Results 31 to 40 of about 1,688,140 (295)

Complement-targeted therapies for transplant-associated thrombotic microangiopathy: recent advances

Frontiers in Pharmacology
Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of hematopoietic stem cell transplantation in which systemic complement activation induces endothelial injury, leading to microangiopathic hemolytic anemia ...
Taichiro Tokura, Taichiro Tokura, Sayuri Motomura   +2 more
doaj   +1 more source

Optic neuritis in CD59 deficiency: an extremely rare presentation

The Turkish Journal of Pediatrics, 2022
Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency.
Çağatay Günay, Elvan Yardım, Elif Yaşar, Ayse Semra Hız-Kurul, Gamze Sarıkaya Uzan, Taylan Öztürk, Aylin Yaman, Uluç Yiş   +7 more
doaj   +1 more source

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Frontiers in Immunology, 2018
The complement system is an efficient anti-microbial effector mechanism. On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases.
Laure Yatime, Nicolas S. Merle, Annette G. Hansen, Niels Anton Friis, Niels Anton Friis, Jakob A. Østergaard, Mette Bjerre, Lubka T. Roumenina, Steffen Thiel, Peter Kristensen, Gregers R. Andersen   +10 more
doaj   +1 more source

Complement in Sickle Cell Disease: Are We Ready for Prime Time?

Journal of Blood Medicine, 2021
Christos Varelas,1 Athina Tampaki,2 Ioanna Sakellari,1 &Agr;chilles Anagnostopoulos,1 Eleni Gavriilaki,1,* Efthymia Vlachaki2,* 1Hematology Department – BMT Unit, G.
Varelas C, Tampaki A, Sakellari I, Anagnostopoulos A, Gavriilaki E, Vlachaki E   +5 more
doaj  

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells

Cells, 2023
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus ...
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner   +6 more
doaj   +1 more source

Complement Activation and Inhibition in Retinal Diseases [PDF]

, 2010
Within the past several decades, a brigade of dedicated researchers from around the world has provided essential insights into the critical niche of immune-mediated inflammation in the pathogenesis of age-related macular degeneration (AMD). Yet, the question has lingered as to whether disease-initiating events are more or less dependent on isolated ...
Mark E, Kleinman, Jayakrishna, Ambati
openaire   +2 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426), Richter Dania, Kraiczy Peter, Schwab Jasmin, Skerka Christine, Hammerschmidt Claudia, Zipfel Peter F., Matuschka Franz-Rainer, Wallich Reinhard   +32 more
core   +1 more source

Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation

Frontiers in Medicine
BackgroundHematopoietic stem cell transplantation (HSCT) offers a potential cure for various hematologic malignancies and non-malignant disorders but is often accompanied by severe complications, one of the most challenging being transplant-associated ...
Tatiana A. Rudakova, Julia Yu Vlasova, Olesya V. Paina, Olga A. Slesarchuk, Marina A. Gorodnova, Tatiana S. Schegoleva, Oleg V. Goloshchapov, Tatiana A. Bykova, Elena V. Morozova, Lyudmila S. Zubarovskaya, Ivan S. Moiseev, Alexander D. Kulagin   +11 more
doaj   +1 more source

Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. [PDF]

PLoS ONE, 2014
Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulting ...
Lukmanee Tradtrantip, Nithi Asavapanumas, Puay-Wah Phuan, A S Verkman   +3 more
doaj   +1 more source

Real-life study to assess effectiveness and safety of eculizumab in patients with neuromyelitis optica spectrum disorders in France: protocol for ECUP4, an observational study

Frontiers in Neurology
BackgroundEculizumab, a humanized monoclonal antibody targeting the C5 complement protein, has been approved for the treatment of neuromyelitis optica spectrum disorders (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive (Ab ...
Romain Marignier, David Laplaud, Hélène Zéphir, Caroline Papeix, Emmanuelle Leray, Ekbel Amri, Mickaël Piotaix, Jérôme de Sèze   +7 more
doaj   +1 more source