Results 241 to 250 of about 47,794 (286)
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The gamma subunit of the eighth complement component (C8) in rainbow trout
Developmental & Comparative Immunology, 2006Of the 35 proteins, enzymes, receptors and regulatory components of the complement system, C8gamma is unique in that it is the only lipocalin. C8gamma is a subunit of the C8 molecule, which is one of the five components (C5b, C6, C7, C8 and C9) that interact as a consequence of complement activation to form the membrane attack complex.
Anastasios D, Papanastasiou +1 more
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Genetic Polymorphisms and Linkage Relations of Complement Factor C8
1985Abstract Genetically determined variation in both the C8α-chain (C81) and β-chain (C82) is detected by isoelectric focusing and imnunoblotting, supplemented by two dimensional electrophoresis. The C81 and C82 loci are closely linked. Both C8 loci are linked to the chromosome 1 marker loci PGM1 and Rh .
S. ROGDE +4 more
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Human complement C81 (C8 A) polymorphism: detection and segregation of new variants
Human Genetics, 1993In addition to the earlier detected C81(A) rare variants A1, A2 (now A3) and B1 (now B2), six new rare variants (C81 A2 new, A4, A5, A6, M1 and B1new) are described within the polymorphism of the eighth component of human complement (alpha-gamma chain subunit). Except for A3, all rare C81 A variants are only detected by isoelectric focusing, and not by
C, Rittner, B, Stradmann-Bellinghausen
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In vitro expression of the beta subunit of human complement component C8
Molecular Immunology, 1996Human C8 is one of five components of the cytolytic C5b-9 complex of complement. It is an oligomeric protein composed of three subunits (alpha, beta, gamma) encoded in separate genes. These are arranged as a disulfide-linked alpha-gamma dimer and a noncovalently associated beta chain.
C S, Letson, K M, Kaufman, J M, Sodetz
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Lymphocyte‐Associated Complement: Role of C8 in Certain Cell‐mediated Lytic Reactions
Scandinavian Journal of Immunology, 197451Cr‐ labelled chicken erythrocytes (E) were treated with human and C7 to form , susceptible to lysis by the terminal complement components C8 and C9 ('reactive lysis') Addition of purified and extensively washed human blood lymphocytes, but not of erythrocytes, to resulted in a similar but cell‐mediated reactive lysis. Contamination of the effector
P, Perlmann, H, Perlmann, P, Lachmann
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Homologous restriction factor: Effect on complement C8 and C9 uptake and lysis
Molecular Immunology, 1994Homologous restriction factor (HRF) is a complementary regulatory protein found on the surface of human erythrocytes and other cell types. It has the function of blocking the lytic action of the membrane attack complex (MAC) of complement when incorporated into a membrane.
L S, Zalman, H, Müller-Eberhard
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Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families
European Journal of Pediatrics, 1992Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second family, two children had C8 deficiency and one child in a third family had C3 deficiency. The index cases were identified during screening of patients with recurrent pyogenic infections, recurrent meningitis and ...
O, Sanal +5 more
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The Journal of Immunology, 1979
Abstract Inhibitors of the fluid phase complex were examined in serum from which the lipoproteins had been removed. A limited number of these nonlipoprotein inhibitors were observed, and one was shown to be C8 by several criteria.
G R, Nemerow, K I, Yamamoto, T F, Lint
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Abstract Inhibitors of the fluid phase complex were examined in serum from which the lipoproteins had been removed. A limited number of these nonlipoprotein inhibitors were observed, and one was shown to be C8 by several criteria.
G R, Nemerow, K I, Yamamoto, T F, Lint
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Complementary DNA cloning of complement C8.beta. and its sequence homology to C9
Biochemistry, 1987The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions.
J A, Haefliger +6 more
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Human Alveolar Macrophages Synthesize Active Complement Components C6, C7, and C8 in Vitro
Scandinavian Journal of Immunology, 1987We investigated whether serum‐free human alveolar macrophage cultures synthesize aetive C6. C7. and C8. There was a significant binding of polyclonal anti‐human C6 antibodies to agarose beads incubated with unstimulated macrophages for 24 or 48 h. Endotoxin stimulation of the macrophages was necessary for significant binding of polyclonal anti‐C7 and ...
H B, Pettersen, E, Johnson, G, Hetland
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