Results 21 to 30 of about 74,672 (291)
Systemic complement activation levels in Stargardt disease.
PLoS ONE, 2021 PurposePreclinical research provides evidence for the complement system as a potential common pathway in Stargardt disease (STGD1) and age-related macular degeneration (AMD) leading to retinal pigment epithelium (RPE) loss.
Patty P A Dhooge +6 more
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Conformational Complexity of Complement Component C3
, 2007 The structures of native C3 and its major fragment C3c have provided a wealth of structural insights into the central protein of the complement system. The proteolytic activation steps, generating the important fragments C3b and iC3b, are thought to induce significant conformational changes in the molecule, yielding protein molecules with distinct ...
Janssen, B.J.C., Gros, P.
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Assessment of the Role of C3(H2O) in the Alternative Pathway
Frontiers in Immunology, 2020 In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system.
Karin Fromell +9 more
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Frontiers in Immunology, 2021 The zoonotic intracellular bacterium Chlamydia psittaci causes life-threatening pneumonia in humans. During mouse lung infection, complement factor C3 and the anaphylatoxin C3a augment protection against C. psittaci by a so far unknown mechanism.
Martin Kohn +5 more
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Association of the porcine
Genetics Selection Evolution, 2003 The complement component C3 plays an essential role in the activated complement system, which is involved in phagocytosis, inflammation and immunoregulation to destroy infectious microorganisms.
Mekchay Supamit +3 more
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Role of complement C3 in diabetic nephropathy
Linchuang shenzangbing zazhi, 2022 As one of the most common microvascular complications of diabetes， diabetic kidney disease （DKD） is one of the major causes of end-stage renal disease. Complement system participates in both innate and adaptive immunities of human body. Three pathways of
Wang Qing-qing +3 more
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Complement content in plasma under different storage conditions
Zhongguo shuxue zazhi, 2023 Objective To investigate the changes in complement content in component blood before blood transfusion. Methods 180 samples from 20 plasma donors were collected at different stages of the preparation process, stored at different temperatures and time ...
Zhi HAN, Yujie HAN, Haihong ZHANG
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Defining the Complement Biomarker Profile of C3 Glomerulopathy [PDF]
Clinical Journal of the American Society of Nephrology, 2014 C3 glomerulopathy (C3G) applies to a group of renal diseases defined by a specific renal biopsy finding: a dominant pattern of C3 fragment deposition on immunofluorescence. The primary pathogenic mechanism involves abnormal control of the alternative complement pathway, although a full description of the disease spectrum remains to be determined.
Zhang, Yuzhou +8 more
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Structural insights into the central complement component C3 [PDF]
Molecular Immunology, 2007 C3 is a central protein of the complement system, which is important to immune defense and provides a link between innate and adaptive immunity. Three pathways of complement activation converge at the activation of C3 yielding a diverse set of biological responses.
Janssen, B.J.C., Gros, P.
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Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting
Scientific Reports, 2017 Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang +10 more
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