Results 121 to 130 of about 11,877 (255)
Advances in cryo-EM that have shaped mechanistic models of membrane-attack-complex assembly and regulation. [PDF]
IUCrJNoone DP, Bubeck D.
europepmc +1 more source
A disulfide linked model of the complement protein C8 gamma complexed with C8 alpha indel peptide
, 2009 In a recent study C8 gamma (complement protein) with Cys40Ala substitution and a C8 alpha derived peptide with Cys164Ala substitution were co-crystallized and their binding mode was revealed. Computer modeling and molecular dynamics simulations were performed in order to check the hypothesis that the residues Ala164 of C8 alpha and Ala40 of C8 gamma ...
openaire +1 more source
Human Sustainability Leadership and Employee Wellbeing (Flourishing) in Organizations
Sustainable Development, EarlyView.ABSTRACT This qualitative case study research examines how designing for human sustainability leadership (HSL) affects employee wellbeing (flourishing) (HWBF) in organizations. It is undertaken at a university in the United Kingdom including academics and administrators.
Elli Meleti
wiley +1 more source
Sustainable Development, EarlyView.ABSTRACT Eco‐Industrial Parks (EIPs) are critical infrastructure for transitioning to sustainable production and consumption patterns, enabling resource efficiency through industrial symbiosis. However, the success of these circular ecosystems depends heavily on strategic location planning that balances conflicting economic, environmental, and social ...
Ertugrul Ayyildiz, Betul Sasmazturk
wiley +1 more source
Small, EarlyView.Cationic lipopeptides self‐assemble into stable, cell‐like vesicles that merge peptide programmability with lipid self‐organization. These biocompatible compartments efficiently sequester and deliver nucleic acids, enabling high transfection efficiency with low‐toxicity in both HEK293T cells and mesenchymal stem cells (MSCs).
Federica A. Souto‐Trinei +4 more
wiley +1 more source
Small, EarlyView.The UOR mechanism on Pt, Ni, and PtNi surfaces shows that at low potentials, only Pt/C and PtNi/C are active, promoting the formation of N2 as the dominant product. At higher potentials, C–N bond cleavage becomes predominant, and NO intermediates drive the formation of NO2− as the main product on PtNi/C and Ni/C.
Rodrigo G. de Araujo +4 more
wiley +1 more source
Nonlinear analysis of flat post‐tensioned concrete slab–edge column connections
Structural Concrete, EarlyView.Abstract This study presents nonlinear finite element analyses to investigate the punching shear behavior of unbonded post‐tensioned concrete flat slabs at slab‐edge column connections. A parametric analysis was conducted to evaluate the influence of four critical parameters on the punching shear resistance: the distribution of prestressing tendons ...
Igor Gonçalves +4 more
wiley +1 more source
Seismic evaluation of the southbound Stellenberg Interchange Bridge, B5593, in South Africa
Structural Concrete, EarlyView.Abstract This study presents a nonlinear finite element assessment of the seismic vulnerability of Bridge B5593, located in the south‐western region of South Africa. Previous evaluations identified a high likelihood of column failure; however, these were based on linear material models incapable of capturing damage evolution.
Wandie Olivier, Trevor Haas
wiley +1 more source
Assessing Capability Complexity Using Enterprise Architecture Framework
Systems Engineering, EarlyView.ABSTRACT This study proposes a structured and quantitative methodology to evaluate the holistic complexity of system‐of‐systems (SoSs), employing the Zachman Architecture Framework (ZAF) as its foundational analytical tool. A five‐phase analytical procedure is developed and empirically validated, encompassing: (1) refinement of complexity measures, (2)
Javad Bakhshi, Mahmoud Efatmaneshnik
wiley +1 more source
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source