Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]
, 1991 The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz +23 more
core +1 more source
Complement factors (H) into thrombosis [PDF]
Blood, 2017 In this issue of Blood, Ueda et al demonstrate that a mutation in factor H (FH) disrupts host cell interactions, leading to dysregulation of complement, systemic thrombotic angiopathy, and hemolytic uremic syndrome ...
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Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells
Frontiers in Immunology, 2021 Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD).
Nicole Schäfer +9 more
doaj +1 more source
The complement factor H‐related proteins
Immunological Reviews, 2016 SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
Medjeral-Thomas, N, Pickering, MC
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Factor H Family Proteins in Complement Evasion of Microorganisms
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
doaj +1 more source
PLoS ONE, 2021 Exosomes are a class of extracellular vesicles (EVs) that are mediators of normal intercellular communication, but exosomes are also used by tumor cells to promote oncogenesis and metastasis.
Ryan T Bushey +3 more
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Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hammerschmidt, Claudia +6 more
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Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children
Frontiers in Immunology, 2018 Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek +10 more
doaj +1 more source
Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy [PDF]
, 2016 Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes.
Dorin-Bogdan Borza
core +5 more sources
Factor H preserves alternative complement function during ARDS, linked to improved survival
ERJ Open Research, 2023 Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain +11 more
doaj +1 more source