Results 21 to 30 of about 1,688,140 (295)

Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond

, 2022
: Complement is an elaborate system of innate immunity. Genetic variants and autoantibodies leading to excessive complement activation are implicated in a variety of human diseases. Among them, the hematologic disease paroxysmal nocturnal hemoglobinuria (
Gavriilaki, Eleni, de Latour, Régis Peffault, Risitano, Antonio Maria, Antonio Maria Risitano, Régis Peffault de Latour, Eleni Gavriilaki   +5 more
core   +1 more source

The Landscape of IgA Nephropathy Treatment Strategy: A Pharmacological Overview

Future Pharmacology, 2023
IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis and is one of the most common causes of end-stage kidney disease (ESKD) worldwide. The immunopathogenic mechanism underlying IgAN is poorly identified.
Vincenzo Di Leo, Francesca Annese, Federica Papadia, Iris Cara, Marica Giliberti, Fabio Sallustio, Loreto Gesualdo   +6 more
doaj   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
core   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Peters, DK, P J Lachmann, D K Peters, P W Mathieson, Oliveira, DBG, R Würzner, D B Oliveria, Mathieson, PW, Würzner, R, Oliveria, DB   +10 more
core   +1 more source

In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model

Frontiers in Immunology, 2023
Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic capacity and can potentially lead ...
Alexandra Gerogianni, Alexandra Gerogianni, Melissa Bal, Melissa Bal, Camilla Mohlin, Camilla Mohlin, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Dick J. Sjöström, Dick J. Sjöström, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson   +15 more
doaj   +1 more source

Ischemia/reperfusion injury: effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition. [PDF]

, 2014
Ischemia/reperfusion injury (IRI) may occur from ischemia due to thrombotic occlusion, trauma or surgical interventions, including transplantation, with subsequent reestablishment of circulation.
Claudia Duehrkop, Robert Rieben, Rieben, Robert, Dührkop-Sisewitsch, Claudia, Rieben R, Duehrkop C   +5 more
core   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch, Kraiczy Peter, Böhm Sascha, van den Elsen Jean, Koch Tina K., Skerka Christine, Reuter Michael, Zipfel Peter F., Barthel Diana   +25 more
core   +1 more source

No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

Vascular Biology, 2022
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture.
Stijntje Hibender, Siyu Li, Alex V Postma, Myrthe E Hoogeland, Denise Klaver, Richard B Pouw, Hans W Niessen, Antoine HG Driessen, David R Koolbergen, Carlie JM de Vries, Marieke JH Baars, Arjan C Houweling, Paul A Krijnen, Vivian de Waard   +13 more
doaj   +1 more source

Complement Inhibition in Seropositive Generalized Myasthenia Gravis as Rescue Therapy in Impending and Effective Treatment in Frequently Recurring Impending Myasthenic Crisis—A Case Series [PDF]

Therapeutic Advances in Neurological Disorders
Antonios Bayas, Markus Naumann
exaly   +2 more sources

Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice [PDF]

, 2010
The motor axonal variant of Guillain-Barré syndrome is associated with anti-GD1a immunoglobulin antibodies, which are believed to be the pathogenic factor. In previous studies we have demonstrated the motor terminal to be a vulnerable site.
Halstead, S., Furukawa, K., Humphreys, P.D, Willison, H.J., McGonigal, R., Rowan, E.G., Greenshields, K.N, Rother, R.P   +7 more
core   +1 more source