Results 121 to 130 of about 27,207 (241)

Implementation Punctuation: The Role of Feedback, Narratives, and Implementation in the Punctuated Equilibrium Theory

Policy Studies Journal, EarlyView.
ABSTRACT Based on the Punctuated Equilibrium Theory (PET) and implementation research, this study proposes an extended conceptualization of policy punctuation that enables researchers to systematically include policy implementation as part of a punctuation. The key mechanisms underlying the PET, i.e., policy image and venue, information processing, and
Bettina Stauffer
wiley   +1 more source

Aging at Criticality in Model C Dynamics [PDF]

, 2002
We study the off-equilibrium two-point critical response and correlation functions for the relaxational dynamics with a coupling to a conserved density (Model C) of the O(N) vector model.
A. Chakrabarti, A. Gambassi, A. Pelissetto, A. Picone, A. Picone, A.J. Bray, B. Zheng, C. Godrèche, C. Godrèche, C. Godrèche, D. Stauffer, E. Brézin, E. Lippiello, E. Vincent, G. Besold, H. Tanaka, H.K. Janssen, J. Kockelkoren, K. Binder, K. Oerding, K.R. Elder, L. Caiani, L. Caiani, L.F. Cugliandolo, L.F. Cugliandolo, L.F. Cugliandolo, M. Henkel, M. Henkel, M. San Miguel, P. Calabrese, P. Calabrese, P. Calabrese, P. Calabrese, P. Calabrese, P. Sen, P.C. Hohenberg, R. Bausch, R. Folk, R. Folk, T. Ohta, V.I. Gorentsveig   +40 more
core   +3 more sources

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response

Journal of Neuroinflammation
Background Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others ...
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
doaj   +1 more source

Complement, C1q, and C1q-related molecules regulate macrophage polarization

Frontiers in Immunology, 2014
Complement is a critical system of enzymes, regulatory proteins and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions ...
Suzanne Slater Bohlson, Sean David O'Conner, Holly J Hulsebus, Minh-Minh eHo, Deborah Ann Fraser   +4 more
doaj   +1 more source

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin

EBioMedicine, 2016
Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems.
Jonathan H. Foley, Bethany L. Walton, Maria M. Aleman, Alice M. O'Byrne, Victor Lei, Micaela Harrasser, Kimberley A. Foley, Alisa S. Wolberg, Edward M. Conway   +8 more
doaj   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

PLoS Pathogens, 2017
The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays a vital role in opsonization of bacteria
Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan   +6 more
doaj   +1 more source

Beyond bacterial defences: the role of lysozyme in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang, Qian Dong, Fuchu He, Zhiwen Gu, Aihua Sun   +4 more
wiley   +1 more source