Results 111 to 120 of about 49,845 (259)

C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.

PLoS ONE, 2014
ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li, Qinghua Yin, Xi Tang, Lin Bai, Jie Zhang, Shenju Gou, Hongping Zhu, Jingqiu Cheng, Ping Fu, Fang Liu   +9 more
doaj   +1 more source

Serious Neurologic Adverse Events in Tofersen Clinical Trials for Amyotrophic Lateral Sclerosis

Muscle &Nerve, Volume 71, Issue 6, Page 1006-1015, June 2025.
ABSTRACT Introduction/Aims Tofersen is approved for the treatment of amyotrophic lateral sclerosis (ALS) due to superoxide dismutase 1 mutations (SOD1‐ALS). Here we report serious neurologic adverse events (AEs) that occurred in the tofersen clinical trials in people with SOD1‐ALS.
Alexandra Lovett, Sowmya Chary, Suma Babu, Gaëlle Bruneteau, Jonathan D. Glass, Merete Karlsborg, Shafeeq Ladha, Keith Mayl, Christopher McDermott, Robert C. Bucelli, Adriano Chiò, Toby A. Ferguson, Thos Cochrane, Stephanie Fradette, Karen Smirnakis, Jennifer Inra, Sohail Malek, Laura Fanning   +17 more
wiley   +1 more source

Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
doaj   +1 more source

Complement, C1q, and C1q-related molecules regulate macrophage polarization

Frontiers in Immunology, 2014
Complement is a critical system of enzymes, regulatory proteins and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions ...
Suzanne Slater Bohlson, Sean David O'Conner, Holly J Hulsebus, Minh-Minh eHo, Deborah Ann Fraser   +4 more
doaj   +1 more source

Overwintering Does Not Affect Microbiota Diversity in Halyomorpha halys: Implications for Its Ecology and Management

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
We challenged the assumption that overwintering significantly alters host microbiota composition, finding no differences between Halyomorpha halys populations sampled before and after overwintering. This microbiota stability underscores its role in the invasive pest's resilience and provides insights for ecological management strategies.
Riccardo Piccinno, Giulio Galla, Gerardo Roselli, Mirco Rodeghiero, Valerio Mazzoni, Lloyd Stringer, Heidi Christine Hauffe, Gianfranco Anfora, Omar Rota‐Stabelli   +8 more
wiley   +1 more source

Huntington's disease: An immune perspective [PDF]

, 2011
Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Ansar, R, Bonifati, DM, Kishore, U, Nayak, A, Verma, SK   +4 more
core   +3 more sources

Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response

Journal of Neuroinflammation
Background Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others ...
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
doaj   +1 more source

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Journal of Translational Medicine, 2019
Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth, Werner Dammermann   +4 more
doaj   +1 more source

Ficolin‐3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
FCN3‐mediated activation of the lectin complement pathway via MASP2 binding induces necroptosis in cholangiocarcinoma cells through the RIPK1/RIPK3/MLKL axis. ABSTRACT Ficolin 3 (FCN3) is a pattern recognition molecule that activates the complement system via the lectin pathway.
Zeyu Zhang, Maopeng Yin, Xueyan Geng, Hongxi Zhao, Shoucai Zhang, Yingjie Liu, Yongyuan Liang, Jian Ji, Guixi Zheng   +8 more
wiley   +1 more source

Every Hilbert space frame has a Naimark complement [PDF]

arXiv, 2011
Naimark complements for Hilbert space Parseval frames are one of the most fundamental and useful results in the field of frame theory. We will show that actually all Hilbert space frames have Naimark complements which possess all the usual properties for Naimark complements with one notable exception.
arxiv