Results 31 to 40 of about 13,347 (154)

Anaphylatoxin C3a receptors in asthma

Respiratory Research, 2005
The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
Panettieri Reynold A, Ali Hydar
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Astrocyte Responses to Complement Peptide C3a are Highly Context-Dependent

Neurochemical Research, 2022
AbstractAstrocytes perform a range of homeostatic and regulatory tasks that are critical for normal functioning of the central nervous system. In response to an injury or disease, astrocytes undergo a pronounced transformation into a reactive state that involves changes in the expression of many genes and dramatically changes astrocyte morphology and ...
Pekna, Marcela, Siqin, Sumen, de Pablo, Yolanda, Stokowska, Anna, Naluai, Åsa Torinsson, Pekny, Milos   +5 more
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The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]

PLoS ONE, 2013
Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A Wetsel, Silke Glage, Andreas Klos   +6 more
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Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia [PDF]

Brain, 2016
Ischaemic stroke induces endogenous repair processes that include proliferation and differentiation of neural stem cells and extensive rewiring of the remaining neural connections, yet about 50% of stroke survivors live with severe long-term disability.
Stokowska, Anna, Atkins, Alison L, Morán, Javier, Pekny, Tulen, Bulmer, Linda, Pascoe, Michaela, Barnum, Scott R, Wetsel, Rick A, Nilsson, Jonas A, Dragunow, Mike, Pekna, Marcela   +10 more
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Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
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C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

Journal of Innate Immunity, 2021
To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with ...
Susanne Mommert, Lisa Doenni, Phillip Szudybill, Christoph Zoeller, Frerk Hinnerk Beyer, Thomas Werfel   +5 more
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Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration

Ophthalmology Science, 2022
Purpose: To investigate the association of risk alleles in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with complement activation products in the aqueous humor in eyes with neovascular age-related macular degeneration ...
Yutaka Kato, MD, Yasuharu Oguchi, MD, PhD, Tomoko Omori, PhD, Akihito Kasai, MD, Masashi Ogasawara, MD, Yukinori Sugano, MD, PhD, Kanako Itagaki, MD, Akira Ojima, MD, PhD, Yumi Ishida, Takeshi Machida, PhD, Hideharu Sekine, MD, PhD, Tetsuju Sekiryu, MD, PhD   +11 more
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Elevated complement C3a in plasma from patients with severe acute asthma [PDF]

Journal of Allergy and Clinical Immunology, 2003
Complement component C3a, an anaphylatoxin, provokes acute inflammatory responses, including smooth muscle contraction, mucus hypersecretion, increase in vascular permeability, and recruitment of inflammatory cells. Thus C3a may be related to airway inflammation and bronchoconstriction in acute asthma exacerbation.We sought to determine whether plasma ...
Yutaka, Nakano, Satoru, Morita, Akira, Kawamoto, Takahumi, Suda, Kingo, Chida, Hirotoshi, Nakamura   +5 more
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Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Journal of Neuroinflammation, 2010
Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C, Simovic Milomir, Dalle Lucca Shawn L, Li Yansong, Wang Ying, Dalle Lucca Jurandir J   +5 more
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Biomarkers of the Complement System Activation (C3a, C5a, sC5b-9) in Serum of Patients before and after Liver Transplantation

Biomedicines, 2023
The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today.
Marta Budkowska, Ewa Ostrycharz, Natalia Maria Serwin, Łukasz Nazarewski, Elżbieta Cecerska-Heryć, Marta Poręcka, Paweł Rykowski, Radosław Pietrzak, Krzysztof Zieniewicz, Aldona Siennicka, Beata Hukowska-Szematowicz, Barbara Dołęgowska   +11 more
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