Results 31 to 40 of about 228,991 (253)
Complement in Sickle Cell Disease: Are We Ready for Prime Time?
Journal of Blood Medicine, 2021 Christos Varelas,1 Athina Tampaki,2 Ioanna Sakellari,1 &Agr;chilles Anagnostopoulos,1 Eleni Gavriilaki,1,* Efthymia Vlachaki2,* 1Hematology Department – BMT Unit, G.
Varelas C +5 more
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IgA Nephropathy: Current Treatment and New Insights
Antibodies, 2023 IgA Nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. Despite the histopathologic hallmark of mesangial IgA deposition, IgAN is a heterogenous autoimmune disease not only in terms of clinical presentation but also in ...
Dimitra Petrou +3 more
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Frontiers in MedicineBackgroundHematopoietic stem cell transplantation (HSCT) offers a potential cure for various hematologic malignancies and non-malignant disorders but is often accompanied by severe complications, one of the most challenging being transplant-associated ...
Tatiana A. Rudakova +11 more
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Frontiers in NeurologyBackgroundEculizumab, a humanized monoclonal antibody targeting the C5 complement protein, has been approved for the treatment of neuromyelitis optica spectrum disorders (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive (Ab ...
Romain Marignier +7 more
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PlateletsPlatelet storage is associated with storage lesions, including platelet morphological changes and a gradual functional loss. We investigated the impact of complement C3 inhibition on complement activation and platelet storage lesions in clinical platelet
Linnea I. Andersson +7 more
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Complement inhibition in ANCA vasculitis
Néphrologie & Thérapeutique, 2019 A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed.
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The role of complement inhibition in kidney transplantation [PDF]
British Medical Bulletin, 2017 The complement system which belongs to the innate immune system acts both as a first line of defence against various pathogens and as a guardian of host homeostasis. The role of complement has been recently highlighted in several aspects of kidney transplantation: ischaemia-reperfusion, antibody-mediated rejection and native kidney disease recurrence ...
C, Legendre +3 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
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Inhibition of complement activation in cardiac surgery [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2006 DOI:€10.1016/j.jtcvs.2005.10.019 J Thorac Cardiovasc Surg 2006;131:266-267 Frank W. Sellke and Munir Boodhwani Inhibition of complement activation in cardiac surgery http://jtcs.ctsnetjournals.org/cgi/content/full/131/2/266 located on the World Wide Web at: The online version of this article, along with updated information and services ...
Sellke, Frank W., Boodhwani, Munir
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta +6 more
wiley +1 more source