Results 31 to 40 of about 97,543 (311)
Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting
Scientific Reports, 2017 Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang +10 more
doaj +1 more source
Терапевтический архив, 2023 Aim. To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy. Materials and methods.
Valeriya A. Yurova +5 more
doaj +1 more source
Structural insights into the central complement component C3 [PDF]
Molecular Immunology, 2007 C3 is a central protein of the complement system, which is important to immune defense and provides a link between innate and adaptive immunity. Three pathways of complement activation converge at the activation of C3 yielding a diverse set of biological responses.
Janssen, B.J.C., Gros, P.
openaire +5 more sources
CR regular embeddings and immersions of compact orientable 4-manifolds into C3 [PDF]
Internat. J. Math. 26 (2015), no. 5, 2015 We show that a compact orientable 4-manifold M has a CR regular immersion into C3 if and only if both its first Pontryagin class and its Euler characteristic vanish, and has a CR regular embedding into C3 if and only if in addition the second Stiefel-Whitney class of M vanishes.
arxiv +1 more source
The versatile functions of complement C3‐derived ligands [PDF]
Immunological Reviews, 2016 SummaryThe complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self‐structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated.
Erdei, Anna +5 more
openaire +5 more sources
Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies
Pediatric Rheumatology Online Journal, 2020 Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly +3 more
doaj +1 more source
On C3-Like Finsler Metrics Under Ricci Flow [PDF]
arXiv, 2021 In this paper we have studied the class of Finsler metrics, called C3-like metrics which satisfy the un-normal and normal Ricci flow equation and proved that such metrics are Einstein.
arxiv
Unified representation of the C3, C4, and CAM photosynthetic pathways with the Photo3 model [PDF]
Ecological Modelling, 384, 173-187 (2018), 2018 Recently, interest in crassulacean acid metabolism (CAM) photosynthesis has risen and new, physiologically based CAM models have emerged. These models show promise, yet unlike the more widely used physiological models of C3 and C4 photosynthesis, their complexity has thus far inhibited their adoption in the general community.
arxiv +1 more source
Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022 Benzoxazolinate is a rare bis‐heterocyclic moiety that interacts with proteins and DNA. It was found that a putative acyl AMP‐ligase mediates the last cyclization step to afford benzoxazolinate. The enzyme was then used as a probe for genome mining, which led to the discovery of a new class of benzoxazolinate‐containing compounds in diverse bacteria ...
Yi‐Ming Shi +12 more
wiley +2 more sources
Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes
Journal of Hematology & Oncology, 2017 Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica +5 more
doaj +1 more source