Results 11 to 20 of about 97,543 (311)
A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]
PeerJ, 2019 Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki +8 more
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Frontiers in Genetics, 2021 Schizophrenia is a common neuropsychiatric disorder with complex pathophysiology. Recent reports suggested that complement system alterations contributed to pathological synapse elimination that was associated with psychiatric symptoms in schizophrenia ...
Yu Chen +11 more
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Arthritis Research & Therapy, 2021 Background Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN.
Tao Liu +6 more
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Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
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Therapeutic Advances in Chronic Disease, 2020 Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid ...
Iván Arias de la Rosa +17 more
doaj +1 more source
Analysis of C3 suggests three periods of positive selection events and different evolutionary patterns between fish and mammals. [PDF]
PLoS ONE, 2012 BACKGROUND: The third complement component (C3) is a central protein of the complement system conserved from fish to mammals. It also showed distinct characteristics in different animal groups.
Fanxing Meng +5 more
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Circulating Complement Levels and C3 Glomerulopathy [PDF]
Clinical Journal of the American Society of Nephrology, 2014 The complement system is an essential part of innate immunity acting as a first-line defense against infection and provides an interface between innate and adaptive immunity ([1][1],[2][2]). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase).
Sanjeev Sethi, Fernando C. Fervenza
openaire +3 more sources
Recurrent pyogenic infections caused by a novel Gln1420* mutation in the C3 gene
Frontiers in Pediatrics, 2022 C3 is a crucial protein of the complement system. Congenital C3 deficiency is extremely rare and manifests through recurrent, severe infections and should always be considered as a differential diagnosis of recurrent pyogenic infections. We report a case
Pedro Simão Coelho +8 more
doaj +1 more source
Immunological Reviews, 2022 SummaryC3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites.
Alessandra Zarantonello +3 more
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Systemic complement activation levels in Stargardt disease.
PLoS ONE, 2021 PurposePreclinical research provides evidence for the complement system as a potential common pathway in Stargardt disease (STGD1) and age-related macular degeneration (AMD) leading to retinal pigment epithelium (RPE) loss.
Patty P A Dhooge +6 more
doaj +1 more source