Results 41 to 50 of about 1,492,125 (362)
Complement factor H levels in steady state sickle cell anaemia [PDF]
, 2017 Objective: The red cell membrane of sickle cell anaemia is vulnerable to attack from the alternative complement pathway. The activation of the alternative complement pathway is initiated by externalization of phosphatidylserine on red cell membrane ...
Ajiboye, A.O. +5 more
core +2 more sources
Virulence, 2020 Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we
Yanfei Yu +11 more
doaj +1 more source
Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells [PDF]
, 2009 Intrarenal complement activation plays an important role in the progression of chronic kidney disease. A key target of the activated complement cascade is the proximal tubule, a site where abnormally filtered plasma proteins and complement factors ...
Abbate, Mauro +9 more
core +1 more source
Computational and Structural Biotechnology Journal, 2023 Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina +3 more
doaj
Anesthetic management of living donor liver transplantation for complement factor H deficiency hemolytic uremic syndrome: a case report [PDF]
Korean Journal of Anesthesiology, 2014 We experienced a living donor liver transplantation for a 26-month-old girl with complement factor H deficiency. Complement factor H is a plasma protein that regulates the activity of the complement pathway.
Suk-Hee Park, Gaab-Soo Kim
doaj +1 more source
Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions
Frontiers in Immunology, 2021 Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti +7 more
doaj +1 more source
Frontiers in Microbiology, 2015 The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough
Rauna eRiva +2 more
doaj +1 more source
Interaction of complement factor h and fibulin3 in age-related macular degeneration. [PDF]
PLoS ONE, 2013 Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE).
M Keith Wyatt +7 more
doaj +1 more source
Complement factor H related proteins (CFHRs)
Molecular Immunology, 2013 Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central complement component C3b. Mutations, genetic deletions, duplications or rearrangements in the individual CFHR genes are associated with a number of diseases including atypical hemolytic uremic ...
Véronique Frémeaux-Bacchi +5 more
openaire +3 more sources
Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H [PDF]
Clinical and Experimental Immunology, 2007 SummaryOTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR HStructural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111/j.1365-2249.2007.03553.xTherapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative ...
Rodríguez de Córdoba, Santiago +1 more
openaire +4 more sources