Results 31 to 40 of about 27,207 (241)
Scientific Reports, 2021 We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka +13 more
doaj +1 more source
Drusen complement components C3a and C5a promote choroidal neovascularization [PDF]
Proceedings of the National Academy of Sciences, 2006 Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark of AMD is the presence of drusen, extracellular deposits that accumulate beneath the retinal pigmented epithelium.
Miho, Nozaki +10 more
openaire +2 more sources
Nociceptive sensitization by complement C5a and C3a in mouse [PDF]
Pain, 2010 Activation of the complement system by injury increases inflammation by producing complement fragments C5a and C3a which are able to recruit and activate immune cells. Complement activation may contribute to pain after inflammation and injury. In this study, we examined whether C5a and C3a elicit nociception when injected into mouse hind paws in vivo ...
Jun Ho, Jang +5 more
openaire +2 more sources
Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor [PDF]
Bioconjugate Chemistry, 2017 Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime.
Aline Dantas de Araujo +6 more
openaire +3 more sources
Complement protein C3a enhances adaptive immune responses towards FVIII products
Haematologica, 2023 The most serious complication in the treatment of hemophilia A (HA) is the development of factor (F)VIII inhibitors or antidrug antibodies (ADA) occurring in 25-35% of patients with severe HA. The immunological mechanisms underlying the development of ADA against FVIII products have not been completely understood yet.
Eva Ringler +6 more
openaire +3 more sources
Complement C3a Regulates Late Asthmatic Response and Airway Hyperresponsiveness in Mice [PDF]
The Journal of Immunology, 2009 Abstract Allergic asthma is a chronic inflammatory disorder of the airways characterized by biphasic airway obstruction and airway hyperresponsiveness. In this study, we attempted to elucidate the contribution of the complement C3a to these asthmatic symptoms. BALB/c mice sensitized by i.p.
Nobuaki Mizutani +2 more
openalex +4 more sources
Reduced order modeling and analysis of the human complement system. [PDF]
PLoS ONE, 2017 Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation.
Adithya Sagar +4 more
doaj +1 more source
Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity [PDF]
Frontiers in Immunology, 2022 In the complement system, C3 is a central component in complement activation, immune defense and immune regulation. In all pathways of complement activation, the pivotal step is conversion of the component C3 to C3b and C3a, which is responsible to eliminate the pathogen and opsonization.
Meng Wu +7 more
openaire +3 more sources
Role of Complement Activation in Obliterative Bronchiolitis Post Lung Transplantation [PDF]
, 2013 Obliterative bronchiolitis (OB) post lung transplantation involves IL-17 regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation.
Benson, Heather L. +21 more
core +2 more sources
Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]
Scandinavian Journal of Immunology, 2008 AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
R B, Stricker +3 more
openaire +2 more sources