Results 21 to 30 of about 1,227,803 (177)

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. [PDF]

PLoS Genetics, 2011
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the ...
Jian Zhao, Hui Wu, Melanie Khosravi, Huijuan Cui, Xiaoxia Qian, Jennifer A Kelly, Kenneth M Kaufman, Carl D Langefeld, Adrienne H Williams, Mary E Comeau, Julie T Ziegler, Miranda C Marion, Adam Adler, Stuart B Glenn, Marta E Alarcón-Riquelme, BIOLUPUS Network, GENLES Network, Bernardo A Pons-Estel, John B Harley, Sang-Cheol Bae, So-Young Bang, Soo-Kyung Cho, Chaim O Jacob, Timothy J Vyse, Timothy B Niewold, Patrick M Gaffney, Kathy L Moser, Robert P Kimberly, Jeffrey C Edberg, Elizabeth E Brown, Graciela S Alarcon, Michelle A Petri, Rosalind Ramsey-Goldman, Luis M Vilá, John D Reveille, Judith A James, Gary S Gilkeson, Diane L Kamen, Barry I Freedman, Juan-Manuel Anaya, Joan T Merrill, Lindsey A Criswell, R Hal Scofield, Anne M Stevens, Joel M Guthridge, Deh-Ming Chang, Yeong Wook Song, Ji Ah Park, Eun Young Lee, Susan A Boackle, Jennifer M Grossman, Bevra H Hahn, Timothy H J Goodship, Rita M Cantor, Chack-Yung Yu, Nan Shen, Betty P Tsao   +56 more
doaj   +4 more sources

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H., Dierich, Manfred P.   +4 more
openaire   +4 more sources

C3 Glomerulonephritis associated with Anti-complement Factor H Autoantibodies in an Adolescent Male: A Case Report [PDF]

Childhood Kidney Diseases, 2021
C3 glomerulonephritis (C3GN), a rare condition associated with dysregulation of the alternative pathway of the complement system, is histopathologically characterized by isolated or dominant C3 deposition in the renal glomeruli.
HyeSun Hyun, Hee Gyung Kang, UiJu Cho, Il-Soo Ha, Hae Il Cheong   +4 more
doaj   +1 more source

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

Computational and Structural Biotechnology Journal, 2023
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina, Juliana Parsons, Eva L. Decker, Ralf Reski   +3 more
doaj   +1 more source

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
doaj   +1 more source

Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

BMC Immunology, 2021
Background The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. Results 217 patients with renal biopsy-proven active LN were enrolled.
Fengmei Wang, Jirong Yu, Lei Zhang, Yan Zhang, Jie Zhang, Bicheng Liu, Xiaowei Yang   +6 more
doaj   +1 more source

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
A Alitalo, A Alitalo, A Alitalo, A Seling, AC Steere, AM Blom, Andreas Klos, AP van Dam, B Stevenson, C Hammerschmidt, C Siegel, C Siegel, Christine Skerka, Claudia Hammerschmidt, CS Brooks, Dania Richter, E Diza, F Strle, Franz-Rainer Matuschka, H Jiang, H Michel, J Hellwage, J Pietikainen, J Potempa, Jasmin Schwab, JD Lambris, JV McDowell, K Hartmann, K Haupt, K Kurtenbach, K Kurtenbach, K Saito, K Whaley, KM Hovis, KP Hunfeld, L Beinrohr, M Collares-Pereira, M Jusko, M Józsi, MJ Walport, MK Pangburn, MR Bhide, MR Bhide, MR Kenedy, MS Metts, N Marr, ND van Burgel, P Herzberger, P Herzberger, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Ramu, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, R Dieterich, R Wallich, Reinhard Wallich, RG Discipio, RJ Ziccardi, S Breitner-Ruddock, S Grosskinsky, S Grosskinsky, S Heinen, S Kühn, SC Bock, SG Rijpkema, SH Rooijakkers, T Fujita, T Fujita, V Brade, Y Terao   +76 more
core   +9 more sources

Contribución de variantes funcionales y cuantitativas del Factor H y las proteínas FHRs (Factor H-Related proteins) del Complemento en patología renal

Nefrología, 2022
Resumen: El sistema del Complemento protege al organismo frente a procesos infecciosos, tumorales y autoinmunes, y requiere una regulación muy estricta para evitar una activación excesiva o inespecífica.
Irene Gómez Delgado, Pilar Sánchez-Corral   +1 more
doaj   +1 more source

Truncated forms of human complement factor H [PDF]

Biochemical Journal, 1989
By the use of Western-blot analyses with polyclonal anti-(Factor H) antibodies, two low-Mr protein species of Mr 41,000 and 37,000 under non-reducing conditions and 43,000 and 40,000 under reducing conditions are consistently detected together with the well-known 155,000-Mr Factor H in human plasma and serum. These two additional species are also found
Fontaine, M., Demares, M. J., Koistinen, V., Day, A. J., Davrinche, C., Sim, R. B., Ripoche, J.   +6 more
openaire   +3 more sources