Results 1 to 10 of about 905,894 (352)

Complement C4, Infections, and Autoimmune Diseases [PDF]

Frontiers in Immunology, 2021
Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang, Hongbin Wang, Hongbin Wang, Mengyao Liu   +3 more
doaj   +7 more sources

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage [PDF]

Frontiers in Aging Neuroscience, 2023
ObjectiveThe complement cascade is activated and contributes to the brain injury after intracerebral hemorrhage (ICH). Complement component 4 (C4), an important component of complement cascade, has been associated with severity of neurological impairment
Moxin Wu, Moxin Wu, Kai Chen, Min Jiang, Fusheng Xie, Xianming Cao, Liang Chen, Zhiying Chen, Zhiying Chen, Xiaoping Yin, Xiaoping Yin   +10 more
doaj   +3 more sources

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. [PDF]

Arthritis Rheumatol, 2022
Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation is connected to the autoimmune repertoire in
Lundtoft C, Pucholt P, Martin M, Bianchi M, Lundström E, Eloranta ML, Sandling JK, Sjöwall C, Jönsen A, Gunnarsson I, Rantapää-Dahlqvist S, Bengtsson AA, Leonard D, Baecklund E, Jonsson R, Hammenfors D, Forsblad-d'Elia H, Eriksson P, Mandl T, Magnusson Bucher S, Norheim KB, Auglaend Johnsen SJ, Omdal R, Kvarnström M, Wahren-Herlenius M, Notarnicola A, Andersson H, Molberg Ø, Diederichsen LP, Almlöf J, Syvänen AC, Kozyrev SV, Lindblad-Toh K, DISSECT Consortium, ImmunoArray Development Consortium, Nilsson B, Blom AM, Lundberg IE, Nordmark G, Diaz-Gallo LM, Svenungsson E, Rönnblom L.   +41 more
europepmc   +2 more sources

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects. [PDF]

Int J Mol Sci, 2021
In recent years, accumulating evidence has shown that the innate immune complement system is involved in several aspects of normal brain development and in neurodevelopmental disorders, including autism spectrum disorder (ASD).
Mansur F, Teles E Silva AL, Gomes AKS, Magdalon J, de Souza JS, Griesi-Oliveira K, Passos-Bueno MR, Sertié AL.   +7 more
europepmc   +2 more sources

Low copy numbers of complement <i>C4</i> and <i>C4A</i> deficiency are risk factors for myositis, its subgroups and autoantibodies. [PDF]

Ann Rheum Dis, 2023
Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle ...
Zhou D, King EH, Rothwell S, Krystufkova O, Notarnicola A, Coss S, Abdul-Aziz R, Miller KE, Dang A, Yu GR, Drew J, Lundström E, Pachman LM, Mamyrova G, Curiel RV, De Paepe B, De Bleecker JL, Payton A, Ollier W, O'Hanlon TP, Targoff IN, Flegel WA, Sivaraman V, Oberle E, Akoghlanian S, Driest K, Spencer CH, Wu YL, Nagaraja HN, Ardoin SP, Chinoy H, Rider LG, Miller FW, Lundberg IE, Padyukov L, Vencovský J, Lamb JA, Yu CY, for MYOGEN Investigators.   +38 more
europepmc   +2 more sources

Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder [PDF]

Neuropsychiatric Disease and Treatment, 2021
Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of ...
Pan C, Zhao Y, Xie H, Zhou Y, Duan R, Li Y, Jia Y, Peng T   +7 more
doaj   +2 more sources

Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson’s disease [PDF]

npj Parkinson's Disease
Complement C4, implicated in neuroinflammation and synaptic dysfunction, plays a poorly defined role in Parkinson’s disease (PD). Here, we demonstrate elevated C4 levels in PD patient plasma and the substantia nigra of α-synuclein preformed fibril (α-syn
Wenkai Zou, Liang Kou, Yiming Wang, Zongjie Jin, Nian Xiong, Tao Wang, Yun Xia   +6 more
doaj   +2 more sources

Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study. [PDF]

BMC Nephrol, 2019
BackgroundIgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity and progression of IgAN patients ...
Bi TD, Zheng JN, Zhang JX, Yang LS, Liu N, Yao L, Liu LL.   +6 more
europepmc   +2 more sources

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus. [PDF]

Lupus, 2018
Objectives Low copy numbers and deletion of complement C4 genes are potent risk factors for systemic lupus erythematosus (SLE). However, it is not known whether this genetic association affects the clinical outcome.
Jüptner M, Flachsbart F, Caliebe A, Lieb W, Schreiber S, Zeuner R, Franke A, Schröder JO.   +7 more
europepmc   +2 more sources

Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus [PDF]

Journal of Experimental Medicine, 1990
The two genes for the C4A and C4B isotypes of the fourth component of human complement are located in the MHC class III region. Previous studies have demonstrated the unusual expression of C4 genes in the form of aberrant or duplicated haplotypes.
L. Braun, P. Schneider, C. Giles, J. Bertrams, C. Rittner   +4 more
semanticscholar   +2 more sources