The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
doaj +1 more source
Genetic engineering strategies to prevent the effects of antibody and complement on xenogeneic chondrocytes [PDF]
European Cells & Materials, 2015 Advances in animal transgenesis may allow using xenogeneic chondrocytes in tissue-engineering applications for clinical cartilage repair. Porcine cartilage is rejected by humoral and cellular mechanisms that could be overcome by identifying key molecules
R Sommaggio +5 more
doaj +1 more source
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
Frontiers in Pharmacology, 2022 Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases.
Loveleena Bansal +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement.
Kelly C. Fahnoe +11 more
doaj +1 more source
Review: Complement and its regulatory proteins in kidney diseases [PDF]
Nephrology, 2010 ABSTRACTComplement is a part of the body's innate immune system that helps defend the host from microbial infection. It is tightly controlled by a number of cell surface and fluid‐phase proteins so that under normal circumstances injury to autologous tissues is avoided.
Allison M. Lesher, Wen‐Chao Song
openalex +3 more sources
Virus-Encoded Complement Regulators: Current Status
Viruses, 2021 Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha +4 more
doaj +1 more source
Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. [PDF]
PLoS ONE, 2017 Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement ...
Mark T Winkler +7 more
doaj +1 more source
Role of complement and complement regulatory proteins in the complications of diabetes.
Endocr Rev, 2015 It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood.
Ghosh P +4 more
europepmc +4 more sources
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]
, 2016 Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic +83 more
core +3 more sources