Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study [PDF]
Encephalitis, 2023 Purpose We evaluated the associations between serum complement levels and tuberculous meningitis (TBM), bacterial meningitis (BM), and viral meningitis (VM), as well as the association between serum complement levels and mortality in TBM.
Hansol Im +7 more
doaj +1 more source
Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D. [PDF]
Commun BiolRecent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D).
Hu X +10 more
europepmc +2 more sources
Comprehensive review of membranoproliferative glomerulonephritis: spotlighting the latest advances in revised classification and treatment [PDF]
Childhood Kidney Diseases, 2023 Membranoproliferative glomerulonephritis (MPGN) is a complex group of renal diseases characterized by a specific pattern of glomerular injury that includes thickening of the capillary wall and mesangial expansion, leading to a heterogeneous group of ...
Jeong Yeon Kim
doaj +1 more source
The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
doaj +1 more source
Dysregulation of complement system in neuropsychiatric disorders: A mini review
Biomarkers in Neuropsychiatry, 2022 Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation
Danny Perez Sierra +2 more
doaj +1 more source
Virus-Encoded Complement Regulators: Current Status
Viruses, 2021 Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha +4 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 As part of the innate immune system, complement plays a critical role in the elimination of pathogens and mobilization of cellular immune responses. In the central nervous system (CNS), many complement proteins are locally produced and regulate nervous ...
Noriko Shinjyo +4 more
doaj +1 more source
Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
doaj +1 more source
Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host
Frontiers in Microbiology, 2019 Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao +4 more
doaj +1 more source