Results 41 to 50 of about 1,235,428 (322)

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Frontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider, Mihály Józsi, Mihály Józsi   +7 more
doaj   +1 more source

Complement factor H and the hemolytic uremic syndrome [PDF]

, 2007
Immune recognition is coupled to powerful proinflammatory effector pathways that must be tightly regulated. The ancient alternative pathway of complement activation is one such proinflammatory pathway.
Atkinson, John P, Goodship, Timothy H.J.
core   +3 more sources

FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]

, 2017
Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia, Cserhalmi, Marcell, Csincsi, Ádám, Józsi, Mihály, Kárpáti, Éva, Prohászka, Zoltán, Szabó, Z., Uzonyi, Barbara   +7 more
core   +1 more source

The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H

Frontiers in Microbiology, 2015
The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough
Rauna eRiva, Timo K. Korhonen, Seppo eMeri   +2 more
doaj   +1 more source

Anesthetic management of living donor liver transplantation for complement factor H deficiency hemolytic uremic syndrome: a case report [PDF]

Korean Journal of Anesthesiology, 2014
We experienced a living donor liver transplantation for a 26-month-old girl with complement factor H deficiency. Complement factor H is a plasma protein that regulates the activity of the complement pathway.
Suk-Hee Park, Gaab-Soo Kim
doaj   +1 more source

Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice [PDF]

Kidney International, 2010
Total deficiency of complement factor H (CFH) is associated with dense deposit disease and atypical hemolytic uremic syndrome. CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this pathway and secondary C3 deficiency.
Fakhouri, Fadi, de Jorge, Elena Goicoechea, Brune, Frédérique, Azam, Philippe, Cook, H. Terence, Pickering, Matthew C.   +5 more
openaire   +2 more sources

Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?

Haseki Tıp Bülteni, 2020
Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan, Mazlum Serdar Akaltun, Mustafa Pehlivan, Savaş Gürsoy, Ayşe Feyda Nursal   +4 more
doaj   +1 more source

Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H [PDF]

Clinical and Experimental Immunology, 2007
SummaryOTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR HStructural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111/j.1365-2249.2007.03553.xTherapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative ...
Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena   +1 more
openaire   +3 more sources

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Frontiers in Immunology, 2018
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma.
Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo   +15 more
doaj   +1 more source

Planar posets have dimension at most linear in their height

, 2017
We prove that every planar poset $P$ of height $h$ has dimension at most $192h + 96$. This improves on previous exponential bounds and is best possible up to a constant factor.
Joret, Gwenaël, Micek, Piotr, Wiechert, Veit   +2 more
core   +1 more source