Results 21 to 30 of about 976,787 (206)

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

Clinical Immunology, 2020
Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-19 pneumonia and is mainly based on an immune-driven pathology.
S. Mastaglio, Annalisa Ruggeri, A. Risitano, P. Angelillo, Despina Yancopoulou, D. Mastellos, Markus S. Huber-Lang, S. Piemontese, A. Assanelli, Cecilia Garlanda, John D Lambris, F. Ciceri   +11 more
semanticscholar   +1 more source

Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
doaj   +1 more source

Increased Serum Complement C3 Levels Are Associated With Adverse Clinical Outcomes After Ischemic Stroke.

Stroke, 2021
BACKGROUND AND PURPOSE Complement C3 has been implicated in inflammation and ischemia/reperfusion injury, but its impact on the prognosis of ischemic stroke remains unclear. Aim of this study was to prospectively investigate the association between serum
Pinni Yang, Zhengbao Zhu, Y. Zang, X. Bu, Tian Xu, C. Zhong, Aili Wang, Hao Peng, D. Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He   +13 more
semanticscholar   +1 more source

Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis

Therapeutic Advances in Chronic Disease, 2020
Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid ...
Iván Arias de la Rosa, Pilar Font, Alejandro Escudero-Contreras, María Dolores López-Montilla, Carlos Pérez-Sánchez, María Carmen Ábalos-Aguilera, Lourdes Ladehesa-Pineda, Alejandro Ibáñez-Costa, Carmen Torres-Granados, Yolanda Jimenez-Gomez, Alejandra Patiño-Trives, María Luque-Tévar, María Carmen Castro-Villegas, Jerusalem Calvo-Gutiérrez, Rafaela Ortega-Castro, Chary López-Pedrera, Eduardo Collantes-Estévez, Nuria Barbarroja   +17 more
doaj   +1 more source

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion

Theranostics, 2020
Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement C3-C3aR pathway after chronic ...
Lin-Yuan Zhang, Jia-ji Pan, Muyassar Mamtilahun, Yuan Zhu, Liping Wang, Ashwin Venkatesh, Rubing Shi, Xuan-qiang Tu, K. Jin, Yongting Wang, Zhi-jun Zhang, Guo-Yuan Yang   +11 more
semanticscholar   +1 more source

Analysis of C3 suggests three periods of positive selection events and different evolutionary patterns between fish and mammals. [PDF]

PLoS ONE, 2012
BACKGROUND: The third complement component (C3) is a central protein of the complement system conserved from fish to mammals. It also showed distinct characteristics in different animal groups.
Fanxing Meng, Yuena Sun, Xuezhu Liu, Jianxin Wang, Tianjun Xu, Rixin Wang   +5 more
doaj   +1 more source

Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice

Eye and Vision, 2022
Background It has been found that the extensive use of anticancer drugs containing DNA-alkylating agents not only target cancer cells but also cause retinal inflammation through toxic intermediates.
Lu Du, Guang-Hua Peng
doaj   +1 more source

The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus

Glia, 2020
Gliosis is a histopathological characteristic of epilepsy that comprises activated microglia and astrocytes. It is unclear whether or how crosstalk occurs between microglia and astrocytes in the evolution of epilepsy.
Yujia Wei, Tingjun Chen, D. Bosco, Manling Xie, Jiaying Zheng, Aastha Dheer, Yanlu Ying, Qian Wu, V. Lennon, Long-Jun Wu   +9 more
semanticscholar   +1 more source

Circulating Complement Levels and C3 Glomerulopathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
The complement system is an essential part of innate immunity acting as a first-line defense against infection and provides an interface between innate and adaptive immunity ([1][1],[2][2]). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase).
Fernando C, Fervenza, Sanjeev, Sethi
openaire   +2 more sources

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H

Frontiers in Immunology, 2020
Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig, Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Lars Fester, Moin A. Saleem, Jun Oh, Jun Oh   +14 more
doaj   +1 more source