Results 11 to 20 of about 268,987 (334)

The versatile functions of complement C3-derived ligands [PDF]

Immunological Reviews, 2016
The complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self-structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several ...
Ahearn, Altieri, Andrews, Arvieux, Aubry, Baiu, Bajtay, Bajtay, Barro, Baudino, Bellinger-Kawahara, Berger, Beyer, Bohnsack, Bretscher, Cabec, Cardone, Carroll, Carroll, Carroll, Carter, Carter, Castro, Chen, Chen, Colten, Corbi, Cravedi, Daha, Dempsey, Diamond, Ehirchiou, Erdei, Erdei, Erdei, Erdei, Erdei, Ezekowitz, Fearon, Fingeroth, Flick, Frade, Gadjeva, Georgakopoulos, Ghannam, Ghebrehiwet, Gros, Gupta, Han, Heeger, Helmy, Holers, Hynes, Iida, Illges, Ingalls, Isaak, Jacobson, Jozsi, Karnchanaphanurach, Kemper, Kerekes, Kerekes, Kerekov, Klos, Kooten, Kremlitzka, Kuraya, Kurtz, Law, Law, Li, Li, Liddington, Lu, Luxembourg, Maison, Marquart, Marquart, Matsumoto, Melchers, Miller, Miller, Mitchell, Mold, Molina, Morelli, Mueller-Ortiz, Nelson, Nemerow, Nicolaou, Nielsen, Ogembo, Olesen, Oliva, Pantazis, Papp, Patel, Pepys, Peyron, Pliyev, Postigo, Praz, Prechl, Prechl, Prieto, Prodeus, Puentes, Ramos, Raposo, Reis, Renzo, Ross, Rubtsov, Sacks, Sandor, Sandor, Schlesinger, Schmidt, Sim, Sim, Singh-Jasuja, Sissons, Skoberne, Sohn, Strainic, Strijp, Tan, Tedder, Thacker, Torok, Torok, Touw, Tsokos, Tsokos, Tsokos, Tuveson, Ueda, Ugarova, Verbovetski, Villiers, Wagner, Watry, Wehr, Weiss, White, Wilson, Wright, Yan, Zaffran, Zhang, Zhou, Zhou   +152 more
core   +6 more sources

C3‐dependent effector functions of complement

Immunological Reviews, 2022
SummaryC3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites.
Alessandra Zarantonello, Margot Revel, Anne Grunenwald, Lubka T. Roumenina   +3 more
openaire   +2 more sources

Microarray-based analysis of renal complement components reveals a therapeutic target for lupus nephritis

Arthritis Research & Therapy, 2021
Background Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN.
Tao Liu, Mingyue Yang, Ying Xia, Chuan Jiang, Chenxu Li, Zhenyu Jiang, Xiaosong Wang   +6 more
doaj   +1 more source

Alternative C3 Complement System: Lipids and Atherosclerosis [PDF]

International Journal of Molecular Sciences, 2021
Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque ...
Maisa Garcia-Arguinzonis, Elisa Diaz-Riera, Esther Peña, Rafael Escate, Oriol Juan-Babot, Pedro Mata, Lina Badimon, Teresa Padro   +7 more
openaire   +3 more sources

Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
doaj   +1 more source

Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis

Therapeutic Advances in Chronic Disease, 2020
Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid ...
Iván Arias de la Rosa, Pilar Font, Alejandro Escudero-Contreras, María Dolores López-Montilla, Carlos Pérez-Sánchez, María Carmen Ábalos-Aguilera, Lourdes Ladehesa-Pineda, Alejandro Ibáñez-Costa, Carmen Torres-Granados, Yolanda Jimenez-Gomez, Alejandra Patiño-Trives, María Luque-Tévar, María Carmen Castro-Villegas, Jerusalem Calvo-Gutiérrez, Rafaela Ortega-Castro, Chary López-Pedrera, Eduardo Collantes-Estévez, Nuria Barbarroja   +17 more
doaj   +1 more source

Analysis of C3 suggests three periods of positive selection events and different evolutionary patterns between fish and mammals. [PDF]

PLoS ONE, 2012
BACKGROUND: The third complement component (C3) is a central protein of the complement system conserved from fish to mammals. It also showed distinct characteristics in different animal groups.
Fanxing Meng, Yuena Sun, Xuezhu Liu, Jianxin Wang, Tianjun Xu, Rixin Wang   +5 more
doaj   +1 more source

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P, Barlow, Paul N, Cook, H. T, Cooke, Katie, Denton, Harriet, Kavanagh, David, Liszewski, M. K, Marchbank, Kevin J, Pappworth, Isabel Y, Pickering, Matthew C, Smith-Jackson, Kate, Yang, Yi   +11 more
core   +3 more sources

Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice

Eye and Vision, 2022
Background It has been found that the extensive use of anticancer drugs containing DNA-alkylating agents not only target cancer cells but also cause retinal inflammation through toxic intermediates.
Lu Du, Guang-Hua Peng
doaj   +1 more source

A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]

, 2017
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto, Bu, Hrishikesh S. Kulkarni, John P. Atkinson, Liszewski, M. Kathryn Liszewski, Michelle Elvington, Nickells, Paula Bertram, Seya, Singer, Vĕtvicka   +11 more
core   +2 more sources