Results 11 to 20 of about 533,270 (282)

Virus-Encoded Complement Regulators: Current Status

Viruses, 2021
Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha, Anup Kumar Singh, Trupti Satish Kadni, Jayati Mullick, Arvind Sahu   +4 more
doaj   +1 more source

Different Complement Activation Pathways Underly Cognitive Impairment and Type 2 Diabetes Mellitus Combined With Cognitive Impairment

Frontiers in Aging Neuroscience, 2022
BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li, Weiwei Zhang, Feng Gao, Feng Gao, Qiqiang Tang, Dongmei Kang, Yong Shen, Yong Shen   +7 more
doaj   +1 more source

Interaction Between the Complement System and Infectious Agents – A Potential Mechanistic Link to Neurodegeneration and Dementia

Frontiers in Cellular Neuroscience, 2021
As part of the innate immune system, complement plays a critical role in the elimination of pathogens and mobilization of cellular immune responses. In the central nervous system (CNS), many complement proteins are locally produced and regulate nervous ...
Noriko Shinjyo, Noriko Shinjyo, Wataru Kagaya, Marcela Pekna, Marcela Pekna   +4 more
doaj   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
AG Barbour, AG Barbour, AG Barbour, AG Barbour, AS Coleman, C Neeleman, C Siegel, C Skerka, CA Brissette, Christiane Brenner, CS Brooks, D Raoult, David M. Ojcius, DJ Grab, E Rossmann, E Rossmann, GD Wieland, H Fuchs, J Bunikis, JA Gebbia, JC Scott, JC Setubal, JL Coleman, JV McDowell, K Hartmann, KM Hovis, KM Hovis, KO Sundnes, L Houhamdi, Markus M. Simon, MD Kramer, Melanie Schott, MK Pangburn, NM Ras, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Stewart, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, PM Southern, RD Horstmann, Reinhard Wallich, S Hammerschmidt, S Kuhn, S Kuhn, S Poltermann, S Ram, Sally J. Cutler, SH Rooijakkers, SJ Cutler, Sonja Grosskinsky, T Meri, T Meri, WR Zuckert   +59 more
core   +11 more sources

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear

Frontiers in Cellular and Infection Microbiology, 2020
Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the ...
Mohammed Razeeth Shait Mohammed, Sandhya Krishnan, Rabbind Singh Amrathlal, Jeya Maheshwari Jayapal, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu   +6 more
doaj   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source