Results 41 to 50 of about 330,196 (324)

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +1 more source

Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]

, 2012
Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core   +1 more source

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

Frontiers in Immunology, 2021
ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these ...
Margrethe Flesvig Holt, Margrethe Flesvig Holt, Annika E. Michelsen, Annika E. Michelsen, Negar Shahini, Elisabeth Bjørkelund, Christina Holt Bendz, Richard J. Massey, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Bente Halvorsen, Kaspar Broch, Kaspar Broch, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Per H. Nilsson, Per H. Nilsson, Pål Aukrust, Pål Aukrust, Pål Aukrust, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Mieke C. Louwe   +29 more
doaj   +1 more source

Blood protein adsorption onto chitosan [PDF]

, 2002
Chitosan was recently indicated to enhance osteogenesis, improve wound healing but to activate the coagulation and the complement systems. In the present study approximately 10nm thick chitosan film were prepared on aminopropyltriethoxysilane (APTES ...
Benesch, Johan, Tengvall, P.
core   +1 more source

The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy

Frontiers in Immunology, 2019
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V. Rizk, Nicolas Maillard, Bruce A. Julian, Barbora Knoppova, Barbora Knoppova, Todd J. Green, Jan Novak, Robert J. Wyatt   +7 more
doaj   +1 more source

AMD and the alternative complement pathway: genetics and functional implications

Human Genomics, 2016
Age-related macular degeneration (AMD) is an ocular neurodegenerative disorder and is the leading cause of legal blindness in Western societies, with a prevalence of up to 8 % over the age of 60, which continues to increase with age. AMD is characterized
P. L. Tan, Catherine Bowes Rickman, N. Katsanis   +2 more
semanticscholar   +1 more source

A Systematic Investigation on Complement Pathway Activation in Diabetic Retinopathy

Frontiers in Immunology, 2020
The complement system plays a crucial role in retinal homeostasis. While the proteomic analysis of ocular tissues in diabetic retinopathy (DR) has shown the deposition of complement proteins, their exact role in the pathogenesis of DR is yet unclear.
Shahna Shahulhameed, Sushma Vishwakarma, J. Chhablani, Mudit Tyagi, R. Pappuru, Saumya Jakati, S. Chakrabarti, I. Kaur   +7 more
semanticscholar   +1 more source

Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. [PDF]

, 2019
IntroductionLevels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild cognitive impairment (MCI).MethodsParticipants (n = 20 per group) had either MCI ...
Elahi, Fanny M, Goetzl, Edward J, Rissman, Robert A, Schwartz, Janice B, Winston, Charisse N   +4 more
core   +2 more sources

Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

Arthritis Research & Therapy, 2017
BackgroundIn this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV ...
Di Miao, Dan Li, Min Chen, Ming-Hui Zhao
semanticscholar   +1 more source

Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice. [PDF]

PLoS ONE, 2016
Streptococcus pneumoniae is a common cause of sepsis. Effective complement activation is an important component of host defence against invading pathogens, whilst excessive complement activation has been associated with endothelial dysfunction and organ ...
Erika van der Maten, Saskia van Selm, Jeroen D Langereis, Hester J Bootsma, Fred J H van Opzeeland, Ronald de Groot, Marien I de Jonge, Michiel van der Flier   +7 more
doaj   +1 more source