Results 31 to 40 of about 2,103,871 (307)

Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host

Frontiers in Microbiology, 2019
Parasitic infections induce host immune responses that eliminate the invading parasites. However, parasites have evolved to develop many strategies to evade host immune attacks and survive in a hostile environment. The complement system acts as the first
Shuai Shao, Ximeng Sun, Yi Chen, Bin Zhan, Xinping Zhu   +4 more
doaj   +1 more source

Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear

Frontiers in Cellular and Infection Microbiology, 2020
Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the ...
Mohammed Razeeth Shait Mohammed, Sandhya Krishnan, Rabbind Singh Amrathlal, Jeya Maheshwari Jayapal, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu   +6 more
doaj   +1 more source

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

Frontiers in Immunology, 2021
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe ...
Youssif M. Ali, Matteo Ferrari, N. Lynch, S. Yaseen, T. Dudler, Sasha Gragerov, G. Demopulos, J. Heeney, W. Schwaeble   +8 more
semanticscholar   +1 more source

The role of complement in ocular pathology [PDF]

, 2008
Functionally active complement system and complement regulatory proteins are present in the normal human and rodent eye. Complement activation and its regulation by ocular complement regulatory proteins contribute to the pathology of various ocular ...
A Nicholson-Weller, AE Davis 3rd, AM Blom, AO Edwards, AP Spicer, B Gold, B Li, BE Prosser, BJ Mondino, BJ Mondino, BJ Mondino, BJ Mondino, BJ Mondino, BJ Mondino, BJ Mondino, BJ Mondino, BJ Mondino, BP Morgan, BP Morgan, C Verhagen, D Husain, DM Lublin, DS Bardenstein, DS Bardenstein, DS Gregerson, E Cocuzzi, EF Foxman, FL Ferris, GE Marak, GS Hageman, H Kimura, H Miller, H Takizawa, HJ Muller-Eberhard, I Bykov, J Maller, JH Lass, JH Sohn, JH Sohn, JH Sohn, JJ Alexander, JJ Diehn, JL Haines, JP Atkinson, JP Atkinson, JR Yates, JR Yates, JT Rosenbaum, JY Niederkorn, JZ Nowak, K Funabashi, KBM Reid, LD Hazlett, LV Johnson, LV Johnson, M Krych-Goldberg, M Laine, M Liu, M Nonaka, M Nozaki, MB Powell, MD Willcox, MH Holguin, MJ Watts, MK Liszewski, MK Liszewski, MK Liszewski, MM Frank, MN Mandal, MW Nickells, Nalini S. Bora, NS Bora, NS Bora, NS Bora, NS Bora, NS Bora, P Jha, P Jha, P Jha, PJ Coffey, PS Bora, PS Bora, PS Bora, Puran S. Bora, Purushottam Jha, RA Prendergast, RB Nussenblatt, RF Mullins, RJ Klein, RP Cleveland, RR Caspi, RR Kew, RW Read, S Sivaprasad, SF Wheeler, SJ Ryan, T Miwa, U Pleyer, V Montalvo, Y Bando, YM Qian, YU Kim   +101 more
core   +2 more sources

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response

Frontiers in Immunology, 2017
The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate in microbial detection, which ultimately results in the
U. Shokal, I. Eleftherianos
semanticscholar   +1 more source

Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis [PDF]

Proteomics 3 (03/2003) 249-53, 2006
The solubilizing power of various nonionic and zwitterionic detergents as membrane protein solubilizers for two-dimensional electrophoresis was investigated. Human red blood cell ghosts and Arabidopsis thaliana leaf membrane proteins were used as model systems. Efficient detergents could be found in each class, i.e.
arxiv   +1 more source

Human complement control and complement evasion by pathogenic microbes - Tipping the balance [PDF]

, 2013
Complement is a central homeotic system of mammals and represents the first defense line of innate immunity. The human complement system is aimed to maintain homeostasis by recognizing and removing damaged or modified self material, as well as infectious
Hallstroem, Teresia, Riesbeck, Kristian, Zipfel, Peter F.   +2 more
core   +1 more source

Counterion-release entropy governs the inhibition of serum proteins by polyelectrolyte drugs [PDF]

Biomacromolecules, 2018, 19 (2), pp 409-416, 2017
Dendritic polyelectrolytes constitute high potential drugs and carrier systems for biomedical purposes, still their biomolecular interaction modes, in particular those determining the binding affinity to proteins, have not been rationalized. We study the interaction of the drug candidate dendritic polyglycerol sulfate (dPGS) with serum proteins using ...
arxiv   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources