Results 71 to 80 of about 49,845 (259)
Modulation of human lymphocyte function by C3a and C3a(70-77). [PDF]
, 1982 Human C3a and the synthetic octapeptide C3a (70-77), which retains the activities of an anaphylatoxin, inhibit in a concentration-dependent manner the generation of leukocyte inhibitory factor (LIF) activity by human mononuclear leukocytes and T ...
Goetzl, EJ, Payan, DG, Trentham, DE
core
The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention. [PDF]
PLoS ONE, 2018 The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism has been ...
Nehemiah Zewde, Dimitrios Morikis
doaj +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
Frontiers in Immunology, 2020 Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner +14 more
doaj +1 more source
Frontiers in Immunology, 2022 The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulopathy,
Thyago Bispo Leonel +5 more
doaj +1 more source
Observation on Reaction Mechanism of Lime Powder as Desulfurization Agent for Molten Cast Iron
steel research international, EarlyView.The reaction layer between lime particles and molten cast iron is comprehensively analyzed as one of the key factors in sustaining the lime‐based desulfurization process. The findings indicate the involvement of silicon, aluminum, iron, oxygen, and sulfur in a complex interplay forming specific slag systems and precipitations regulated by their ...
Ida Adhiwiguna +3 more
wiley +1 more source
Small Structures, EarlyView.Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han +11 more
wiley +1 more source
Early Elevations of the Complement Activation Fragment C3a and Adverse Pregnancy Outcomes [PDF]
Obstetrics & Gynecology, 2011 To estimate whether elevations of complement C3a early in pregnancy are predictive of the subsequent development of adverse pregnancy outcomes.A plasma sample was obtained from each enrolled pregnant woman before 20 weeks of gestation. The cohort (n=1,002) was evaluated for the development of adverse pregnancy outcomes defined as hypertensive diseases ...
Jane E. Salmon +5 more
openaire +3 more sources