Results 101 to 110 of about 38,195 (255)
Frontiers in Molecular Neuroscience, 2017 Hereditary ATTR V30M amyloidosis is a lethal autosomal dominant sensorimotor and autonomic neuropathy caused by deposition of aberrant transthyretin (TTR).
Eleni Fella +11 more
doaj +1 more source
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]
, 2019 Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P +11 more
core +3 more sources
Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation
Small, EarlyView.This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori +8 more
wiley +1 more source
Terminal complement activation is increased and associated with disease severity in CIDP [PDF]
, 2016 Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic autoimmune neuropathy. While both cell-mediated and humoral mechanisms contribute to its pathogenesis, the rapid clinical response to plasmapheresis implicates a ...
Hiepe, Falk +4 more
core +1 more source
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
Allergy, EarlyView.Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong +217 more
wiley +1 more source
Journal of Translational Medicine, 2011 Background Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pathogenesis.
Klein Michael L +12 more
doaj +1 more source
The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
Integrating Dialysis in Ex Situ Machine Perfusion: A Systematic Review and Meta‐Analysis of Outcomes
Artificial Organs, EarlyView.Dialysis‐enhanced EVMP effectively maintains biochemical homeostasis, potentially mitigating metabolic stress and extending perfusion duration. Functional outcomes varied depending on the organ type, with the most pronounced benefits observed in cardiac perfusion.
Yomna E. Dean +12 more
wiley +1 more source
Placental Malaria: From Infection to Malfunction [PDF]
, 2006 Malaria during pregnancy is a major factor in infant morbidity and mortality. In this issue of Cell Host and Microbe, Conroy et al. (2013) propose that C5a, a product of complement cascade activation, counteracts the placental vascular remodeling ...
Luciana Vieira de Moraes +11 more
core +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich +7 more
wiley +1 more source