Results 31 to 40 of about 125,164 (165)
PLoS Pathogens, 2019 Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 ...
Zoltán Attila Nagy +10 more
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Immune Adherence by the Alternate Complement Pathway
Experimental Biology and Medicine, 1972 SummaryThe ability of the alternate complement pathway to generate the immune adherence reaction was studied in C4D guinea pig sera. It was found that IA via the alternate pathway could be generated by endotoxins and immune complexes, but that this phenomenon could not be produced by optimally sensitized intact mammalian cell membranes.
J E, May, M A, Kane, M M, Frank
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Autoantibodies against alternative complement pathway proteins in renal pathologies
Nefrología (English Edition), 2016 Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
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PharmaceuticalsThe alternative pathway of the complement system is implicated in the etiology of age-related macular degeneration (AMD). Complement depletion with pegcetacoplan and avacincaptad pegol are FDA-approved treatments for geographic atrophy in AMD that, while
Sheri L. Peterson +10 more
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PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
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Looking back on the alternative complement pathway [PDF]
Immunobiology, 2018 The alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge.
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Deficient Alternative Complement Pathway Activity in Newborn Sera [PDF]
Pediatric Research, 1979 Neonatal susceptibility to overwhelming bacterial infection is commonly attributed to a relative deficiency in serum opsonic activity. However, few studies have compared the functional capacity of the classical complement pathway with that of the alternative complement pathway in the neonate.
E L, Mills, B, Björksteń, P G, Quie
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Blockade of Alternative Complement Pathway in Dense Deposit Disease
Case Reports in Nephrology, 2014 A patient aged 17 with dense deposit disease associated with complement activation, circulating C3 Nef, and Factor H mutation presented with nephrotic syndrome and hypertension.
Aurore Berthe-Aucejo +6 more
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Haematologica, 2017 Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan +8 more
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Complement-Amplifying Conditions in Atypical Hemolytic Uremic Syndrome: A Canadian Case Series
Canadian Journal of Kidney Health and Disease, 2022 Rationale: Thrombotic microangiopathies (TMAs) are systemic disorders that often affect the kidneys and encompass a heterogeneous group of conditions, including atypical hemolytic uremic syndrome (aHUS).
Christopher J. Patriquin +4 more
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