Results 21 to 30 of about 1,176 (261)
The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59 [PDF]
Journal of Biological Chemistry, 1997 Human erythrocyte CD59 contains N- and O-glycans and a glycosylphosphatidylinositol (GPI) anchor, all of which have been analyzed in this study. The anchor consists principally of the minimum core glycan sequence Manalpha1-2Manalpha1-6Manalpha1-4GlcN-linked to a phosphatidylinositol moiety with the structure sn-1-O-alkyl(C18:0 and C18:1)-2-O-acyl(C20:4)
Rudd, P +7 more
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Frontiers in Molecular Neuroscience, 2021 Complement, a feature of the innate immune system that targets pathogens for phagocytic clearance and promotes inflammation, is tightly regulated to prevent damage to host tissue.
Nicholas Peoples, Candace Strang
doaj +1 more source
Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
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Complement regulatory proteins in glomerular diseases [PDF]
Kidney International, 1998 Complement activation plays a critical role in the pathogenesis of many forms of glomerulonephritis. Complement activation leads to tissue injury through various mechanisms including the generation of chemotactic factors and activation of the resident glomerular cells following C5b-9 insertion.
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Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein [PDF]
Journal of Virology, 2005 ABSTRACTVaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the ...
Jayati Mullick +5 more
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Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host
Frontiers in Microbiology, 2019 Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao +4 more
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Role of Complement and Complement Regulatory Proteins in the Complications of Diabetes
Endocrine Reviews, 2015 It is well established that the organ damage that complicates human diabetes is caused by prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels of glucose cause tissue damage in humans are still not fully understood.
Rupam Sahoo +4 more
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Involvement of the complement system in immune thrombocytopenia: review of the literature
Immunological Medicine, 2023 Immune thrombocytopenia (ITP) is a thrombocytopenic condition induced by autoimmune mechanisms and includes secondary ITP with underlying diseases such as connective tissue diseases (CTD).
Risa Shindo +10 more
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On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2013 It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the
Leonardo P Farias +11 more
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Frontiers in Immunology, 2022 Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma.
Alexandra Gerogianni +20 more
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