Results 201 to 210 of about 11,452 (258)

Potentiating CD20 monoclonal antibody therapy by targeting complement C3 fragments covalently deposited on lymphoma cells.

Blood
Baskar S, Peng H, Gaglione EM, Carstens EJ, Lindorfer MA, Ahn IE, Herman SEM, Skarzynski M, Chang J, Keyvanfar K, Butera V, Blackburn A, Vire B, Maric I, Stetler-Stevenson M, Yuan CM, Eckhaus MA, Soto S, Farooqui MZH, Taylor RP, Rader C, Wiestner A.   +21 more
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An indel within the C8 alpha subunit of human complement C8 mediates intracellular binding of C8 gamma and formation of C8 alpha-gamma.

Biochemistry, 2000
Human C8 is one of five complement components (C5b, C6, C7, C8, and C9) that interact to form the cytolytic membrane attack complex, or MAC. It is an oligomeric protein composed of three subunits (C8alpha, C8beta, C8gamma) that are products of different genes.
M E, Plumb, J M, Sodetz
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Genetic polymorphism of complement component C8

Human Genetics, 1985
Extensive genetic polymorphism of complement component C8 was demonstrated by isoelectric focusing of serum or plasma samples followed by immunoblotting procedures. Using these methods, we could detect both alpha-gamma (C81) and beta (C82) chain polymorphisms in the same gel.
S, Rogde, B, Mevåg, P, Teisberg, T, Gedde-Dahl, F, Tedesco, B, Olaisen   +5 more
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Blocking Complement-Mediated Hemolysis Using RNA Aptamers That Bind Complement Component C8.

Blood, 2005
Abstract A recent pilot study in patients with paroxysmal nocturnal hemoglobinuria (PNH), using a humanized monoclonal antibody that binds human complement C5 and inhibits terminal complement protein activation, suggests that blocking complement is a potentially effective therapeutic option for PNH.
Jun-ichi Nishimura, Shahid M. Nimjee, Haixiang Jiang, Thad A. Howard, George A. Pitoc, Christopher P. Rusconi, Mitsuhiro Omine, Nelson J. Chao, Michael M. Frank, Bruce A. Sullenger, Russell E. Ware   +10 more
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Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59

Molecular Immunology, 2020
Complement C8, as a main component of the membrane attack complex, has only been identified in vertebrates. C8 comprises three subunits encoded by individual genes: C8a (alpha chain), C8b (beta chain), and C8g (gamma chain). However, in fish, there have been limited studies on the evolutionary history and systematic function of C8. In the present study,
Lisen, Li, Weining, Yang, Yubang, Shen, Xiaoyan, Xu, Jiale, Li   +4 more
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Genetic basis of human complement C8 beta deficiency.

The Journal of Immunology, 1993
Abstract The eighth component of human complement (C8) is a serum protein consisting of three chains (alpha, beta, and gamma) and encoded by three different genes, C8A, C8B, and C8G. C8A and C8B are closely linked on chromosome 1p, whereas C8G is located on chromosome 9q.
T, Kaufmann, G, Hänsch, C, Rittner, P, Späth, F, Tedesco, P M, Schneider   +5 more
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Complement C8 deficiency with recurrent meningococcemia: Examination of meningococcal opsonization

Journal of Paediatrics and Child Health, 1985
Abstract A 10 year old girl presented with recurrent febrile episodes over 2 months. A non‐typable strain of Neisseria meningitidis was grown from blood cultures on three occasions. She was found to lack functional C8 activity in serum but material with C8 antigenic activity was present. The opsonic activity of the C8 deficient serum for N. meningidis
A S, Kemp, J, Vernon, H J, Muller-Eberhard, D C, Bau   +3 more
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The Terminal Complement Complex in Sera Deficient in the Eighth Component of Complement (C8)

Scandinavian Journal of Immunology, 1986
The terminal complement complex (TCC) was quantified in sera from patients with a genetic deficiency of C8α‐γ or C8β The individual sera contained only trace amounts of TCC compared with a normal serum pool. The content of TCC increased after mixing the two sera, which was consistent with reconstitution of C8 activity.
T E, Mollnes, T, Lea, S, Rogde, F, Tedesco   +3 more
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A familial dysfunction of the eighth component of complement (C8)

Clinical Immunology and Immunopathology, 1980
Abstract A 6-year-old boy, who presented with hepatosplenomegaly, moderately elevated erythrocyte sedimentation rate, hypergammaglobulinemia, and eosinophilia, was found to have very low or undetectable serum C8 hemolytic activity. This activity was restored to normal by the addition of purified C8.
F, Tedesco, M, Bardare, A M, Giovanetti, G, Sirchia   +3 more
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Genetic Aspects of Complement Component C8 in Norwegian Meningococcal Disease Patients

Scandinavian Journal of Infectious Diseases, 1990
Sera from 85 consecutive systemic meningococcal disease patients and 203 matched control individuals were C8 typed. In the patient group, one C8B deficient individual was discovered; none in the control group. No case of C8A deficiency was encountered. The material was collected during a period of epidemic meningococcal disease in Norway, mainly due to
S, Rogde, E A, Høiby, P, Teisberg, B, Olaisen   +3 more
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