Results 41 to 50 of about 13,347 (154)

Characterization of Synthetic C3a Analog Peptides on Human Eosinophils in Comparison to the Native Complement Component C3a [PDF]

The Journal of Immunology, 2000
Abstract The C3a anaphylatoxin is a potent proinflammatory mediator derived from the complement system inducing biologic effects of human eosinophils like Ca2+ transients and the activation of the respiratory burst. These findings support an important role for C3a in diseases typically associated with a peripheral blood or tissue ...
H, Petering, J, Köhl, A, Weyergraf, Y, Dulkys, D, Kimmig, R, Smolarski, A, Kapp, J, Elsner   +7 more
openaire   +2 more sources

Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury [PDF]

Kidney International, 2011
To prevent injury to host tissues, complement activation is regulated by a number of plasma and membrane-associated proteins, most of which limit C3 and C5 activation. An influx of circulating C3 from a syngeneic host into donor kidneys deficient in Crry (a membrane protein that reduces C3 convertase activity) causes spontaneous complement activation ...
Bao, Lihua, Wang, Ying, Haas, Mark, Quigg, Richard J.   +3 more
openaire   +2 more sources

Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. [PDF]

PLoS ONE, 2017
The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood.
Xue-Jun Zhao, Timothy M Larkin, Molly A Lauver, Saif Ahmad, Andrew F Ducruet   +4 more
doaj   +1 more source

Induction of Complement C3a Receptor Responses by Kallikrein-Related Peptidase 14 [PDF]

The Journal of Immunology, 2013
Abstract Activation of the complement system is primarily initiated by pathogen- and damage-associated molecular patterns on cellular surfaces. However, there is increasing evidence for direct activation of individual complement components by extrinsic proteinases as part of an intricate crosstalk between physiological effector systems ...
Katerina, Oikonomopoulou, Robert A, DeAngelis, Hui, Chen, Eleftherios P, Diamandis, Morley D, Hollenberg, Daniel, Ricklin, John D, Lambris   +6 more
openaire   +2 more sources

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist

Frontiers in Pharmacology, 2021
Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities ...
Xaria X. Li, Vinod Kumar, Richard J. Clark, John D. Lee, Trent M. Woodruff   +4 more
doaj   +1 more source

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention. [PDF]

PLoS ONE, 2018
The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism has been ...
Nehemiah Zewde, Dimitrios Morikis
doaj   +1 more source

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

Bothrops jararaca Snake Venom Inflammation Induced in Human Whole Blood: Role of the Complement System

Frontiers in Immunology, 2022
The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulopathy,
Thyago Bispo Leonel, Joel José Megale Gabrili, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, John D. Lambris, Denise V. Tambourgi   +5 more
doaj   +1 more source

Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration [PDF]

Developmental Cell, 2011
Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the
Carmona-Fontaine, Carlos, Theveneau, Eric, Tzekou, Apostolia, Tada, Masazumi, Woods, Mae, Page, Karen M., Parsons, Madeline, Lambris, John D., Mayor, Roberto   +8 more
openaire   +3 more sources

Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy?

Biology
Emerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins, Valeria Molina, Stanley Wiernicki, Kenneth Okwuegbe, Xiaodong Feng, Hongbin Wang   +5 more
doaj   +1 more source