Results 11 to 20 of about 228,991 (253)

Compstatins: the dawn of clinical C3-targeted complement inhibition [PDF]

Trends in Pharmacological Sciences, 2022
Christina Lamers, Dimitrios C Mastellos, Daniel Ricklin   +2 more
exaly   +2 more sources

Complement inhibition prevents glial nodal membrane injury in a GM1 antibody-mediated mouse model [PDF]

Brain Communications, 2022
Rhona Mcgonigal, Jennifer A Barrie, Madeleine E Cunningham   +2 more
exaly   +2 more sources

Alternative Complement Pathway Inhibition by Lampalizumab

Ophthalmology Science, 2023
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS, Verena Steffen, MSc, Lee A. Honigberg, PhD, Michael C. Chang, PhD   +3 more
doaj   +1 more source

Complement inhibition in cancer therapy [PDF]

Seminars in Immunology, 2013
For decades, complement has been recognized as an effector arm of the immune system that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have been proposed that are based on the intensification of complement-mediated responses against tumors.
Ruben, Pio, Daniel, Ajona, John D, Lambris   +2 more
openaire   +2 more sources

Activation of the complement system by nanoparticles and strategies for complement inhibition

European Journal of Pharmaceutics and Biopharmaceutics, 2023
The complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including crosstalk with the adaptive immune system, the contact (coagulation) and the kinin systems, and alarmin high-mobility group ...
Hajira B, Haroon, Elisha, Dhillon, Z Shadi, Farhangrazi, Panagiotis N, Trohopoulos, Dmitri, Simberg, S Moein, Moghimi   +5 more
openaire   +2 more sources

Complement inhibition in seropositive generalized myasthenia gravis as rescue therapy in impending and effective treatment in frequently recurring impending myasthenic crisis—a case series [PDF]

Therapeutic Advances in Neurological Disorders
Markus Naumann, Antonios Bayas
exaly   +2 more sources

Enhancement of Hemagglutination Inhibition by Complement [PDF]

Infection and Immunity, 1972
Experiments were conducted to determine the effect of specific antibody and complement on hemagglutination inhibition of influenza virus. It was found that early immunoglobulin M antibody to influenza virus inhibited the hemagglutinating capacity of the virus. When fresh guinea pig serum was added, the inhibiting capacity of the serum was elevated from
P W, Reno, E M, Hoffmann
openaire   +2 more sources

In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries

Frontiers in Immunology, 2021
IntroductionDonor brain death (BD) is an unavoidable component of vascularized composite allograft (VCA) transplantation and a key contributor to ischemia-reperfusion injury (IRI).
Biao Lei, M. Mahdi Sleiman, Qi Cheng, Qi Cheng, Zhenxiao Tu, Zhenxiao Tu, Peng Zhu, Peng Zhu, Martin Goddard, Paulo N. Martins, Logan Langerude, Satish Nadig, Satish Nadig, Stephen Tomlinson, Stephen Tomlinson, Stephen Tomlinson, Carl Atkinson, Carl Atkinson, Carl Atkinson   +18 more
doaj   +1 more source

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

Frontiers in Immunology, 2018
Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
Sidonia Mihai, Sidonia Mihai, Misa Hirose, Yi Wang, Joshua M. Thurman, V. Michael Holers, B. Paul Morgan, Jörg Köhl, Jörg Köhl, Detlef Zillikens, Ralf J. Ludwig, Falk Nimmerjahn   +11 more
doaj   +1 more source

CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Frontiers in Immunology, 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt   +11 more
doaj   +1 more source