Results 11 to 20 of about 110,790 (277)

Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage. [PDF]

Transl Stroke Res, 2020
AbstractPrevious studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement expression in brain tissue of
van Dijk BJ, Meijers JCM, Kloek AT, Knaup VL, Rinkel GJE, Morgan BP, van der Kamp MJ, Osuka K, Aronica E, Ruigrok YM, van de Beek D, Brouwer M, Pekna M, Hol EM, Vergouwen MDI.   +14 more
europepmc   +7 more sources

Structural basis for therapeutic inhibition of complement C5. [PDF]

Nat Struct Mol Biol, 2016
Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been demonstrated by eculizumab, one of the world's most expensive drugs. However, the mechanism of C5 activation by C5 convertases remains elusive, thus limiting development of ...
Jore MM, Johnson S, Sheppard D, Barber NM, Li YI, Nunn MA, Elmlund H, Lea SM.   +7 more
europepmc   +5 more sources

Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies [PDF]

Blood Advances, 2018
: The complement and coagulation cascades interact at multiple levels in thrombosis and inflammatory diseases. In venous thrombosis, complement factor 3 (C3) is crucial for platelet and tissue factor (TF) procoagulant activation dependent on protein ...
Nadine Müller-Calleja, Svenja Ritter, Anne Hollerbach, Tanja Falter, Karl J. Lackner, Wolfram Ruf   +5 more
doaj   +2 more sources

Complement profiling for treatment outcomes in pulmonary TB [PDF]

Frontiers in Immunology
IntroductionThe complement system plays a vital role in the immune response against tuberculosis (TB), aiding in the recognition and clearance of Mycobacterium tuberculosis.
Nathella Pavan Kumar, Nathella Pavan Kumar, Arul Nancy P., Arul Nancy P., Syed Hissar, Shanmugam Sivakumar, Vijay Viswanathan, Ramalingam Bethunaickan, Ramalingam Bethunaickan, Hardy Kornfeld, Subash Babu, Subash Babu   +11 more
doaj   +2 more sources

Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis

Frontiers in Immunology, 2022
PurposeSynovial inflammation in knee osteoarthritis (OA) causes disorganized synovial angiogenesis and complement activation in synovial fluid, but links between complement and synovial microvascular pathology have not been established.
Emily U. Sodhi, Holly T. Philpott, Holly T. Philpott, McKenzie M. Carter, McKenzie M. Carter, Trevor B. Birmingham, Trevor B. Birmingham, C. Thomas Appleton, C. Thomas Appleton, C. Thomas Appleton, C. Thomas Appleton   +10 more
doaj   +1 more source

Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation

Frontiers in Immunology, 2023
IntroductionThe complement system is a key component of the innate immune system, and its aberrant activation underlies the pathophysiology of various diseases.
Guo-Qing Tang, Yalan Tang, Ketki Dhamnaskar, Michelle D. Hoarty, Rohit Vyasamneni, Douangsone D. Vadysirisack, Zhong Ma, Nanqun Zhu, Jian-Guo Wang, Charlie Bu, Bestine Cong, Elizabeth Palmer, Petra W. Duda, Camil Sayegh, Alonso Ricardo   +14 more
doaj   +1 more source

Complement C5 Mediates Experimental Tubulointerstitial Fibrosis [PDF]

Journal of the American Society of Nephrology, 2007
Renal fibrosis is the final common pathway of most progressive renal diseases. C5 was recently identified as a risk factor for liver fibrosis. This study investigated the role of C5 in the development of renal tubulointerstitial fibrosis by (1) induction of renal fibrosis in wild-type and C5(-/-) mice by unilateral ureteral ligation (UUO) and (2 ...
Peter, Boor, Andrzej, Konieczny, Luigi, Villa, Anna-Lisa, Schult, Eva, Bücher, Song, Rong, Uta, Kunter, Claudia R C, van Roeyen, Thomas, Polakowski, Heiko, Hawlisch, Sonja, Hillebrandt, Frank, Lammert, Frank, Eitner, Jürgen, Floege, Tammo, Ostendorf   +14 more
openaire   +3 more sources

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells

Cells, 2023
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus ...
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner   +6 more
doaj   +1 more source

Recurrent hemolytic uremic syndrome caused by gene mutation: a case report [PDF]

Childhood Kidney Diseases, 2022
Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury without any association with preceding diarrhea.
Baek Sup Shin, Yo Han Ahn, Hee Gyung Kang   +2 more
doaj   +1 more source

Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy

Biomedicines, 2022
The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino, Fiammetta Vanoli, Rita Frangiamore, Marta Ballardini, Letizia Scandiffio, Federica Bortone, Francesca Andreetta, Fulvio Baggi, Pia Bernasconi, Carlo Antozzi, Paola Cavalcante, Renato Mantegazza   +11 more
doaj   +1 more source