Results 11 to 20 of about 2,132,131 (391)

Dynamic control of the complement system by modulated expression of regulatory proteins [PDF]

Laboratory Investigation, 2011
The complement system serves many biological functions, including the eradication of invasive pathogens and the removal of damaged cells and immune-complexes. Uncontrolled complement activation causes injury to host cells, however, so adequate regulation of the system is essential.
Brandon Renner, Joshua M. Thurman
semanticscholar   +6 more sources

Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response [PDF]

Frontiers in Immunology, 2017
The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate in microbial detection, which ultimately results in the
Upasana Shokal, Ioannis Eleftherianos
openalex   +2 more sources

IMMUNOLOGICAL STUDIES OF THE 11S PROTEIN COMPONENT OF THE HUMAN COMPLEMENT SYSTEM [PDF]

The Journal of Experimental Medicine, 1964
Rabbit anticryoprotein and anticomplement antisera recognized a heat-labile antigen in normal human serum. This antigen best fitted the previously described US protein because of its presence in fresh human serum, euglobulin, and purified 11S preparations and its absence in heated serum, R11S, and pseudoglobulin preparations. The 11S hemolytic activity
Jane H. Morse, Charles L. Christian
openaire   +4 more sources

Lectin pathway proteins of the complement system in normotensive pregnancy and pre‐eclampsia [PDF]

American Journal of Reproductive Immunology, 2019
ProblemThe lectin pathway of the complement system may be involved in the pathogenesis of pre‐eclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with pre‐eclampsia, placental infarctions and intrauterine growth restriction (IUGR).Method of studyWe ...
Michael R. Lassen, Julie Brogaard Larsen, Christine Lodberg Hvas, Anita Sylvest Andersen, Steffen Thiel, Anne-Mette Hvas, Anne-Mette Hvas, Anette Tarp Hansen, Anette Tarp Hansen   +8 more
openaire   +5 more sources

Role of the complement system in the tumor microenvironment

Cancer Cell International, 2019
The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (
Ronghua Zhang, Qiaofei Liu, Tong Li, Quan Liao, Yupei Zhao   +4 more
doaj   +2 more sources

INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM [PDF]

The Journal of Experimental Medicine, 1974
Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37°C, 0.10 M relative salt ...
Henry Gewurz, Joan N. Siegel, Rosemarie Rent   +2 more
openaire   +4 more sources

Proteins of the lectin pathway of the complement system activation: immunobiological functions, genetics and involvement in the pathogenesis of human diseases

Инфекция и иммунитет, 2022
The complement system is the most ancient components in the innate immunity, mainly functioning to primarily eliminate bacterial agents intravascularly.
Marina V. Smolnikova, Sergey Yu. Tereshchenko   +1 more
doaj   +3 more sources

Dysregulation of Complement System in Neuropsychiatric Disorders: A Mini Review [PDF]

Biomarkers in Neuropsychiatry, 2022
Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation
Pillai, Anilkumar, Sierra, Danny Perez, Tripathi, Ashutosh   +2 more
core   +3 more sources

Factor H family proteins in complement evasion of microorganisms [PDF]

Frontiers in Immunology, 2017
Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Agarwal, Agarwal, Behnsen, Blaum, Caesar, Castiblanco-Valencia, Chen, Clark, Csincsi, Davila, Eberhardt, Ermert, Fine, Friberg, Fritsche, Goicoechea de Jorge, Granoff, Gropp, Gustafsson, Hammerschmidt, Haupt, Haupt, Hebecker, Hebecker, Heinen, Hellwage, Hellwage, Hellwage, Horstmann, Hovis, Janulczyk, Józsi, Józsi, Józsi, Kajander, Kishore, Kopp, Kraiczy, Kunert, Lambris, Langereis, Losse, McDowell, McRae, Medjeral-Thomas, Meri, Meri, Merle, Mihlan, Miller, Miller, Morgan, Mészáros, Ngampasutadol, Närkiö-Mäkelä, Parente, Pizza, Pouw, Ram, Ram, Ren, Reuter, Ricklin, Riva, Rosa, Schmidt, Schneider, Schneider, Schneider, Schäfer, Seib, Siegel, Strobel, Sun, Svoboda, Tan, Tortajada, Vik, Wu, Zipfel, Zipfel   +80 more
core   +4 more sources

Interactions of C-reactive protein with the complement system. III. Complement-dependent passive hemolysis initiated by CRP. [PDF]

The Journal of experimental medicine, 1975
Interactions of CRP with various substrates in the presence of human serum have been shown to result in efficient activation of C components C1-C5. We now report the ability of CRP to initiate C-dependent hemolysis. For this purpose CRP was isolated by affinity chromatography using pneumococcal CPS and gel filtration; its purity was established by ...
R F Mortensen, Joan N. Siegel, A P Osmand, Henry Gewurz   +3 more
openaire   +4 more sources