Results 11 to 20 of about 1,596,091 (292)
Complement inhibition in ANCA vasculitis
Néphrologie & Thérapeutique, 2019 A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed.
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Pharmacologic Complement Inhibition in Clinical Transplantation
Current Transplantation Reports, 2017 Abstract Purpose of Review Over the past two decades, significant strides made in our understanding of the etiology of antibody-mediated rejection (AMR) in transplantation have put the complement system in the spotlight.
Tatapudi, Vasishta S. +1 more
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Compstatins: the dawn of clinical C3-targeted complement inhibition [PDF]
Trends in Pharmacological Sciences, 2022 Daniel Ricklin +2 more
exaly +2 more sources
Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels [PDF]
Frontiers in Immunology, 2023 Daniel Ricklin +2 more
exaly +2 more sources
Alternative Complement Pathway Inhibition by Lampalizumab
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
doaj +1 more source
Complement inhibition in cancer therapy [PDF]
Seminars in Immunology, 2013 For decades, complement has been recognized as an effector arm of the immune system that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have been proposed that are based on the intensification of complement-mediated responses against tumors.
Ruben, Pio +2 more
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The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
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Activation of the complement system by nanoparticles and strategies for complement inhibition
European Journal of Pharmaceutics and Biopharmaceutics, 2023 The complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including crosstalk with the adaptive immune system, the contact (coagulation) and the kinin systems, and alarmin high-mobility group ...
Hajira B, Haroon +5 more
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A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]
, 2010 Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P. +20 more
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Frontiers in Immunology, 2021 IntroductionDonor brain death (BD) is an unavoidable component of vascularized composite allograft (VCA) transplantation and a key contributor to ischemia-reperfusion injury (IRI).
Biao Lei +18 more
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