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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
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Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3 [PDF]
MicrobiomeBackground Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression,
Wenzhi Hao +8 more
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Complement C3 Polymorphism In Greenland Eskimos [PDF]
Thrombosis and Haemostasis, 1981 The C3F gene has been associated with atherosclerotic vascular disease. Greenland Eskimos have a very low frequency of acute myocardial infarction (AMI). The C3 polymorphism phenotypes were therefore determined by high-voltage agarose gel electrophoresis in 125 Greenland Eskimos originating from different parts of Greenland and compared with a control ...
K A Jørqensen +3 more
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The complement C3 protein family in invertebrates [PDF]
Invertebrate Survival Journal, 2011 Complement C3 plays a pivotal role in the innate immune system of mammals as the central component of the complement system essential for its activation mechanism and effecter function.
M Nonaka
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BMJ Open, 2021 Objectives Recently studies demonstrated that adipose tissue can produce and release complement C3 and serum complement C3 levels were associated with diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Wei-Lin Wang, Ying Zhao, Limin Feng
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Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors
Journal of Innate Immunity, 2023 Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use.
Jin Chen +6 more
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Sanamed, 2022 Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
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Alternative C3 Complement System: Lipids and Atherosclerosis [PDF]
International Journal of Molecular Sciences, 2021 Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque ...
Maisa Garcia-Arguinzonis +7 more
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A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]
PeerJ, 2019 Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki +8 more
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Immunological Reviews, 2022 SummaryC3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites.
Alessandra Zarantonello +3 more
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