuzsanna   +5 more
openaire   +5 more sources

Serum complement C3 as a diagnostic biomarker for metabolic dysfunction -associated steatotic liver disease in middle-aged and elderly adults: a cross-sectional study [PDF]

BMC Gastroenterology
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, with significant liver fibrosis (SLF) determining clinical outcomes.
Dan Ye, Haifen Ma, Jingjing Zhou, Jiaofeng Wang, Jiaheng Shi, Jie Chen, Zhijun Bao, Xiaona Hu   +7 more
doaj   +2 more sources

Complement C3 Measurement [PDF]

Definitions, 2020
openaire   +2 more sources

Association between complement C3 and the prevalence of metabolic-associated fatty liver disease in a Chinese population: a cross-sectional study

BMJ Open, 2021
Objectives Recently studies demonstrated that adipose tissue can produce and release complement C3 and serum complement C3 levels were associated with diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Wei-Lin Wang, Ying Zhao, Limin Feng
doaj   +1 more source

Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors

Journal of Innate Immunity, 2023
Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use.
Jin Chen, Lingjun Zhang, Maojing Yang, Elizabeth D. Hughes, Zachary T. Freeman, Thomas L. Saunders, Feng Lin   +6 more
doaj   +1 more source

SERUM C3 AND SERUM C4 COMPLEMENT IN PATIENTS WITH BURN TRAUMA AND CORRELATION WITH BURN INJURY SEVERITY

Sanamed, 2022
Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
doaj   +1 more source