Results 51 to 60 of about 471,706 (342)

AMD and the alternative complement pathway: genetics and functional implications

Human Genomics, 2016
Age-related macular degeneration (AMD) is an ocular neurodegenerative disorder and is the leading cause of legal blindness in Western societies, with a prevalence of up to 8 % over the age of 60, which continues to increase with age. AMD is characterized
P. L. Tan, Catherine Bowes Rickman, N. Katsanis   +2 more
semanticscholar   +1 more source

Immune Adherence by the Alternate Complement Pathway

Experimental Biology and Medicine, 1972
SummaryThe ability of the alternate complement pathway to generate the immune adherence reaction was studied in C4D guinea pig sera. It was found that IA via the alternate pathway could be generated by endotoxins and immune complexes, but that this phenomenon could not be produced by optimally sensitized intact mammalian cell membranes.
Joseph E. May, Michael A. Kane, Michael M. Frank   +2 more
openaire   +3 more sources

Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

Arthritis Research & Therapy, 2017
BackgroundIn this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV ...
Di Miao, Dan Li, Min Chen, Ming-Hui Zhao
semanticscholar   +1 more source

The alternative complement pathway is dysregulated in patients with chronic heart failure

Scientific Reports, 2017
The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement ...
Negar Shahini, A. Michelsen, P. Nilsson, K. Ekholt, L. Gullestad, K. Broch, C. Dahl, P. Aukrust, T. Ueland, T. Mollnes, A. Yndestad, M. C. Louwe   +11 more
semanticscholar   +1 more source

A Systematic Investigation on Complement Pathway Activation in Diabetic Retinopathy

Frontiers in Immunology, 2020
The complement system plays a crucial role in retinal homeostasis. While the proteomic analysis of ocular tissues in diabetic retinopathy (DR) has shown the deposition of complement proteins, their exact role in the pathogenesis of DR is yet unclear.
Shahna Shahulhameed, Sushma Vishwakarma, J. Chhablani, Mudit Tyagi, R. Pappuru, Saumya Jakati, S. Chakrabarti, I. Kaur   +7 more
semanticscholar   +1 more source

Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice. [PDF]

PLoS ONE, 2016
Streptococcus pneumoniae is a common cause of sepsis. Effective complement activation is an important component of host defence against invading pathogens, whilst excessive complement activation has been associated with endothelial dysfunction and organ ...
Erika van der Maten, Saskia van Selm, Jeroen D Langereis, Hester J Bootsma, Fred J H van Opzeeland, Ronald de Groot, Marien I de Jonge, Michiel van der Flier   +7 more
doaj   +1 more source

Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies

Current Issues in Molecular Biology, 2023
Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels are tightly regulated by networks of heme-binding proteins (HeBPs)
Stefanos A. Tsiftsoglou
doaj   +1 more source

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Activation of the alternative complement pathway by Histoplasma capsulatum [PDF]

Infection and Immunity, 1980
The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 consumption was mediated by ...
J M Pepple, J A Winkelstein, W D Ratnoff
openaire   +3 more sources

Blood protein adsorption onto chitosan [PDF]

, 2002
Chitosan was recently indicated to enhance osteogenesis, improve wound healing but to activate the coagulation and the complement systems. In the present study approximately 10nm thick chitosan film were prepared on aminopropyltriethoxysilane (APTES ...
Benesch, Johan, Tengvall, P.
core   +1 more source