Results 31 to 40 of about 976,787 (206)

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

medRxiv, 2020
Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel thrombotic microangiopathy and NET-driven immunothrombosis, thereby exacerbating cytokine-driven hyper ...
D. Mastellos, Bruno G. P. Pires da Silva, B. A. Fonseca, Natasha P. Fonseca, M. Auxiliadora-Martins, S. Mastaglio, A. Ruggeri, M. Sironi, P. Radermacher, A. Chrysanthopoulou, P. Skendros, K. Ritis, Ilenia Manfra, S. Iacobelli, Markus Huber-Lang, B. Nilsson, Despina Yancopoulou, E. Connolly, C. Garlanda, F. Ciceri, A. Risitano, R. Calado, John D Lambris   +22 more
semanticscholar   +1 more source

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.

Immunity, 2020
Intrinsic complement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell responses. Increased or decreased intracellular C3 results in autoimmunity and infections, respectively.
M. Kolev, E. West, Natalia Kunz, D. Chauss, E. Moseman, J. Rahman, T. Freiwald, M. L. Balmer, J. Lötscher, Sarah Dimeloe, Sarah Dimeloe, Elizabeth C. Rosser, Elizabeth C. Rosser, Lucy R. Wedderburn, Lucy R. Wedderburn, Lucy R. Wedderburn, K. Mayer-Barber, Andrea C. Bohrer, P. Lavender, A. Cope, Luopin Wang, M. Kaplan, N. Moutsopoulos, D. McGavern, S. Holland, Christoph Hess, Christoph Hess, M. Kazemian, B. Afzali, C. Kemper, C. Kemper, C. Kemper   +31 more
semanticscholar   +1 more source

Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression

Journal of experimental & clinical cancer research : CR, 2020
Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related ...
Kaitao Yuan, Jinning Ye, Zhenguo Liu, Yufeng Ren, Wei-ling He, Jianbo Xu, Yulong He, Yujie Yuan   +7 more
semanticscholar   +1 more source

Correlation between serum level of complement C3 and abdominal aortic calcification in maintenance hemodialysis patients

Linchuang shenzangbing zazhi, 2021
Objective To explore the correlation between serum level of complement C3 and abdominal aortic calcification（AAC）in maintenance hemodialysis（MHD）patients.Methods A total of 127 MHD patients hospitalized between February 2019 and December 2019 were ...
Zhao Xin, Bi Chun-sheng
doaj  

Linking Complement C3 and B Cells in Nasal Polyposis

Journal of Immunology Research, 2020
Nasal polyposis often is characterized by a persistent inflammation of the sinonasal mucosa, disease recurrence after medical or surgical intervention, and asthma comorbidity.
Ulrike Werner, Axel Künstner, Maren Drenckhan, Ralph Pries, Karl-Ludwig Bruchhage, Hauke S. Busch, Claus Bachert, Barbara Wollenberg   +7 more
doaj   +1 more source

Systemic complement activation levels in Stargardt disease.

PLoS ONE, 2021
PurposePreclinical research provides evidence for the complement system as a potential common pathway in Stargardt disease (STGD1) and age-related macular degeneration (AMD) leading to retinal pigment epithelium (RPE) loss.
Patty P A Dhooge, Esmee H Runhart, Catherina H Z Li, Corrie M de Kat Angelino, Carel B Hoyng, Renate G van der Molen, Anneke I den Hollander   +6 more
doaj   +1 more source

Recurrent pyogenic infections caused by a novel Gln1420* mutation in the C3 gene

Frontiers in Pediatrics, 2022
C3 is a crucial protein of the complement system. Congenital C3 deficiency is extremely rare and manifests through recurrent, severe infections and should always be considered as a differential diagnosis of recurrent pyogenic infections. We report a case
Pedro Simão Coelho, Catarina Gouveia, Catarina Gouveia, Marta Valente Pinto, Conceição Neves, Ana Isabel Cordeiro, João Farela Neves, João Farela Neves, João Farela Neves   +8 more
doaj   +1 more source

Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: A retrospective cohort study

International Immunopharmacology, 2020
Highlights • The IgA and IgE levels increased significantly, while C3 level decreased in non-survivors.• Decreased complement C3 level was correlated with increased odds of death.• Low level of C3 may be an alert to the attending that patients may be of ...
Shilin Fang, Haizhou Wang, Linjuan Lu, Yifan Jia, Z. Xia   +4 more
semanticscholar   +1 more source

Role of complement C3 in diabetic nephropathy

Linchuang shenzangbing zazhi, 2022
As one of the most common microvascular complications of diabetes， diabetic kidney disease （DKD） is one of the major causes of end-stage renal disease. Complement system participates in both innate and adaptive immunities of human body. Three pathways of
Wang Qing-qing, Wang Yue, Li Yan-bo, Sun Wei-xia   +3 more
doaj  

Association of the porcine C3 gene with haemolytic complement activity in the pig

Genetics Selection Evolution, 2003
The complement component C3 plays an essential role in the activated complement system, which is involved in phagocytosis, inflammation and immunoregulation to destroy infectious microorganisms.
Mekchay Supamit, Ponsuksili Siriluck, Schellander Karl, Wimmers Klaus   +3 more
doaj   +1 more source