Results 11 to 20 of about 862,879 (325)

Complement C3 inhibition in severe COVID-19 using compstatin AMY-101

Science Advances, 2022
Complement C3 activation contributes to COVID-19 pathology, and C3 targeting has emerged as a promising therapeutic strategy. We provide interim data from ITHACA, the first randomized trial evaluating a C3 inhibitor, AMY-101, in severe COVID-19 (PaO2 ...
P. Skendros, G. Germanidis, D. Mastellos, C. Antoniadou, E. Gavriilidis, Georgios Kalopitas, Anna Samakidou, Angelos Liontos, A. Chrysanthopoulou, Maria Ntinopoulou, D. Kogias, Ioanna Karanika, A. Smyrlis, Dainora Cepaityte, Iliana Fotiadou, Nikoleta Zioga, I. Mitroulis, N. Gatselis, C. Papagoras, S. Metallidis, H. Milionis, G. Dalekos, L. Willems, B. Persson, V. Manivel, B. Nilsson, E. Connolly, S. Iacobelli, V. Papadopoulos, R. Calado, M. Huber-Lang, A. Risitano, Despina Yancopoulou, K. Ritis, John D Lambris   +34 more
semanticscholar   +1 more source

Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity

Frontiers in Immunology, 2022
In the complement system, C3 is a central component in complement activation, immune defense and immune regulation. In all pathways of complement activation, the pivotal step is conversion of the component C3 to C3b and C3a, which is responsible to ...
Meng Wu, Bei-bei Jia, Mo-fei Li
semanticscholar   +1 more source

SERUM C3 AND SERUM C4 COMPLEMENT IN PATIENTS WITH BURN TRAUMA AND CORRELATION WITH BURN INJURY SEVERITY

Sanamed, 2022
Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
doaj   +1 more source

Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3

Nature Communications, 2021
Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic stage possess potent metastasis-promoting activity. RNA-seq reveals
Zhiyuan Zheng, Ya-nan Li, Shanfen Jia, Mengting Zhu, L. Cao, M. Tao, Jingting Jiang, S. Zhan, Yongjing Chen, Ping Gao, Weiguo Hu, Ying Wang, C. Shao, Yufang Shi   +13 more
semanticscholar   +1 more source

Alternative C3 Complement System: Lipids and Atherosclerosis [PDF]

International Journal of Molecular Sciences, 2021
Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque ...
Maisa Garcia-Arguinzonis, Elisa Diaz-Riera, Esther Peña, Rafael Escate, Oriol Juan-Babot, Pedro Mata, Lina Badimon, Teresa Padro   +7 more
openaire   +4 more sources

Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression

Frontiers in Immunology, 2021
Activation of the complement system has been observed in coronavirus disease 19 (COVID-19). We conducted a systematic review and meta-analysis with meta-regression to investigate possible differences in the serum concentrations of two routinely measured ...
A. Zinellu, A. Mangoni
semanticscholar   +1 more source

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]

PeerJ, 2019
Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki, Peter Pichler, Karl Mechtler, Richard Imre, Ines Steinmacher, Gürkan Sengölge, Daniela Knafl, Georg Beilhack, Ludwig Wagner   +8 more
doaj   +2 more sources

Associations Between Genotype and Peripheral Complement Proteins in First-Episode Psychosis: Evidences From C3 and C4

Frontiers in Genetics, 2021
Schizophrenia is a common neuropsychiatric disorder with complex pathophysiology. Recent reports suggested that complement system alterations contributed to pathological synapse elimination that was associated with psychiatric symptoms in schizophrenia ...
Yu Chen, Yu Chen, Zhenguo Zhao, Zhenguo Zhao, Fen Lin, Fen Lin, Lifang Wang, Lifang Wang, Zheng Lin, Weihua Yue, Weihua Yue, Weihua Yue   +11 more
doaj   +1 more source

Increased Serum Complement C3 Levels Are Associated With Adverse Clinical Outcomes After Ischemic Stroke.

Stroke, 2021
BACKGROUND AND PURPOSE Complement C3 has been implicated in inflammation and ischemia/reperfusion injury, but its impact on the prognosis of ischemic stroke remains unclear. Aim of this study was to prospectively investigate the association between serum
Pinni Yang, Zhengbao Zhu, Y. Zang, X. Bu, Tian Xu, C. Zhong, Aili Wang, Hao Peng, D. Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He   +13 more
semanticscholar   +1 more source

Microarray-based analysis of renal complement components reveals a therapeutic target for lupus nephritis

Arthritis Research & Therapy, 2021
Background Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN.
Tao Liu, Mingyue Yang, Ying Xia, Chuan Jiang, Chenxu Li, Zhenyu Jiang, Xiaosong Wang   +6 more
doaj   +1 more source