Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli [PDF]
Current Issues in Molecular Biology, 2021 In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ...
Maria G. Detsika, Elias A. Lianos
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Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion [PDF]
Frontiers in Microbiology, 2016 The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh +4 more
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Complement and complement regulatory proteins are upregulated in lungs of COVID-19 patients
Pathology - Research and Practice, 2023 We explored the pathological changes and the activation of local complement system in COVID-19 pneumonia. Lung paraffin sections of COVID-19 infected patients were analyzed by HE (hematoxylin-eosin) staining. The deposition of complement C3, the deposition of C3b/iC3b/C3d and C5b-9, and the expression of complement regulatory proteins, CD59, CD46 and ...
Xiaowen Ge +9 more
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Function of complement regulatory proteins in immunity of reproduction: a review [PDF]
Czech Journal of Animal Science, 2005 Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová +2 more
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Review: Complement and its regulatory proteins in kidney diseases [PDF]
Nephrology, 2010 ABSTRACTComplement is a part of the body's innate immune system that helps defend the host from microbial infection. It is tightly controlled by a number of cell surface and fluid‐phase proteins so that under normal circumstances injury to autologous tissues is avoided.
Allison M. Lesher, Wen‐Chao Song
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Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response [PDF]
Journal of NeuroinflammationBackground Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others ...
Alexander Kai Thomsen +7 more
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Chandipura virus evades human complement by recruiting host complement regulatory proteins
International Journal of Infectious Diseases, 2020 U. Kunnakkadan, J. Bernet Johnson
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Upregulation of complement proteins in lung cancer cells mediates tumor progression
Frontiers in Oncology, 2023 IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko +16 more
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Effect of Heme Oxygenase-1 Depletion on Complement Regulatory Proteins Expression in the Rat
Antioxidants, 2022 Heme oxygenase has been implicated in the regulation of various immune responses including complement activation. Using a transgenic rat model of HO-1 depletion, the present study assessed the effect of HO-1 absence on the expression of complement ...
Maria G. Detsika +4 more
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The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
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