Plasmin as a complement C5 convertase [PDF]
EBioMedicine, 2016 Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together
Lawrence L. Leung, John Morser
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Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis [PDF]
Molecular Therapy: Nucleic Acids, 2023 Complement component 5 (C5), an important molecule in the complement cascade, blockade by antibodies shows clinical efficacy in treating complement-mediated disorders.
Yoshikazu Kuboi +11 more
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Complement C5 inhibition in early onset HELLP syndrome [PDF]
Blood AdvancesGloria F. Gerber +2 more
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Complement C5 inhibition reverses bleomycin-induced thrombotic microangiopathy. [PDF]
Clin Kidney J, 2021 Abstract Whether C5 blocking may improve the outcomes of patients developing chemotherapy-induced thrombotic microangiopathy (TMA) remains elusive. Lung fibrosis is a well-known complication of bleomycin, whereas TMAs are very rare (<20 cases described).
Salhi S, Ribes D, Faguer S.
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Complement C3 and C5 deficiency affects fracture healing. [PDF]
PLoS ONE, 2013 There is increasing evidence that complement may play a role in bone development. Our previous studies demonstrated that the key complement receptor C5aR was strongly expressed in the fracture callus not only by immune cells but also by bone cells and ...
Christian Ehrnthaller +10 more
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The role of microglia and complement C5/C5a in the pathogenesis of rhegmatogenous retinal detachment with choroidal detachment [PDF]
Computational and Structural Biotechnology JournalBackground: Rhegmatogenous retinal detachment with choroidal detachment (RRDCD) is an uncommon and sight-threatening disorder marked by fast development and significant inflammation.
Huiyan Xu +5 more
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Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice [PDF]
Frontiers in Immunology, 2018 Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
Sidonia Mihai +11 more
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The allosteric modulation of complement C5 by knob domain peptides. [PDF]
Elife, 2021 To overcome limited germline combinatorial diversity, bovines have evolved a subset of antibodies with ultra-long CDRH3 regions that harbour cysteine-rich knob domains. To produce affinity-maturated peptides, we previously isolated autonomous 3-6 kDa knob domains from bovine antibodies.
Macpherson A +17 more
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Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice [PDF]
Scientific Reports, 2021 The complement system plays a role in the formation of sub-retinal pigment epithelial (RPE) deposits in early stages of age-related macular degeneration (AMD).
Donita L. Garland +2 more
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The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria. [PDF]
Blood, 2020 Abstract Complement C5 inhibition is the standard of care (SoC) for patients with paroxysmal nocturnal hemoglobinuria (PNH) with significant clinical symptoms. Constant and complete suppression of the terminal complement pathway and the high serum concentration of C5 pose challenges to drug development that result in IV-only treatment ...
Röth A +27 more
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