Results 31 to 40 of about 330,196 (324)

Mathematical Modelling of Alternative Pathway of Complement System [PDF]

Bulletin of Mathematical Biology, 2020
AbstractThe complement system (CS) is an integral part of innate immunity and can be activated via three different pathways. The alternative pathway (AP) has a central role in the function of the CS. The AP of complement system is implicated in several human disease pathologies.
Suruchi Bakshi, Fraser Cunningham, Eva-Maria Nichols, Marta Biedzka-Sarek, Jessica Neisen, Sebastien Petit-Frere, Christina Bessant, Loveleena Bansal, Lambertus A. Peletier, Stefano Zamuner, Piet H. van der Graaf   +10 more
openaire   +2 more sources

Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome [PDF]

, 2016
Background: The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system ...
Bakker, J.A. (Jaap), Bouts, A.H. (Antonia), Dorresteijn, E.M. (Eiske), Goertz, J. (Joop), Gracchi, V. (Valentina), Heuvel, L.P. (Lambert) van den, Jeronimus-Klaasen, A. (Annelies), Kar, N.C. (Nicole) van de, Keijzer-Veen, M.G. (Mandy), Roos, A. (Anja), van der Molen, R.G. (Renate G.), van der Velden, T.J.A.M. (Thea J. A. M.), van Wijk, J.A.E. (Joanna A. E.), Volokhina, E.B. (Elena), Westra, D.F.   +14 more
core   +9 more sources

Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]

Kidney Research and Clinical Practice, 2023
Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu, Eunji Baek, Hyung-Eun Son, Ji-Young Ryu, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Dong-Wan Chae, Seong Pyo Kim, Su Hwan Kim, Jong Hyun Jhee, Tae Ik Chang, Bum Soon Choi, Ho Jun Chin,   +14 more
doaj   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]

, 2015
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K., Fraser, Robert J., Gunn, Bronwyn M., Heise, Mark T., Herrero, Lara J., Hueston, Linda, Mahalingam, Suresh, Morrison, Thomas E., Ramirez, Ruben, Smith, Paul N., Whitmore, Alan C.   +10 more
core   +1 more source

Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway [PDF]

The Journal of Experimental Medicine, 2001
We studied complement 1 inhibitor (C1-INH) as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, of paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes in human serum. It inhibited the binding of both factors B and C3 to PNH and rabbit erythrocytes and blocked the ability of ...
Eric J. Wagner, Michael M. Frank, Haixiang Jiang, Huamei Zhang   +3 more
openaire   +3 more sources

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

Frontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy, Ismet eBoral, Alan eBevington   +2 more
doaj   +1 more source

Properdin: initiation of alternative complement pathway. [PDF]

Proceedings of the National Academy of Sciences, 1975
Activation of the classical complement (C) system involves conversion of C1 to its active state with subsequent cleavage of C4 and -d C2 so as to form the classical C3 convertase, C42 (a bar indicates the activated form of a protein), which sequentially cleaves C3 and C5 to initiate the cytolytic event associated with the complete reaction.
K F Austen, Douglas T. Fearon
openaire   +2 more sources

Thrombotic microangiopathy mediates poor prognosis among lupus nephritis via complement lectin and alternative pathway activation

Frontiers in Immunology, 2022
ObjectiveThe pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate
Binshan Zhang, Guolan Xing
doaj   +1 more source

Alternative complement pathway deregulation is correlated with dengue severity. [PDF]

PLoS ONE, 2009
BACKGROUND:The complement system, a key component that links the innate and adaptive immune responses, has three pathways: the classical, lectin, and alternative pathways. In the present study, we have analyzed the levels of various complement components
Eduardo J M Nascimento, Ana M Silva, Marli T Cordeiro, Carlos A Brito, Laura H V G Gil, Ulisses Braga-Neto, Ernesto T A Marques   +6 more
doaj   +1 more source

Complement factor H and the hemolytic uremic syndrome [PDF]

, 2007
Immune recognition is coupled to powerful proinflammatory effector pathways that must be tightly regulated. The ancient alternative pathway of complement activation is one such proinflammatory pathway.
Atkinson, John P, Goodship, Timothy H.J.
core   +3 more sources