Results 121 to 130 of about 47,794 (286)

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Parallel Analysis of Acidic and Basic Proteoforms in Cell Lysates via Native Cation and Anion Exchange Chromatography—Native Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Comprehensive characterization of proteoforms in complex biological systems remains a significant challenge. While native ion‐exchange chromatography (IEC) hyphenated with native mass spectrometry (nMS) is a powerful tool for resolving proteoforms, three critical limitations persist: restricted volatile buffers causing nonlinear pH gradients ...
Ziran Zhai, Hafsa Zakri, Matteo Damian, Francesco G. Mutti, Garry Corthals, Andrea F. G. Gargano   +5 more
wiley   +1 more source

Anti‐Allergic Potential of Chamaecrista nomame and Its Compound Luteolin for Novel Asthma Therapy

Phytotherapy Research, EarlyView.
Chamaecrista nomame (CN) and its active compound luteolin attenuate allergic airway inflammation by inhibiting mast cell activation and suppressing NF‐κB/MAPK signaling, leading to reduced cytokine production and OVA‐specific IgE levels. ABSTRACT Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation ...
Tae Kyeom Kang, Myungsuk Kim, Tam Thi Le, Geon Park, Yuna Jung, Hyobin Jeong, Youngsang Yoo, Wook‐Bin Lee, Sang Hoon Jung   +8 more
wiley   +1 more source

Advanced design and application for viologen‐based redox devices with customizable functionalities

Responsive Materials, EarlyView.
This review examines viologen‐based materials with customizable functionalities achieved through molecular engineering strategies such as side‐chain modification and composite formation. It emphasizes their utility in electrochromic devices, multicolor displays, and energy storage, while discussing stability challenges and outlining future development ...
Yuxin Chang, Yuchen Ge, Luzi Wang, Jinqian Mao, Zhongzhi Qu, Na Li, Dongqi Liu, Jiupeng Zhao   +7 more
wiley   +1 more source

Nonlinear analysis of flat post‐tensioned concrete slab–edge column connections

Structural Concrete, EarlyView.
Abstract This study presents nonlinear finite element analyses to investigate the punching shear behavior of unbonded post‐tensioned concrete flat slabs at slab‐edge column connections. A parametric analysis was conducted to evaluate the influence of four critical parameters on the punching shear resistance: the distribution of prestressing tendons ...
Igor Gonçalves, Ricardo Randi, Orlando M. Almeida, Elyson A. P. Liberati, Leandro M. Trautwein   +4 more
wiley   +1 more source

Seismic evaluation of the southbound Stellenberg Interchange Bridge, B5593, in South Africa

Structural Concrete, EarlyView.
Abstract This study presents a nonlinear finite element assessment of the seismic vulnerability of Bridge B5593, located in the south‐western region of South Africa. Previous evaluations identified a high likelihood of column failure; however, these were based on linear material models incapable of capturing damage evolution.
Wandie Olivier, Trevor Haas
wiley   +1 more source

Assessing Capability Complexity Using Enterprise Architecture Framework

Systems Engineering, EarlyView.
ABSTRACT This study proposes a structured and quantitative methodology to evaluate the holistic complexity of system‐of‐systems (SoSs), employing the Zachman Architecture Framework (ZAF) as its foundational analytical tool. A five‐phase analytical procedure is developed and empirically validated, encompassing: (1) refinement of complexity measures, (2)
Javad Bakhshi, Mahmoud Efatmaneshnik
wiley   +1 more source

Mitochondrial DNA HVRII (Poly-C) and HVRIII (Poly-CA) tandem repeat variation in the Koraga population

Egyptian Journal of Medical Human Genetics
Background In situations where nuclear DNA samples are limited or degraded, mitochondrial DNA can be used as an alternative for forensic applications.
Swathy Krishna, Jaison Jeevan Sequeira, Mohammed S. Mustak, Ranajit Das   +3 more
doaj   +1 more source

Inflation Propagation in Production

Australian Economic Review, EarlyView.
ABSTRACT Background Inflationary pressures in an increasingly interconnected production system reflect not only aggregate or isolated sectoral shocks but also their propagation through supply‐chain networks. Methods This paper examines the mechanisms underlying inflation transmission in a small open economy, using industry‐level data for Australian ...
Thuy Hang Duong
wiley   +1 more source