Symmetries and hidden symmetries of $(ε, d_L)$-twisted knot complements [PDF]
Algebr. Geom. Topol. 22 (2022) 601-656, 2019 In this paper we analyze symmetries, hidden symmetries, and commensurability classes of $(\epsilon, d_L)$-twisted knot complements, which are the complements of knots that have a sufficiently large number of twists in each of their twist regions. These knot complements can be constructed via long Dehn fillings on fully augmented links complements.
arxiv +1 more source
Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]
, 2020 Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia +8 more
core +2 more sources
Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]
, 2011 BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A +5 more
core +2 more sources
Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. [PDF]
PLoS ONE, 2017 The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood.
Xue-Jun Zhao +4 more
doaj +1 more source
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core +1 more source
Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]
, 1993 Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin +8 more
core +1 more source
Denaturation and unfolding of human anaphylatoxin C3a: an unusually low covalent stability of its native disulfide bonds. [PDF]
, 2008 The complement C3a anaphylatoxin is a major molecular mediator of innate immunity. It is a potent activator of mast cells, basophils and eosinophils and causes smooth muscle contraction.
Chang, Jui-Yoa +4 more
core +1 more source
The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist
Frontiers in Pharmacology, 2021 Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities ...
Xaria X. Li +4 more
doaj +1 more source
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
European Journal of Pharmacology, 2014 The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury. Complement C3a and C5a are key mediators produced by this cascade, and their dysregulation has been linked to a plethora of inflammatory and autoimmune diseases.
Halai, R. +10 more
openaire +3 more sources
Price Discovery and Efficiency in Uniswap Liquidity Pools
Journal of Futures Markets, EarlyView.ABSTRACT Using almost three years of minute‐level data, we show that the efficiency of Uniswap v3 is much improved relative to v2, and some v3 pools are approaching or even exceeding Bitstamp in terms of price discovery ability. Regression results suggest that the channels of influence for these improvements are an increase in informed liquidity ...
Carol Alexander +3 more
wiley +1 more source