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Complementation of Subquandles [PDF]

Involve 18 (2025) 417-435, 2023
Saki and Kiani proved that the subrack lattice of a rack $R$ is necessarily complemented if $R$ is finite but not necessarily complemented if $R$ is infinite. In this paper, we investigate further avenues related to the complementation of subquandles.
arxiv   +1 more source

Components of the Complement Cascade Differ in Polycystic Ovary Syndrome [PDF]

, 2022
Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitory ...
Atkin, Stephen L., Butler, Alexandra E., Moin, Abu Saleh Md, Sathyapalan, Thozhukat   +3 more
core   +1 more source

Tumour extracellular vesicle‐derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement‐dependent cytotoxicity of tumour cells

Journal of Extracellular Vesicles, 2020
The complement system is involved in the immunosurveillance of pathogens and tumour cells. Proteomic profiling revealed that extracellular vesicles (EVs) released by metastatic hepatocellular carcinoma (HCC) cells contained a significant number of ...
X. Mao, Longyin Zhou, S. K. Tey, A. P. Ma, Cherlie Lot Sum Yeung, T. Ng, S. Wong, Bonnie Hei Man Liu, Y. M. E. Fung, E. Patz, P. Cao, Yi Gao, J. Yam   +12 more
semanticscholar   +1 more source

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +1 more source

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Dierich, Manfred P., Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H.   +4 more
core   +1 more source

A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Dysregulation of the alternative complement pathway due to impaired binding of complement factor H (CFH) to self-ligands or altered self-ligands (e.g.
Lejla Alic, N. Papac-Miličević, D. Czamara, Ramona B Rudnick, M. Ozsvár-Kozma, A. Hartmann, Michael Gurbisz, G. Hoermann, Stefanie Haslinger-Hutter, P. Zipfel, C. Skerka, E. Binder, C. Binder   +12 more
semanticscholar   +1 more source

Complement factors (H) into thrombosis [PDF]

Blood, 2017
In this issue of Blood, Ueda et al demonstrate that a mutation in factor H (FH) disrupts host cell interactions, leading to dysregulation of complement, systemic thrombotic angiopathy, and hemolytic uremic syndrome ...
openaire   +3 more sources

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Frontiers in Immunology, 2021
Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD).
Nicole Schäfer, Nicole Schäfer, Anas Rasras, Anas Rasras, Delia M. Ormenisan, Sabine Amslinger, Volker Enzmann, Herbert Jägle, Diana Pauly, Diana Pauly   +9 more
doaj   +1 more source

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children

Frontiers in Immunology, 2018
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek, Anna E. van Beek, Angela Kamp, Simone Kruithof, Ed J. Nieuwenhuys, Diana Wouters, Ilse Jongerius, Theo Rispens, Taco W. Kuijpers, Taco W. Kuijpers, Kyra A. Gelderman   +10 more
doaj   +1 more source