Results 21 to 30 of about 862,879 (325)
Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion
Theranostics, 2020 Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement C3-C3aR pathway after chronic ...
Lin-Yuan Zhang +11 more
semanticscholar +1 more source
Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
doaj +1 more source
The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus
Glia, 2020 Gliosis is a histopathological characteristic of epilepsy that comprises activated microglia and astrocytes. It is unclear whether or how crosstalk occurs between microglia and astrocytes in the evolution of epilepsy.
Yujia Wei +9 more
semanticscholar +1 more source
Therapeutic Advances in Chronic Disease, 2020 Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid ...
Iván Arias de la Rosa +17 more
doaj +1 more source
Analysis of C3 suggests three periods of positive selection events and different evolutionary patterns between fish and mammals. [PDF]
PLoS ONE, 2012 BACKGROUND: The third complement component (C3) is a central protein of the complement system conserved from fish to mammals. It also showed distinct characteristics in different animal groups.
Fanxing Meng +5 more
doaj +1 more source
Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice
Eye and Vision, 2022 Background It has been found that the extensive use of anticancer drugs containing DNA-alkylating agents not only target cancer cells but also cause retinal inflammation through toxic intermediates.
Lu Du, Guang-Hua Peng
doaj +1 more source
Journal of experimental & clinical cancer research : CR, 2020 Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related ...
Kaitao Yuan +7 more
semanticscholar +1 more source
Circulating Complement Levels and C3 Glomerulopathy [PDF]
Clinical Journal of the American Society of Nephrology, 2014 The complement system is an essential part of innate immunity acting as a first-line defense against infection and provides an interface between innate and adaptive immunity ([1][1],[2][2]). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase).
Sanjeev Sethi, Fernando C. Fervenza
openaire +3 more sources
Complement C3 and allergic asthma: a cohort study of the general population
European Respiratory Journal, 2020 Complement C3 plays a role in asthma development and severity. We tested the hypothesis that high plasma complement C3 concentration is associated with high risks of asthma hospitalisation and exacerbation.
S. Vedel-Krogh +3 more
semanticscholar +1 more source
Systemic complement activation levels in Stargardt disease.
PLoS ONE, 2021 PurposePreclinical research provides evidence for the complement system as a potential common pathway in Stargardt disease (STGD1) and age-related macular degeneration (AMD) leading to retinal pigment epithelium (RPE) loss.
Patty P A Dhooge +6 more
doaj +1 more source