Results 11 to 20 of about 305,892 (307)

Complement and complement regulatory proteins are upregulated in lungs of COVID-19 patients. [PDF]

Pathol Res Pract, 2023
We explored the pathological changes and the activation of local complement system in COVID-19 pneumonia. Lung paraffin sections of COVID-19 infected patients were analyzed by HE (hematoxylin-eosin) staining. The deposition of complement C3, the deposition of C3b/iC3b/C3d and C5b-9, and the expression of complement regulatory proteins, CD59, CD46 and ...
Ge X, Yu Z, Guo X, Li L, Ye L, Ye M, Yuan J, Zhu C, Hu W, Hou Y.   +9 more
europepmc   +4 more sources

Function of complement regulatory proteins in immunity of reproduction: a review [PDF]

Czech Journal of Animal Science, 2005
Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová, M. Simon, J. Antalíková   +2 more
doaj   +2 more sources

Complement proteins associated with circulatory and glomerular IgA-containing immune complexes in patients with IgA nephropathy [PDF]

Scientific Reports
IgA nephropathy (IgAN) is characterized by glomerular deposits of IgA-containing immune complexes (IgA-ICs), which are suspected to originate from circulation. However, the composition of these ICs is not fully understood.
Yudai Tsuji, Yukako Ohyama, Sei Saitoh, Tetsuro Enomoto, Masaya Hirayama, Hisateru Yamaguchi, Tomoki Nishioka, Tomohiro Mizuno, Naotake Tsuboi, Jan Novak, Kazuo Takahashi   +10 more
doaj   +2 more sources

The Role of Membrane Bound Complement Regulatory Proteins in Tumor Development and Cancer Immunotherapy. [PDF]

Front Immunol, 2019
Geller A, Yan J.
europepmc   +3 more sources

Altered Expression of Complement Regulatory Proteins CD35, CD46, CD55, and CD59 on Leukocyte Subsets in Individuals Suffering From Coronary Artery Disease. [PDF]

Front Immunol, 2019
Mishra N, Mohata M, Narang R, Lakshmy R, Hazarika A, Pandey RM, Das N, Luthra K.   +7 more
europepmc   +3 more sources

Chandipura virus evades human complement by recruiting host complement regulatory proteins

International Journal of Infectious Diseases, 2020
U. Kunnakkadan, J. Bernet Johnson
doaj   +2 more sources

Complement-regulatory proteins in ovarian malignancies [PDF]

International Journal of Cancer, 1997
Ovarian cancer has features that makes it well-suited for MAb adjuvant immunotherapy. Several of the MAbs used in clinical trials mediate cancer cell destruction by activation of complement (C). In this study, therefore, we examined the ability of ovarian-tumor cells to resist C attack.
Line Bjørge, Juha Hakulinen, Torsten Wahlström, Roald Matre, Seppo Meri   +4 more
openalex   +3 more sources

Combating Complement's Deleterious Effects on Nanomedicine by Conjugating Complement Regulatory Proteins to Nanoparticles. [PDF]

Adv Mater, 2022
AbstractComplement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and release of anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially
Wang Z, Hood ED, Nong J, Ding J, Marcos-Contreras OA, Glassman PM, Rubey KM, Zaleski M, Espy CL, Gullipali D, Miwa T, Muzykantov VR, Song WC, Myerson JW, Brenner JS.   +14 more
europepmc   +3 more sources

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
AG Barbour, AG Barbour, AG Barbour, AG Barbour, AS Coleman, C Neeleman, C Siegel, C Skerka, CA Brissette, Christiane Brenner, CS Brooks, D Raoult, David M. Ojcius, DJ Grab, E Rossmann, E Rossmann, GD Wieland, H Fuchs, J Bunikis, JA Gebbia, JC Scott, JC Setubal, JL Coleman, JV McDowell, K Hartmann, KM Hovis, KM Hovis, KO Sundnes, L Houhamdi, Markus M. Simon, MD Kramer, Melanie Schott, MK Pangburn, NM Ras, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Stewart, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, PM Southern, RD Horstmann, Reinhard Wallich, S Hammerschmidt, S Kuhn, S Kuhn, S Poltermann, S Ram, Sally J. Cutler, SH Rooijakkers, SJ Cutler, Sonja Grosskinsky, T Meri, T Meri, WR Zuckert   +59 more
core   +15 more sources

Upregulation of complement proteins in lung cancer cells mediates tumor progression

Frontiers in Oncology, 2023
IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko, Joanna M. Poczobutt, Andre C. Navarro, Jennifer Laskowski, Amber M. Johnson, Sean P. Korpela, Natalia J. Gurule, Lynn E. Heasley, Katharina Hopp, Mary C.M. Weiser-Evans, Elizabeth B. Gottlin, Ryan T. Bushey, Michael J. Campa, Edward F. Patz, Edward F. Patz, Joshua M. Thurman, Raphael A. Nemenoff   +16 more
doaj   +1 more source