Results 1 to 10 of about 25,871 (73)

Complement C4, Infections, and Autoimmune Diseases

Frontiers in Immunology, 2021
Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang, Hongbin Wang, Hongbin Wang, Mengyao Liu   +3 more
doaj   +1 more source

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage

Frontiers in Aging Neuroscience, 2023
ObjectiveThe complement cascade is activated and contributes to the brain injury after intracerebral hemorrhage (ICH). Complement component 4 (C4), an important component of complement cascade, has been associated with severity of neurological impairment
Moxin Wu, Moxin Wu, Kai Chen, Min Jiang, Fusheng Xie, Xianming Cao, Liang Chen, Zhiying Chen, Zhiying Chen, Xiaoping Yin, Xiaoping Yin   +10 more
doaj   +1 more source

Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (Cyprinus carpio)

Journal of Marine Science and Engineering, 2023
In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah, Akira Yamamoto, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao   +4 more
doaj   +1 more source

SERUM C3 AND SERUM C4 COMPLEMENT IN PATIENTS WITH BURN TRAUMA AND CORRELATION WITH BURN INJURY SEVERITY

Sanamed, 2022
Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
doaj   +1 more source

Associations Between Genotype and Peripheral Complement Proteins in First-Episode Psychosis: Evidences From C3 and C4

Frontiers in Genetics, 2021
Schizophrenia is a common neuropsychiatric disorder with complex pathophysiology. Recent reports suggested that complement system alterations contributed to pathological synapse elimination that was associated with psychiatric symptoms in schizophrenia ...
Yu Chen, Yu Chen, Zhenguo Zhao, Zhenguo Zhao, Fen Lin, Fen Lin, Lifang Wang, Lifang Wang, Zheng Lin, Weihua Yue, Weihua Yue, Weihua Yue   +11 more
doaj   +1 more source

The Assessment of Complement Proteins in Patients With Severe COVID-19 [PDF]

International Journal of Basic Science in Medicine, 2021
Introduction: The complement system, consisting of more than 20 soluble proteins, has a crucial role in innate immunity and inflammation and eliminates pathogens and viral infections.
Ali Ghazavi, Ghasem Mosayebi, Nafiesh Keshavarzian, Somayeh Rabiemajd, Ali Ganji   +4 more
doaj   +1 more source

Complement content in plasma under different storage conditions

Zhongguo shuxue zazhi, 2023
Objective To investigate the changes in complement content in component blood before blood transfusion. Methods 180 samples from 20 plasma donors were collected at different stages of the preparation process, stored at different temperatures and time ...
Zhi HAN, Yujie HAN, Haihong ZHANG
doaj   +1 more source

Ultra-hard rhombohedral carbon from crystal chemistry rationale and first principles [PDF]

Journal of Solid State Chemistry, 302, 122354 (2021), 2021
A new ultra-hard rhombohedral carbon rh-C4 (or hexagonal h-C12) is reported as derived from 3R graphite through crystal chemistry construction and ground state energy within the density functional theory. An extended hexagonal three-dimensional network of h-C12 is formed of C4 tetrahedra alike in h-C4 lonsdaleite (hexagonal diamond).
arxiv   +1 more source

Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4. [PDF]

PLoS ONE, 2013
BACKGROUND: It has been hypothesized that persistent hepatitis C virus (HCV) infection is mediated in part by viral proteins that abrogate the host immune response, including the complement system, but the precise mechanisms are not well understood.
Seiichi Mawatari, Hirofumi Uto, Akio Ido, Kenji Nakashima, Tetsuro Suzuki, Shuji Kanmura, Kotaro Kumagai, Kohei Oda, Kazuaki Tabu, Tsutomu Tamai, Akihiro Moriuchi, Makoto Oketani, Yuko Shimada, Masayuki Sudoh, Ikuo Shoji, Hirohito Tsubouchi   +15 more
doaj   +1 more source

Hypocomplementemia during tocilizumab treatment

Medicine, 2022
. Hypocomplementemia has been reported in patients with rheumatoid arthritis treated with tocilizumab (TCZ), but its long-term consequences are unknown.
Amir Bieber, MD, Doron Markovits, MD, PhD, Kohava Toledano, MD, Yonit Tavor, MD, Reuven Mader, MD, Alexandra Balbir-Gurman, MD, Yolanda Braun-Moscovici, MD   +6 more
doaj   +1 more source