Results 41 to 50 of about 1,227,803 (177)

Factor H complements AMD [PDF]

Science-Business eXchange, 2011
EU and U.S. researchers have revealed what could be the mechanistic underpinnings of the increased risk for age-related macular degeneration in individuals with a common polymorphism in the gene for complement factor H.
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Myeloperoxidase influences the complement regulatory activity of complement factor H [PDF]

Rheumatology, 2018
The interaction between neutrophils and activation of alternative complement pathway plays a critical role in the pathogenesis of ANCA-associated vasculitis (AAV). MPO, which can be released from ANCA-stimulated neutrophils, was recently demonstrated to be capable of activating the alternative complement pathway.
Su-Fang, Chen, Feng-Mei, Wang, Zhi-Ying, Li, Feng, Yu, Min, Chen, Ming-Hui, Zhao   +5 more
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Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]

, 2012
Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
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Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex [PDF]

, 2016
Introduction Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b.
Baerga-Ortiz, Bajzar, Boehme, Bossi, Campbell, Conway, de Córdoba S, Delvaeye, Dragon-Durey, Esmon, Esmon, Esmon, Esparza-Gordillo, Faust, Fuentes-Prior, Gordon, Hakobyan, Hamad, Harris, Heurich, Hindmarsh, Honda, Huntington, Ikeda, Ito, Jokiranta, Kavanagh, Li, Light, Maga, Markiewski, Martinez-Barricarte, Mayer, Meri, Mizuno, Moll, Morgan, Mouksassi, Noris, Owen, Pangburn, Sadler, Sadler, Saito, Salem, Sawada, Schramm, Shental-Bechor, Suzuki, Tateishi, Tortajada, Udagawa, Vincent, Walport, Walport, Wu, Yada, Yamamoto, Zushi   +58 more
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Atypical hemolytic uremic syndrome [PDF]

, 2011
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae
Chantal Loirat, Véronique Frémeaux-Bacchi   +1 more
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Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu)

Virulence, 2020
Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we
Yanfei Yu, Jia Wang, Rui Han, Li Wang, Lei Zhang, Amy Yimin Zhang, Jiuqing Xin, Shaoli Li, Yanhua Zeng, Guoqing Shao, Zhixin Feng, Qiyan Xiong   +11 more
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Complement factor H related proteins (CFHRs)

Molecular Immunology, 2013
Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central complement component C3b. Mutations, genetic deletions, duplications or rearrangements in the individual CFHR genes are associated with a number of diseases including atypical hemolytic uremic ...
Skerka, Christine, Chen, Qian, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T.   +3 more
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Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients [PDF]

, 2017
Objective To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs.
Auce, Pauls, Avbersek, Andreja, Baum, Larry, Becker, Felicitas, Brodie, Martin J., Canadian Pharmacogenomics Network for Drug Safety, Carleton, Bruce C., Cavalleri, Gianpiero L., Cendes, Fernando, Cherny, Stacey, Coppola, Antonietta, Delanty, Norman, Depondt, Chantal, EPIGEN Consortium, EpiPGX Consortium, Francis, Ben, Gudmundsson, Lárus J., Gui, Hongsheng, Heggeli, Kristin, Ingason, Andrés, International League Against Epilepsy Consortium on Complex Epil, Johnson, Michael R., Klein, Karl Martin, Koeleman, Bobby P.C., Krause, Roland, Krenn, Martin, Kunz, Wolfram S., Kwan, Patrick, Kwok, Maxwell, Langley, Sarah R., Lerche, Holger, Leu, Costin, Liao, Wei-ping, Lopes-Cendes, Iscia, Marson, Anthony G., McCormack, Mark, O'Brien, Terence J., Pirmohamed, Munir, Rau, Sarah, Ross, Colin J.D, Sander, Josemir W., Secolin, Rodrigo, Shear, Neil, Sills, Graeme J., Sisodiya, Sanjay M., Speed, Doug, Stefánsson, Kári, Striano, Pasquale, Weckhuysen, Sarah, Wolking, Stefan, Wright, Galen E.B., Yasuda, Clarissa, Zara, Federico, Zhang, Eunice J.   +53 more
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FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]

, 2017
Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia, Cserhalmi, Marcell, Csincsi, Ádám, Józsi, Mihály, Kárpáti, Éva, Prohászka, Zoltán, Szabó, Z., Uzonyi, Barbara   +7 more
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The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H

Frontiers in Microbiology, 2015
The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough
Rauna eRiva, Timo K. Korhonen, Seppo eMeri   +2 more
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