Results 61 to 70 of about 13,347 (154)

Enzymatic Reactions and Detection of C3 Cleavage Fragments

Bio-Protocol, 2014
The complement component C3 is the major effector molecule of the complement system. C3 circulates in the blood and interstitial fluids as pro-enzyme and is activated by enzymatic cleavage into a C3a portion, a classic anaphylatoxin that functions as ...
Claudia Kemper, Martin Kolev
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Clinical significance of circulating immune complexes and components of the blood complement system in viral meningitis in children

Лечащий Врач
Background. Neuroinfections are one of the global medical and social problems of pediatrics, due to the high incidence of neurological complications that affect the further development of the child.Objective. To establish the clinical significance of the
G. A. Kharchenko, O. G. Kimirilova
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Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
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C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.

PLoS ONE, 2014
ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li, Qinghua Yin, Xi Tang, Lin Bai, Jie Zhang, Shenju Gou, Hongping Zhu, Jingqiu Cheng, Ping Fu, Fang Liu   +9 more
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Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin

EBioMedicine, 2016
Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems.
Jonathan H. Foley, Bethany L. Walton, Maria M. Aleman, Alice M. O'Byrne, Victor Lei, Micaela Harrasser, Kimberley A. Foley, Alisa S. Wolberg, Edward M. Conway   +8 more
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Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response

Journal of Neuroinflammation
Background Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others ...
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
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Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

PLoS Pathogens, 2017
The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays a vital role in opsonization of bacteria
Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan   +6 more
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Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Journal of Translational Medicine, 2019
Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth, Werner Dammermann   +4 more
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Mice lacking acylation stimulating protein (ASP) have delayed postprandial triglyceride clearance

Journal of Lipid Research, 1999
Acylation stimulating protein (ASP) is a 76 amino acid fragment of the third component of complement (C3) which is generated by the interaction of adipsin and factor B with C3.
I. Murray, A.D. Sniderman, K. Cianflone
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Complement, C1q, and C1q-related molecules regulate macrophage polarization

Frontiers in Immunology, 2014
Complement is a critical system of enzymes, regulatory proteins and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions ...
Suzanne Slater Bohlson, Sean David O'Conner, Holly J Hulsebus, Minh-Minh eHo, Deborah Ann Fraser   +4 more
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