Results 1 to 10 of about 1,235,428 (322)

Complement factor H in molecular regulation of angiogenesis [PDF]

Medical Review
Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju   +6 more
doaj   +4 more sources

Editorial: Function and Dysfunction of Complement Factor H [PDF]

Frontiers in Immunology, 2022
Non peer ...
Mihály Józsi, Paul Nigel Barlow, Seppo Meri   +2 more
doaj   +9 more sources

Microbes bind complement inhibitor factor H via a common site. [PDF]

PLoS Pathogens, 2013
To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri, H Amdahl, M J Lehtinen, S Hyvärinen, J V McDowell, A Bhattacharjee, S Meri, R Marconi, A Goldman, T S Jokiranta   +9 more
doaj   +11 more sources

Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser, Munirah eAbdul-Aziz, Munirah eAbdul-Aziz, Annapurna eNayak, Cordula M Stover, Robert B Sim, Robert B Sim, Uday eKishore   +7 more
doaj   +3 more sources

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]

Frontiers in Immunology
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag   +17 more
doaj   +2 more sources

Protective role of complement factor H against the development of preeclampsia [PDF]

Frontiers in Immunology
Pregnancy is an immunologically regulated, complex process. A tightly controlled complement system plays a crucial role in the successful establishment of pregnancy and parturition.
Hadida Yasmin, Chiara Agostinis, Miriam Toffoli, Tamali Roy, Silvia Pegoraro, Andrea Balduit, Gabriella Zito, Nicoletta Di Simone, Nicoletta Di Simone, Giuseppe Ricci, Giuseppe Ricci, Taruna Madan, Uday Kishore, Uday Kishore, Roberta Bulla   +14 more
doaj   +2 more sources

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy [PDF]

Frontiers in Cell and Developmental Biology
The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression.
Ruchi Saxena, Elizabeth B. Gottlin, Michael J. Campa, Ryan T. Bushey, Jian Guo, Edward F. Patz, Edward F. Patz, You-Wen He   +7 more
doaj   +2 more sources

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. [PDF]

PLoS Genetics, 2011
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the ...
Jian Zhao, Hui Wu, Melanie Khosravi, Huijuan Cui, Xiaoxia Qian, Jennifer A Kelly, Kenneth M Kaufman, Carl D Langefeld, Adrienne H Williams, Mary E Comeau, Julie T Ziegler, Miranda C Marion, Adam Adler, Stuart B Glenn, Marta E Alarcón-Riquelme, BIOLUPUS Network, GENLES Network, Bernardo A Pons-Estel, John B Harley, Sang-Cheol Bae, So-Young Bang, Soo-Kyung Cho, Chaim O Jacob, Timothy J Vyse, Timothy B Niewold, Patrick M Gaffney, Kathy L Moser, Robert P Kimberly, Jeffrey C Edberg, Elizabeth E Brown, Graciela S Alarcon, Michelle A Petri, Rosalind Ramsey-Goldman, Luis M Vilá, John D Reveille, Judith A James, Gary S Gilkeson, Diane L Kamen, Barry I Freedman, Juan-Manuel Anaya, Joan T Merrill, Lindsey A Criswell, R Hal Scofield, Anne M Stevens, Joel M Guthridge, Deh-Ming Chang, Yeong Wook Song, Ji Ah Park, Eun Young Lee, Susan A Boackle, Jennifer M Grossman, Bevra H Hahn, Timothy H J Goodship, Rita M Cantor, Chack-Yung Yu, Nan Shen, Betty P Tsao   +56 more
doaj   +4 more sources

The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury. [PDF]

Front Med (Lausanne), 2023
Teoh CW, Riedl Khursigara M, Ortiz-Sandoval CG, Park JW, Li J, Bohorquez-Hernandez A, Bruno V, Bowen EE, Freeman SA, Robinson LA, Licht C.   +10 more
europepmc   +3 more sources

Glycoproteomics analysis of complement factor H and its complement-regulatory function during <i>Streptococcus pneumoniae</i>-associated hemolytic uremic syndrome. [PDF]

Front Immunol
Baas LM, Wijnsma KL, Zijlstra F, van de Kar NCAJ, Ter Steeg L, Bouts AHM, Michels MAHM, Langereis JD, Lefeber D, Wessels HJCT, van den Heuvel LP.   +10 more
europepmc   +3 more sources