Results 61 to 70 of about 47,794 (286)

Systemic immune parameters after prior radiation therapy in patients receiving immune checkpoint inhibitors

Translational Oncology, 2023
Introduction: Preclinical studies have demonstrated the ability of radiation therapy (RT) to augment immune response and tumor control by immune checkpoint inhibitors (ICI).
Vatsala Mundra, Yuqiu Yang, Mitchell S. von Itzstein, Farjana Fattah, Amrit S. Gonugunta, Raquibul Hannan, Laurentiu M. Pop, Yuanyuan Zhang, Yiqing Wang, Thomas Sheffield, Yang Xie, Jonathan E. Dowell, Jade Homsi, Sawsan Rashdan, Jason Park, Quan-Zhen Li, Edward K. Wakeland, David E. Gerber   +17 more
doaj   +1 more source

Band taut sutured manifolds

, 2013
Attaching a 2-handle to a genus two or greater boundary component of a 3-manifold is a natural generalization of Dehn filling a torus boundary component.
Taylor, Scott A.
core   +1 more source

Diagnostic Odyssey of Atypical Long‐Chain 3‐Hydroxyacyl‐CoA Dehydrogenase Deficiency (LCHADD) Explained by Three Allelic Products From Two Pathogenic Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive mitochondrial defect of long‐chain fatty acid β‐oxidation, caused by biallelic pathogenic variants in HADHA or HADHB. We report a 22‐year‐old male with an atypically mild presentation of LCHADD who was referred to the Undiagnosed Diseases Network (UDN ...
Yutaka Furuta, Lynette C. Rives, T. Andrew Burrow, Thomas A. Cassini, Rory J. Tinker, Amy K. Robertson, Kimberly M. Ezell, Rizwan Hamid, Joy D. Cogan, John A. Phillips III   +9 more
wiley   +1 more source

Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Our previous studies showed that Trichinella spiralis paramyosin (TsPmy) is an immunomodulatory protein that inhibits complement C1q and C8/C9 to evade host complement attack.
Lei Wang, Xiaohuan Wang, Kuo Bi, Ximeng Sun, Jing Yang, Yuan Gu, Jingjing Huang, Bin Zhan, Xinping Zhu   +8 more
doaj   +1 more source

(Co)isotropic Pairs in Poisson and Presymplectic Vector Spaces

, 2015
We give two equivalent sets of invariants which classify pairs of coisotropic subspaces of finite-dimensional Poisson vector spaces. For this it is convenient to dualize; we work with pairs of isotropic subspaces of presymplectic vector spaces.
Lorand, Jonathan, Weinstein, Alan
core   +1 more source

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition

Frontiers in Microbiology, 2017
Leptospirosis is a zoonosis caused by spirochetes from the genus Leptospira. This disease is common in tropical and subtropical areas, constituting a serious public health problem.
Thais A. Amamura, Tatiana R. Fraga, Sílvio A. Vasconcellos, Angela S. Barbosa, Lourdes Isaac   +4 more
doaj   +1 more source

The homology of complement factor C8 gamma chain and alpha-1-microglobulin

Biochemical and Biophysical Research Communications, 1987
The sequence of the complement factor C8 gamma chain shares a remarkable degree of similarity with that of alpha-1-microglobulin, a member of the alpha-2u-globulin superfamily. This superfamily comprises a diverse group of distantly related animal proteins possessing characteristic structural features and similar functions.
L T, Hunt, A, Elzanowski, W C, Barker
openaire   +2 more sources

Isolation and Reactivity of a Square‐Planar Trisamido Silane

Angewandte Chemie International Edition, EarlyView.
We report the synthesis and comprehensive characterisation of a square‐planar Si(+IV) hydride supported by an unsymmetric, trianionic and dearomatised N,N,N‐pincer ligand. This system enables element–ligand cooperative reactivity as an alternative to silicon‐centred redox chemistry, illuminating a largely unexplored regime in high‐valent silicon ...
David M. J. Krengel, Xiaobai Wang, Christopher Golz, Regine Herbst‐Irmer, Oliver P. E. Townrow, Malte Fischer   +5 more
wiley   +1 more source

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies

Scientific Reports
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement ...
Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing   +13 more
doaj   +1 more source

Genetic polymorphism in C8 beta-chains. Evidence for two unlinked genetic loci for the eighth component of human complement (C8). [PDF]

Journal of Clinical Investigation, 1983
Genetic polymorphism in the beta-subunit of the eighth component of human complement, C8, was defined by isoelectric focusing of serum in polyacrylamide gel in the presence of urea and development of specific patterns of hemolysis in an overlay gel containing antibody-sensitized erythrocytes and C8 beta-chain-deficient serum. Bands of hemolysis induced
C A, Alper, D, Marcus, D, Raum, B H, Petersen, T J, Spira   +4 more
openaire   +2 more sources