Results 51 to 60 of about 38,195 (255)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation

BMC Oral Health, 2021
Background During the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the complement cascade.
Jie Liu, Xiaoling Wei, Junlong Hu, Xiaohan Tan, Xiaocui Kang, Li Gao, Ning Li, Xin Shi, Mengtong Yuan, Weiping Hu, Mingyue Liu   +10 more
doaj   +1 more source

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

Frontiers in Immunology, 2021
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi   +6 more
doaj   +1 more source

Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis

Clinical Immunology
Clinical data and animal models have provided compelling evidence supporting the pathogenic role of complement activation in the progression of focal segmental glomerulosclerosis (FSGS). However, the mechanisms underlying complement-induced podocyte injury and parietal epithelial cell (PEC) activation are not well understood.We evaluated glomerular ...
Xiaojie Gong, Jing Huang, Yue Shu, Miao Wang, Jing Ji, Li Yang, Ming‐Hui Zhao, Zhao Cui   +7 more
openalex   +3 more sources

SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate

Clinical & Translational Immunology, 2022
Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect.
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff   +10 more
doaj   +1 more source

Drusen complement components C3a and C5a promote choroidal neovascularization [PDF]

Proceedings of the National Academy of Sciences, 2006
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark of AMD is the presence of drusen, extracellular deposits that accumulate beneath the retinal pigmented epithelium.
Miho, Nozaki, Brian J, Raisler, Eiji, Sakurai, J Vidya, Sarma, Scott R, Barnum, John D, Lambris, Yali, Chen, Kang, Zhang, Balamurali K, Ambati, Judit Z, Baffi, Jayakrishna, Ambati   +10 more
openaire   +2 more sources

Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin

EBioMedicine, 2016
Thrombus formation leading to vaso-occlusive events is a major cause of death, and involves complex interactions between coagulation, fibrinolytic and innate immune systems.
Jonathan H. Foley, Bethany L. Walton, Maria M. Aleman, Alice M. O'Byrne, Victor Lei, Micaela Harrasser, Kimberley A. Foley, Alisa S. Wolberg, Edward M. Conway   +8 more
doaj   +1 more source

Non-invasive monitoring of renal transplant recipients: Urinary excretion of soluble adhesion molecules and of the complement-split product C4d [PDF]

, 2003
Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection.
Friedrich, N., Getto, R., Lederer, Stephan R., Regenbogen, C., Sitter, Thomas, Toepfer, Marcel   +5 more
core   +1 more source

Complement C5a receptors C5L2 and C5aR in renal fibrosis [PDF]

American Journal of Physiology-Renal Physiology, 2018
Complement factor C5a has two known receptors, C5aR, which mediates proinflammatory effects, and C5L2, a potential C5a decoy receptor. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney. Here we tested for the first time the role of C5L2 in renal fibrosis.
Ina V. Martin, Annika Bohner, Peter Boor, Erdenechimeg Shagdarsuren, Ute Raffetseder, Frank Lammert, Jürgen Floege, Tammo Ostendorf, Susanne N. Weber   +8 more
openaire   +2 more sources

The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura. [PDF]

PLoS ONE, 2015
In addition to IgA, the deposition of complement (C)3 in dermal vessels is commonly found in Henoch-Schönlein purpura (HSP). The aim of this study is to elucidate the role of circulating complement proteins in the pathogenesis of childhood HSP.Plasma ...
Yao-Hsu Yang, I-Jung Tsai, Chun-Jung Chang, Ya-Hui Chuang, Hui-Yao Hsu, Bor-Luen Chiang   +5 more
doaj   +1 more source