Results 61 to 70 of about 11,877 (255)

Assignment for genes encoding the terminal complement components to porcine chromosome [PDF]

Biotechnology in Animal Husbandry, 2014
One of the major goals of the porcine genome projects is building a physical map. To assign the porcine genes encoding the complement components C6, C7, C8 and C9 to porcine chromosomes, we used a porcine 7000Rad Radiation Hybrid panel (IMpRH) containing
Khoa Anh D.V., Wimmers K.
doaj  

Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7.

PLoS Pathogens, 2020
An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6 ...
Dennis J Doorduijn, Bart W Bardoel, Dani A C Heesterbeek, Maartje Ruyken, Georgina Benn, Edward S Parsons, Bart W Hoogenboom, Suzan H M Rooijakkers   +7 more
doaj   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Advances in BODIPY Derivatives for Antibacterial Phototherapy

Angewandte Chemie, EarlyView.
This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv, Heejeong Kim, Hongchen Zhai, Hanqi Ren, Silu Wang, Cong Sun, Yafu Wang, Hosoowi Lee, Juyoung Yoon, Hua Zhang   +9 more
wiley   +2 more sources

Crystal Structure of the MACPF Domain of Human Complement Protein C8α in Complex with the C8γ Subunit [PDF]

Journal of Molecular Biology, 2008
Human C8 is one of five complement components (C5b, C6, C7, C8, and C9) that assemble on bacterial membranes to form a porelike structure referred to as the "membrane attack complex" (MAC). C8 contains three genetically distinct subunits (C8 alpha, C8 beta, C8 gamma) arranged as a disulfide-linked C8 alpha-gamma dimer that is noncovalently associated ...
Slade, Daniel J., Lovelace, Leslie L., Chruszcz, Maksymilian, Minor, Wladek, Lebioda, Lukasz, Sodetz, James M.   +5 more
openaire   +4 more sources

Efficient Concentration and Complete Destruction of Short‐Chain and Emerging PFAS in Contaminated Water via Integrated Interface Engineering‐Enhanced Carbon Felt Sorption and Photochemical Processes

Advanced Science, EarlyView.
A closed‐loop “Concentrate‐Destroy” strategy is presented for completely eliminating short‐chain and emerging PFAS, in which the new 3D PPy@P‐CF is used for efficiently concentrating PFAS and Cu2+‐mediated photodegradation is applied for the completely destroying PFAS in the sorbent regeneration eluent.
Hao Yu, Jialei Guo, Peng Zhang, Hongyi Li, Feng He, Hongwen Sun   +5 more
wiley   +1 more source

Abundant lipid and protein components of drusen. [PDF]

PLoS ONE, 2010
Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE ...
Lan Wang, Mark E Clark, David K Crossman, Kyoko Kojima, Jeffrey D Messinger, James A Mobley, Christine A Curcio   +6 more
doaj   +1 more source

Systemic immune parameters after prior radiation therapy in patients receiving immune checkpoint inhibitors

Translational Oncology, 2023
Introduction: Preclinical studies have demonstrated the ability of radiation therapy (RT) to augment immune response and tumor control by immune checkpoint inhibitors (ICI).
Vatsala Mundra, Yuqiu Yang, Mitchell S. von Itzstein, Farjana Fattah, Amrit S. Gonugunta, Raquibul Hannan, Laurentiu M. Pop, Yuanyuan Zhang, Yiqing Wang, Thomas Sheffield, Yang Xie, Jonathan E. Dowell, Jade Homsi, Sawsan Rashdan, Jason Park, Quan-Zhen Li, Edward K. Wakeland, David E. Gerber   +17 more
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Our previous studies showed that Trichinella spiralis paramyosin (TsPmy) is an immunomodulatory protein that inhibits complement C1q and C8/C9 to evade host complement attack.
Lei Wang, Xiaohuan Wang, Kuo Bi, Ximeng Sun, Jing Yang, Yuan Gu, Jingjing Huang, Bin Zhan, Xinping Zhu   +8 more
doaj   +1 more source