Results 91 to 100 of about 38,195 (255)
Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy?
BiologyEmerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins +5 more
doaj +1 more source
Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]
, 1990 Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H. +3 more
core +1 more source
Complement-targeted therapy: development of C5- and C5a-targeted inhibition [PDF]
Inflammation and Regeneration, 2016 The complement system is a major effector of humoral immunity and natural immunity. The complement system has three independent pathways of complement activation: a classical pathway, an alternative pathway, and a lectin pathway. These pathways converge to a common pathway that activates C3. This pathway also leads to the formation of various bioactive
Horiuchi, Takahiko, Tsukamoto, Hiroshi
openaire +2 more sources
Complement C5a receptors in the pituitary gland: expression and function [PDF]
Journal of Endocrinology, 2008 Communication between the immune and endocrine system is important for the control of inflammation that is primarily mediated through the hypothalamic–pituitary–adrenal axis. The innate immune system rapidly responds to pathogens by releasing complement proteins that include the anaphylatoxins C3a and C5a.
Karen, Francis +3 more
openaire +2 more sources
Epilepsia Open, EarlyView.Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira +5 more
wiley +1 more source
Ibrain, EarlyView.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Complement C5A regulates prolabor mediators in human placenta.
Biology of reproduction, 2012 Human preterm and term parturition is associated with inflammatory cascades in the uteroplacental unit. Activation of the complement cascade releases potent proinflammatory mediators, including the anaphylatoxin C5a, which exerts its biological effects through its receptors, C5AR (also known as CD88) and C5L2, official symbol GPR77.
Lappas, Martha +3 more
openaire +3 more sources
Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]
, 2004 Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas D +5 more
core +3 more sources
CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a [PDF]
Journal of Immunology Research, 2015 CYP4Fs were first identified as enzymes that catalyze hydroxylation of leukotriene B4(LTB4). CYP4F18 has an unusual expression in neutrophils and was predicted to play a role in regulating LTB4-dependent inflammation. We compared chemotaxis of wild-type andCyp4f18knockout neutrophils using anin vitroassay.
Rachel Vaivoda +4 more
openaire +3 more sources
Beyond feasibility filters: How expertise heterogeneity enables innovation recognition
Strategic Management Journal, EarlyView.Abstract Research Summary Organizations often struggle to identify promising innovations that balance novelty and feasibility in multidisciplinary domains, yet how does evaluator expertise heterogeneity shape these assessments? This study examines how evaluator expertise influences innovation evaluation through a field experiment with National ...
Jacqueline N. Lane +3 more
wiley +1 more source