Results 41 to 50 of about 1,596,091 (292)

Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model. [PDF]

PLoS ONE, 2014
Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulting ...
Lukmanee Tradtrantip, Nithi Asavapanumas, Puay-Wah Phuan, A S Verkman   +3 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

Complement Activation and Inhibition in Retinal Diseases [PDF]

, 2010
Within the past several decades, a brigade of dedicated researchers from around the world has provided essential insights into the critical niche of immune-mediated inflammation in the pathogenesis of age-related macular degeneration (AMD). Yet, the question has lingered as to whether disease-initiating events are more or less dependent on isolated ...
Mark E, Kleinman, Jayakrishna, Ambati
openaire   +2 more sources

Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation

Frontiers in Medicine
BackgroundHematopoietic stem cell transplantation (HSCT) offers a potential cure for various hematologic malignancies and non-malignant disorders but is often accompanied by severe complications, one of the most challenging being transplant-associated ...
Tatiana A. Rudakova, Julia Yu Vlasova, Olesya V. Paina, Olga A. Slesarchuk, Marina A. Gorodnova, Tatiana S. Schegoleva, Oleg V. Goloshchapov, Tatiana A. Bykova, Elena V. Morozova, Lyudmila S. Zubarovskaya, Ivan S. Moiseev, Alexander D. Kulagin   +11 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

Real-life study to assess effectiveness and safety of eculizumab in patients with neuromyelitis optica spectrum disorders in France: protocol for ECUP4, an observational study

Frontiers in Neurology
BackgroundEculizumab, a humanized monoclonal antibody targeting the C5 complement protein, has been approved for the treatment of neuromyelitis optica spectrum disorders (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive (Ab ...
Romain Marignier, David Laplaud, Hélène Zéphir, Caroline Papeix, Emmanuelle Leray, Ekbel Amri, Mickaël Piotaix, Jérôme de Sèze   +7 more
doaj   +1 more source

IgA Nephropathy: Current Treatment and New Insights

Antibodies, 2023
IgA Nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. Despite the histopathologic hallmark of mesangial IgA deposition, IgAN is a heterogenous autoimmune disease not only in terms of clinical presentation but also in ...
Dimitra Petrou, Petros Kalogeropoulos, George Liapis, Sophia Lionaki   +3 more
doaj   +1 more source

Inhibition of monocyte complement receptor enhancement by low molecular weight material from human lung cancers [PDF]

, 1981
We have studied the effect of dialysates from lung cancer homogenates to alter both the expression of complement (C3b) receptors per se and also to inhibit leucoattractant-induced enhancement of complement rosettes on monocytes from healthy individuals ...
Kay, A B, Abell, C A, Glass, E J
core  

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source