Results 11 to 20 of about 1,227,803 (177)

Editorial: Function and Dysfunction of Complement Factor H [PDF]

Frontiers in Immunology, 2022
Non peer ...
Mihály Józsi, Paul Nigel Barlow, Seppo Meri   +2 more
doaj   +9 more sources

Complement factor H in molecular regulation of angiogenesis [PDF]

Medical Review
Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju   +6 more
doaj   +4 more sources

Hijacking Factor H for Complement Immune Evasion [PDF]

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +3 more sources

Factor H Autoantibodies and Complement-Mediated Diseases [PDF]

Frontiers in Immunology, 2020
Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang, Nicolo Ghiringhelli Borsa, Dingwu Shao, Arthur Dopler, Michael B. Jones, Nicole C. Meyer, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Christoph Q. Schmidt, Richard J. H. Smith   +10 more
doaj   +4 more sources

Microbes bind complement inhibitor factor H via a common site. [PDF]

PLoS Pathogens, 2013
To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri, H Amdahl, M J Lehtinen, S Hyvärinen, J V McDowell, A Bhattacharjee, S Meri, R Marconi, A Goldman, T S Jokiranta   +9 more
doaj   +11 more sources

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]

Frontiers in Immunology, 2020
Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig, Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Lars Fester, Moin A. Saleem, Jun Oh, Jun Oh   +14 more
doaj   +5 more sources

Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser, Munirah eAbdul-Aziz, Munirah eAbdul-Aziz, Annapurna eNayak, Cordula M Stover, Robert B Sim, Robert B Sim, Uday eKishore   +7 more
doaj   +3 more sources

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]

Frontiers in Immunology
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag   +17 more
doaj   +2 more sources

Protective role of complement factor H against the development of preeclampsia [PDF]

Frontiers in Immunology
Pregnancy is an immunologically regulated, complex process. A tightly controlled complement system plays a crucial role in the successful establishment of pregnancy and parturition.
Hadida Yasmin, Chiara Agostinis, Miriam Toffoli, Tamali Roy, Silvia Pegoraro, Andrea Balduit, Gabriella Zito, Nicoletta Di Simone, Nicoletta Di Simone, Giuseppe Ricci, Giuseppe Ricci, Taruna Madan, Uday Kishore, Uday Kishore, Roberta Bulla   +14 more
doaj   +2 more sources

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy [PDF]

Frontiers in Cell and Developmental Biology
The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression.
Ruchi Saxena, Elizabeth B. Gottlin, Michael J. Campa, Ryan T. Bushey, Jian Guo, Edward F. Patz, Edward F. Patz, You-Wen He   +7 more
doaj   +2 more sources