Results 31 to 40 of about 1,596,091 (292)

Ischemia/reperfusion injury: effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition. [PDF]

, 2014
Ischemia/reperfusion injury (IRI) may occur from ischemia due to thrombotic occlusion, trauma or surgical interventions, including transplantation, with subsequent reestablishment of circulation.
Claudia Duehrkop, Robert Rieben, Rieben, Robert, Dührkop-Sisewitsch, Claudia   +3 more
core   +1 more source

No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

Vascular Biology, 2022
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture.
Stijntje Hibender, Siyu Li, Alex V Postma, Myrthe E Hoogeland, Denise Klaver, Richard B Pouw, Hans W Niessen, Antoine HG Driessen, David R Koolbergen, Carlie JM de Vries, Marieke JH Baars, Arjan C Houweling, Paul A Krijnen, Vivian de Waard   +13 more
doaj   +1 more source

Optic neuritis in CD59 deficiency: an extremely rare presentation

The Turkish Journal of Pediatrics, 2022
Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency.
Çağatay Günay, Elvan Yardım, Elif Yaşar, Ayse Semra Hız-Kurul, Gamze Sarıkaya Uzan, Taylan Öztürk, Aylin Yaman, Uluç Yiş   +7 more
doaj   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E, Eridan Rocha-Ferreira, Eridan eRocha-Ferreira, Mariya eHristova, Hristova, M, Mariya Hristova   +5 more
core   +1 more source

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Frontiers in Immunology, 2018
The complement system is an efficient anti-microbial effector mechanism. On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases.
Laure Yatime, Nicolas S. Merle, Annette G. Hansen, Niels Anton Friis, Niels Anton Friis, Jakob A. Østergaard, Mette Bjerre, Lubka T. Roumenina, Steffen Thiel, Peter Kristensen, Gregers R. Andersen   +10 more
doaj   +1 more source

Carbohydrate recognition and complement activation by rat ficolin-B [PDF]

, 2010
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells. Humans produce two serum forms (L-and H-ficolin) and a leukocyte-associated form (M-ficolin), whereas rodents and most other mammals produce ficolins-A and -B ...
Roscher, Silke, Umakhanth Venkatraman Girija, Russell Wallis, Mitchell, Daniel A., Girija, Umakhanth Venkatraman, Wallis, Russell, Wallis, R., Mitchell, D. A., Venkatraman Girija, U., Roscher, S., Daniel A. Mitchell, Silke Roscher   +11 more
core   +1 more source

Complement-targeted therapies for transplant-associated thrombotic microangiopathy: recent advances

Frontiers in Pharmacology
Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of hematopoietic stem cell transplantation in which systemic complement activation induces endothelial injury, leading to microangiopathic hemolytic anemia ...
Taichiro Tokura, Taichiro Tokura, Sayuri Motomura   +2 more
doaj   +1 more source

Complement in Sickle Cell Disease: Are We Ready for Prime Time?

Journal of Blood Medicine, 2021
Christos Varelas,1 Athina Tampaki,2 Ioanna Sakellari,1 &Agr;chilles Anagnostopoulos,1 Eleni Gavriilaki,1,* Efthymia Vlachaki2,* 1Hematology Department – BMT Unit, G.
Varelas C, Tampaki A, Sakellari I, Anagnostopoulos A, Gavriilaki E, Vlachaki E   +5 more
doaj  

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells

Cells, 2023
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus ...
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner   +6 more
doaj   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source