Results 41 to 50 of about 2,103,871 (307)

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

Frontiers in Microbiology, 2016
The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh, Elise Sofie Hovingh, Bryan van den Broek, Ilse Jongerius, Ilse Jongerius   +4 more
doaj   +1 more source

Complement proteins in unexpected places: why we should be excited, not concerned! [version 1; peer review: 2 approved]

F1000Research, 2020
The complement system consists of more than 30 plasma as well as cell surface proteins that together constitute a major arm of the immune system. The long-held belief is that most of the complement components are synthesized by hepatocytes in the liver ...
Berhane Ghebrehiwet
doaj   +1 more source

Bilayer-thickness-mediated interactions between integral membrane proteins [PDF]

Phys. Rev. E 93, 042410 (2016), 2016
Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations can yield energetically favorable bilayer-mediated interactions between integral membrane proteins, and large ...
arxiv   +1 more source

Factor H family proteins and human diseases [PDF]

, 2008
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Abrera-Abeleda, Anderson, Appel, Behnsen, Caswell, Coffey, Corbett, Cordes, Crabb, Dragon-Durey, Ferreira, Gold, Hageman, Hageman, Hammerschmidt, Haupt, Heinen, Hellwage, Hellwage, Hellwage, Hughes, Høgåsen, Jokiranta, Józsi, Józsi, Józsi, Józsi, Kavanagh, Klein, Kotarsky, Kotarsky, Kraiczy, Kunert, Laine, Lambris, Licht, Manuelian, Markiewski, McArthur, McDowell, McRae, Mihály Józsi, Montalvo, Monteferrante, Murphy, Ngampasutadol, Noris, Nozaki, Närkiö-Mäkelä, Oppermann, Pandiripally, Park, Peter F. Zipfel, Pickering, Pickering, Prodinger, Ren, Rodríguez de Córdoba, Skerka, Skerka, Stevenson, Timmann, Venables, Verma, Vik, Walport, Yates, Zipfel, Zipfel, Zipfel   +69 more
core   +1 more source

Simulating the chromatin mediated phase separation of model proteins with multiple domains [PDF]

, 2021
We perform simulations of a system containing simple model proteins and a polymer representing chromatin. We study the interplay between protein-protein and protein-chromatin interactions, and the resulting condensates which arise due to liquid-liquid phase separation, or a via a 'bridging-induced attraction' mechanism.
arxiv   +1 more source

The significance of the complement system for the pathogenesis of age-related macular degeneration — current evidence and translation into clinical application [PDF]

, 2010
BACKGROUND: Dysregulation of the complement system has been shown to play a major role in the pathogenesis of age-related macular degeneration (AMD). METHODS: The current evidence from human studies derives from immunohistochemical and proteomic studies ...
A Farwick, A Laude, A Swaroop, A Thakkinstian, A Tortajada, AE Hughes, AE Hughes, Age-Related Eye Disease Study Research Group, AL Wang, AO Edwards, AP Ciardella, AP Herbert, AP Sjoberg, AY Lee, B Chua, BJ Wegscheider, C Skerka, CC Klaver, CE McAvoy, CJ Boon, CJ Boon, D Nitsch, DA Schaumberg, DD Despriet, DH Anderson, DH Anderson, E Cho, E Wagner, EWT Chong, GS Hageman, GS Hageman, GS Hageman, H Chen, H Hayashi, Hendrik P. N. Scholl, HP Scholl, HPN Scholl, HPN Scholl, HR Coleman, IM Heiba, J Duvall-Young, J Duvall-Young, J Jakobsdottir, J Yu, J Zhou, JA Fagerness, JB Maller, JG Hollyfield, JJ Wang, JL Haines, JM Seddon, JM Seddon, JM Seddon, JM Seddon, JM Seddon, JM Thurman, JR Dunkelberger, JR Yates, JW Crabb, KL Spencer, KL Spencer, KP Magnusson, KY Lee, L Luo, LA Hecker, LH Lima, LV Johnson, M Chen, M Chen, M Laine, MA Brantley Jr, MA Brantley Jr, MA Brantley Jr, MA Grassi, MJ Walport, ML Klein, ML Klein, MM DeAngelis, MT Andreoli, N Kondo, N Leveziel, N Leveziel, N. Victor Chong, P Charbel Issa, Peter Charbel Issa, PF Zipfel, PJ Coffey, PJ Francis, PJ Francis, PN Baird, PT Jong de, R Reynolds, RD Jager, RF Mullins, RF Mullins, RJ Klein, RJ Ormsby, RK Shuler Jr, RO Schlingemann, S Ennis, S Haddad, S Hakobyan, S Katta, S Wasmuth, SJ Clark, SJ Clark, SP Seitsonen, SV Goverdhan, T Sepp, TE Mollnes, U Kelly, W Smith, X Ding, X Feng, X Yuan, YP Conley   +115 more
core   +2 more sources

Amino acid balancing for the prediction and evaluation of protein concentrations in cell-free protein synthesis systems [PDF]

arXiv, 2023
Cell-free protein synthesis (CFPS) systems are an attractive to complement the usual cell-based synthesis of proteins, especially for screening approaches. The literature describes a wide variety of CFPS systems, but their performance is difficult to compare since the reaction components are often used at different concentrations.
arxiv  

Complement as a regulator of adaptive immunity [PDF]

, 2017
International audienceThe complement system is an ancient and evolutionarily conserved effector system comprising in mammals over 50 circulating and membrane bound proteins.
Astier, Anne, Killick, Justin, Morisse, Gregoire, Sieger, Dirk   +3 more
core   +2 more sources

Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway

Frontiers in Microbiology, 2017
The complement system is a crucial defensive network that protects the host against invading pathogens. It is part of the innate immune system and can be initiated via three pathways: the lectin, classical and alternative activation pathway.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Peter Garred   +3 more
doaj   +1 more source

Precision Medicine in Neurology: The Inspirational Paradigm of Complement Therapeutics

Pharmaceuticals, 2020
Precision medicine has emerged as a central element of healthcare science. Complement, a component of innate immunity known for centuries, has been implicated in the pathophysiology of numerous incurable neurological diseases, emerging as a potential ...
Maria Gavriilaki, Vasilios K. Kimiskidis, Eleni Gavriilaki   +2 more
doaj   +1 more source