Results 11 to 20 of about 1,688,140 (295)

Complement inhibition in ANCA vasculitis

Néphrologie & Thérapeutique, 2019
A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed.
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Complement Activation and Inhibition in Wound Healing [PDF]

Clinical and Developmental Immunology, 2012
Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore,
Gwendolyn Cazander, Gerrolt N. Jukema, Peter H. Nibbering   +2 more
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Aliskiren and the dual complement inhibition concept [PDF]

Clinical Kidney Journal, 2019
Abstract In this issue of Clinical Kidney Journal, Plasse et al. report on the use of high-dose aliskiren as an adjunct therapy in a patient treated with eculizumab for haemolytic uraemic syndrome (HUS). This follows the recent description of the complement factor 3 (C3) activating activity of the enzyme renin and the successful ...
Perez-Gomez, Maria Vanessa, Ortiz, Alberto   +1 more
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Complement inhibition in cancer therapy [PDF]

Seminars in Immunology, 2013
For decades, complement has been recognized as an effector arm of the immune system that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have been proposed that are based on the intensification of complement-mediated responses against tumors.
Ruben, Pio, Daniel, Ajona, John D, Lambris   +2 more
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Activation of the complement system by nanoparticles and strategies for complement inhibition

European Journal of Pharmaceutics and Biopharmaceutics, 2023
The complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including crosstalk with the adaptive immune system, the contact (coagulation) and the kinin systems, and alarmin high-mobility group ...
Hajira B, Haroon, Elisha, Dhillon, Z Shadi, Farhangrazi, Panagiotis N, Trohopoulos, Dmitri, Simberg, S Moein, Moghimi   +5 more
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A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
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In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries

Frontiers in Immunology, 2021
IntroductionDonor brain death (BD) is an unavoidable component of vascularized composite allograft (VCA) transplantation and a key contributor to ischemia-reperfusion injury (IRI).
Biao Lei, M. Mahdi Sleiman, Qi Cheng, Qi Cheng, Zhenxiao Tu, Zhenxiao Tu, Peng Zhu, Peng Zhu, Martin Goddard, Paulo N. Martins, Logan Langerude, Satish Nadig, Satish Nadig, Stephen Tomlinson, Stephen Tomlinson, Stephen Tomlinson, Carl Atkinson, Carl Atkinson, Carl Atkinson   +18 more
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Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway

Frontiers in Microbiology, 2017
The complement system is a crucial defensive network that protects the host against invading pathogens. It is part of the innate immune system and can be initiated via three pathways: the lectin, classical and alternative activation pathway.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Peter Garred   +3 more
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Enhancement of Hemagglutination Inhibition by Complement [PDF]

Infection and Immunity, 1972
Experiments were conducted to determine the effect of specific antibody and complement on hemagglutination inhibition of influenza virus. It was found that early immunoglobulin M antibody to influenza virus inhibited the hemagglutinating capacity of the virus. When fresh guinea pig serum was added, the inhibiting capacity of the serum was elevated from
P W, Reno, E M, Hoffmann
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CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Frontiers in Immunology, 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Johannes Zeller, Balázs Bogner, Jurij Kiefer, David Braig, David Braig, Oscar Winninger, Mark Fricke, Ebru Karasu, Karlheinz Peter, Karlheinz Peter, Markus Huber-Lang, Steffen Ulrich Eisenhardt   +11 more
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