Results 11 to 20 of about 1,176 (261)

Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion

Frontiers in Immunology, 2023
Background and aimsComplement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis.Materials and ...
Huan Tang, Huan Tang, Xinyue Hu, Xinyue Hu, Li Li, Shuanglinzi Deng, Shuanglinzi Deng, Yuanyuan Jiang, Yuanyuan Jiang, Lisha Luo, Lisha Luo, Runjin Cai, Runjin Cai, Yifei Yang, Yifei Yang, Chendong Wu, Chendong Wu, Xiaoxiao Gong, Xiaoxiao Gong, Juntao Feng, Juntao Feng   +20 more
doaj   +1 more source

Laboratory tests for disorders of complement and complement regulatory proteins [PDF]

American Journal of Hematology, 2015
The complement pathway is a cascade of proteases that is involved in immune surveillance and innate immunity, as well as adaptive immunity. Dysfunction of the complement cascade may be mediated by aberrations in the pathways of activation, complement regulatory proteins, or complement deficiencies, and has been linked to a number of hematologic ...
Mandakolathur R. Murali, Angela R. Shih
openaire   +3 more sources

Genetic engineering strategies to prevent the effects of antibody and complement on xenogeneic chondrocytes [PDF]

European Cells & Materials, 2015
Advances in animal transgenesis may allow using xenogeneic chondrocytes in tissue-engineering applications for clinical cartilage repair. Porcine cartilage is rejected by humoral and cellular mechanisms that could be overcome by identifying key molecules
R Sommaggio, D Bello-Gil, M Pérez-Cruz, JL Brokaw, R Máñez, C Costa   +5 more
doaj   +1 more source

Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies

Frontiers in Pharmacology, 2022
Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases.
Loveleena Bansal, Eva-Maria Nichols, Daniel P. Howsmon, Jessica Neisen, Christina M. Bessant, Fraser Cunningham, Sebastien Petit-Frere, Steve Ludbrook, Valeriu Damian   +8 more
doaj   +1 more source

Virus-Encoded Complement Regulators: Current Status

Viruses, 2021
Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha, Anup Kumar Singh, Trupti Satish Kadni, Jayati Mullick, Arvind Sahu   +4 more
doaj   +1 more source

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

Frontiers in Immunology, 2022
Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement.
Kelly C. Fahnoe, Fei Liu, Jennifer G. Morgan, Sarah T. Ryan, Michael Storek, Ellen Garber Stark, Fred R. Taylor, V. Michael Holers, Joshua M. Thurman, Stefan Wawersik, Susan L. Kalled, Shelia M. Violette   +11 more
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The effect of splenectomy on complement regulatory proteins in erythrocytes in β-thalassemia major

Archives of Medical Science, 2018
Introduction Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major (β-TM) patients. The role of complement system in the etiopathogenesis of hemolysis observed in β-TM were released.
Ayşegül Uğur Kurtoğllu, Belkıs Koçtekin, Erdal Kurtoğlu, Mustafa Yildiz   +3 more
doaj   +1 more source

Binding of complement regulatory proteins to Group A Streptococcus [PDF]

Vaccine, 2008
Streptococcus pyogenes or Group A Streptococcus (GAS) is the etiologic agent of important human infections such as acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Binding of the complement regulatory proteins factor H, factor H-like protein 1 (FHL-1), C4b-binding protein (C4BP), or CD46 is a crucial step in the ...
Oliver, María Antonia, Rojo, José María, Rodríguez de Córdoba, Santiago, Albertí, Sebastián   +3 more
openaire   +4 more sources

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. [PDF]

PLoS ONE, 2017
Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement ...
Mark T Winkler, Ryan T Bushey, Elizabeth B Gottlin, Michael J Campa, Eross S Guadalupe, Alicia D Volkheimer, J Brice Weinberg, Edward F Patz   +7 more
doaj   +1 more source

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

Malaria Journal, 2019
Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an ...
Damian A. Oyong, Jessica R. Loughland, Arya SheelaNair, Dean Andrew, Fabian D. L. Rivera, Kim A. Piera, Timothy William, Matthew J. Grigg, Bridget E. Barber, Ashraful Haque, Christian R. Engwerda, James S. McCarthy, Nicholas M. Anstey, Michelle J. Boyle   +13 more
doaj   +1 more source