Results 11 to 20 of about 2,642,556 (405)
Complement factor H and the hemolytic uremic syndrome [PDF]
The Journal of Experimental Medicine, 2007 Immune recognition is coupled to powerful proinflammatory effector pathways that must be tightly regulated. The ancient alternative pathway of complement activation is one such proinflammatory pathway.
Atkinson, John P, Goodship, Timothy H.J.
core +8 more sources
The complement factor H‐related proteins
Immunological Reviews, 2016 SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
N. Medjeral-Thomas, M. Pickering
semanticscholar +5 more sources
Microbes bind complement inhibitor factor H via a common site. [PDF]
PLoS Pathogens, 2013 To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri +9 more
doaj +6 more sources
Myeloperoxidase influences the complement regulatory activity of complement factor H [PDF]
Rheumatology, 2018 The interaction between neutrophils and activation of alternative complement pathway plays a critical role in the pathogenesis of ANCA-associated vasculitis (AAV). MPO, which can be released from ANCA-stimulated neutrophils, was recently demonstrated to be capable of activating the alternative complement pathway.
Su-Fang Chen +5 more
semanticscholar +3 more sources
Complement factor H in host defense and immune evasion [PDF]
Cellular and Molecular Life Sciences, 2016 Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity.
Raffaella Parente +3 more
semanticscholar +5 more sources
Protective role of complement factor H against the development of preeclampsia [PDF]
Frontiers in ImmunologyPregnancy is an immunologically regulated, complex process. A tightly controlled complement system plays a crucial role in the successful establishment of pregnancy and parturition.
Hadida Yasmin +14 more
doaj +2 more sources
Dimerization of complement factor H-related proteins modulates complement activation in vivo [PDF]
Proceedings of the National Academy of Sciences, 2013 The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related ( CFHR ) locus. Elucidating the mechanism underlying these associations has been hindered
E. Goicoechea de Jorge +10 more
semanticscholar +6 more sources
Complement factor H: a novel innate immune checkpoint in cancer immunotherapy [PDF]
Frontiers in Cell and Developmental BiologyThe elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression.
Ruchi Saxena +7 more
doaj +2 more sources
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. [PDF]
PLoS Genetics, 2007 Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Disease-associated mutations have been described in the genes encoding the complement regulators complement factor H, membrane cofactor protein, factor B, and ...
Peter F Zipfel +13 more
doaj +5 more sources