Results 31 to 40 of about 74,672 (291)

Comparative characteristics of the complement system in patients with C3-glomerulopathy and atypical hemolytic uremic syndrome of chronic course who suffered an acute episode of thrombotic microangiopathy

Терапевтический архив, 2023
Aim. To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy. Materials and methods.
Valeriya A. Yurova, Natalia L. Kozlovskaya, Larisa A. Bobrova, Leonid V. Kozlov, Svetlana S. Andina, Kseniya A. Demyanova   +5 more
doaj   +1 more source

The versatile functions of complement C3‐derived ligands [PDF]

Immunological Reviews, 2016
SummaryThe complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self‐structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated.
Erdei, Anna, Sándor, Noémi, Mácsik-Valent, Bernadett, Lukácsi, Szilvia Zsófia, Kremlitzka, Mariann, Bajtay, Zsuzsanna   +5 more
openaire   +5 more sources

Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies

Pediatric Rheumatology Online Journal, 2020
Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly, Kristen Hayward, Matthew L. Basiaga, Eric J. Allenspach   +3 more
doaj   +1 more source

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes

Journal of Hematology & Oncology, 2017
Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica, Tommaso Rondelli, Patrizia Ricci, Maria De Angioletti, Antonio M. Risitano, Rosario Notaro   +5 more
doaj   +1 more source

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Frontiers in Immunology, 2020
Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang, Chi Zhang, Shihui Fu, Minghao Zhao, Deping Liu, Deping Liu, Yali Zhao, Yao Yao, Yao Yao   +8 more
doaj   +1 more source

C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]

Childhood Kidney Diseases
Complement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim, Jae Il Shin, Ji Hong Kim, Jiyoung Oh, Ji-Man Kang, Hee Gyung Kang, Seong Heon Kim, Byoung Soo Cho, Keum Hwa Lee   +8 more
doaj   +1 more source

Complement C3 and Nonalcoholic Fatty Liver Disease in Chronic Kidney Disease Patients: A Pilot Study

Kidney & Blood Pressure Research, 2020
Context: Evidences have suggested complement C3 is a biomarker for nonalcoholic fatty liver disease (NAFLD) in the general population. Objective: The present study was conducted to explore the predictive function of C3 for NAFLD in chronic kidney disease
Binbin Pan, Xin Wan, Mengqing Ma, Changchun Cao   +3 more
doaj   +1 more source

A Novel Homozygous In-Frame Deletion in Complement Factor 3 Underlies Early-Onset Autosomal Recessive Atypical Hemolytic Uremic Syndrome - Case Report

Frontiers in Immunology, 2021
Background and ObjectivesAtypical hemolytic uremic syndrome (aHUS) is mostly attributed to dysregulation of the alternative complement pathway (ACP) secondary to disease-causing variants in complement components or regulatory proteins.
Shirley Pollack, Shirley Pollack, Israel Eisenstein, Adi Mory, Tamar Paperna, Ayala Ofir, Hagit Baris-Feldman, Karin Weiss, Nóra Veszeli, Dorottya Csuka, Revital Shemer, Fabian Glaser, Zoltán Prohászka, Daniella Magen, Daniella Magen   +14 more
doaj   +1 more source

Platelet-bound complement (C3) in immune thrombocytopenia [PDF]

Blood, 1977
The fixation of complement to the circulating platelet in immune thrombocytopenia was detected by measurement of one of the complement components, C3, on the surface of platelets from patients with idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) using the anti-C3 consumption assay.
Thomas W. Hauch, Wendell F. Rosse
openaire   +4 more sources

Complement C3 and C5 deficiency affects fracture healing. [PDF]

PLoS ONE, 2013
There is increasing evidence that complement may play a role in bone development. Our previous studies demonstrated that the key complement receptor C5aR was strongly expressed in the fracture callus not only by immune cells but also by bone cells and ...
Christian Ehrnthaller, Markus Huber-Lang, Per Nilsson, Ronny Bindl, Simon Redeker, Stefan Recknagel, Anna Rapp, Tom Mollnes, Michael Amling, Florian Gebhard, Anita Ignatius   +10 more
doaj   +1 more source