Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
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Editorial: Function and Dysfunction of Complement Factor H [PDF]
Frontiers in Immunology, 2022 Non peer ...
Mihály Józsi +2 more
doaj +13 more sources
Complement factor H in molecular regulation of angiogenesis [PDF]
Medical ReviewAngiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang +6 more
doaj +4 more sources
Factor H Family Proteins in Complement Evasion of Microorganisms [PDF]
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b. [PDF]
PLoS Pathogens, 2008 The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum.
Katrin Haupt +7 more
doaj +7 more sources
Hijacking Factor H for Complement Immune Evasion [PDF]
Frontiers in Immunology, 2021 The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore +3 more
doaj +3 more sources
Factor H Autoantibodies and Complement-Mediated Diseases [PDF]
Frontiers in Immunology, 2020 Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang +10 more
doaj +5 more sources
Truncated forms of human complement factor H [PDF]
Biochemical Journal, 1989 By the use of Western-blot analyses with polyclonal anti-(Factor H) antibodies, two low-Mr protein species of Mr 41,000 and 37,000 under non-reducing conditions and 43,000 and 40,000 under reducing conditions are consistently detected together with the well-known 155,000-Mr Factor H in human plasma and serum. These two additional species are also found
Marc Fontaine +6 more
openalex +4 more sources
Planar posets have dimension at most linear in their height [PDF]
SIAM Journal on Discrete Mathematics, 31/4:2754--2790, 2018, 2016 We prove that every planar poset $P$ of height $h$ has dimension at most $192h + 96$. This improves on previous exponential bounds and is best possible up to a constant factor. We complement this result with a construction of planar posets of height $h$ and dimension at least $(4/3)h-2$.
Joret, Gwenaël +2 more
arxiv +3 more sources
Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]
Frontiers in Immunology, 2013 Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser +7 more
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