Complement C4, Infections, and Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang +3 more
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High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage [PDF]
Frontiers in Aging Neuroscience, 2023 ObjectiveThe complement cascade is activated and contributes to the brain injury after intracerebral hemorrhage (ICH). Complement component 4 (C4), an important component of complement cascade, has been associated with severity of neurological impairment
Moxin Wu +10 more
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Evaluation of serum complement C4 among COVID-19 patients in Khartoum state: a case control-based study [version 1; peer review: 2 approved] [PDF]
F1000Research, 2023 Background: The complement system is made up of an abundance of unique plasma proteins that play an important role in innate immunity and inflammation, aiding in the fight against pathogenic microbes and viral diseases.
Babbiker Mohammed Taher Gorish +3 more
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Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson’s disease [PDF]
npj Parkinson's DiseaseComplement C4, implicated in neuroinflammation and synaptic dysfunction, plays a poorly defined role in Parkinson’s disease (PD). Here, we demonstrate elevated C4 levels in PD patient plasma and the substantia nigra of α-synuclein preformed fibril (α-syn
Wenkai Zou +6 more
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Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder [PDF]
Neuropsychiatric Disease and Treatment, 2021 Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of ...
Pan C +7 more
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Levels of complement C3 and C4 components in Amerindians living in an area with high prevalence of tuberculosis [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 The levels of complement C3 and C4 components were determined in non-indigenous (creoles) and indigenous (Warao) populations, the latter with an extremely high tuberculosis (TB) rate.
Zaida Araujo +9 more
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A complement C4–derived glycopeptide is a biomarker for PMM2-CDG [PDF]
JCI InsightBACKGROUNDDiagnosis of PMM2-CDG, the most common congenital disorder of glycosylation (CDG), relies on measuring carbohydrate-deficient transferrin (CDT) and genetic testing. CDT tests have false negatives and may normalize with age. Site-specific changes in protein N-glycosylation have not been reported in sera in PMM2-CDG.METHODSUsing multistep mass ...
Kishore Garapati +22 more
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Effect of olanzapine on changes in serum complement factors levels in patients with first-episode schizophrenia [PDF]
BMC PsychiatryObjective An increasing number of studies have demonstrated that patients with schizophrenia (SCZ) exhibit complement system disorders, and alterations in serum complement factor levels may serve as biomarkers for guiding the diagnosis, prognosis, and ...
Yin Cao +5 more
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Complement C4, C4A and C4a – What they do and how they differ [PDF]
Brain, Behavior, & Immunity - HealthMeike Heurich +2 more
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Journal of Marine Science and Engineering, 2023 In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah +4 more
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