Role of the complement system in the tumor microenvironment
Cancer Cell International, 2019 The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (
Ronghua Zhang +4 more
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F1000Research, 2020 The complement system consists of more than 30 plasma as well as cell surface proteins that together constitute a major arm of the immune system. The long-held belief is that most of the complement components are synthesized by hepatocytes in the liver ...
Berhane Ghebrehiwet
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Electrostatic Steering Accelerates C3d:CR2 Association. [PDF]
, 2016 Electrostatic effects are ubiquitous in protein interactions and are found to be pervasive in the complement system as well. The interaction between complement fragment C3d and complement receptor 2 (CR2) has evolved to become a link between innate and ...
Dimitrios Morikis +4 more
core +2 more sources
Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis [PDF]
, 1979 Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and
Barz, D. +3 more
core +1 more source
Characterization of serum proteins attached to distinct sol–gel hybrid surfaces [PDF]
, 2017 The success of a dental implant depends on its osseointegration, an important feature of the implant biocompatibility. In this study, two distinct sol–gel hybrid coating formulations [50% methyltrimethoxysilane: 50% 3-glycidoxypropyl-trimethoxysilane ...
Azkargorta, Mikel +9 more
core +2 more sources
Precision Medicine in Neurology: The Inspirational Paradigm of Complement Therapeutics
Pharmaceuticals, 2020 Precision medicine has emerged as a central element of healthcare science. Complement, a component of innate immunity known for centuries, has been implicated in the pathophysiology of numerous incurable neurological diseases, emerging as a potential ...
Maria Gavriilaki +2 more
doaj +1 more source
SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems
Frontiers in Immunology, 2021 Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute ...
Anne G. Savitt +13 more
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Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway
Frontiers in Microbiology, 2017 The complement system is a crucial defensive network that protects the host against invading pathogens. It is part of the innate immune system and can be initiated via three pathways: the lectin, classical and alternative activation pathway.
Anne Rosbjerg +3 more
doaj +1 more source
Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region [PDF]
, 2017 The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases.
De Pablos, Luis Miguel +5 more
core +3 more sources
Lectin pathway proteins of the complement system in normotensive pregnancy and pre‐eclampsia [PDF]
American Journal of Reproductive Immunology, 2019 ProblemThe lectin pathway of the complement system may be involved in the pathogenesis of pre‐eclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with pre‐eclampsia, placental infarctions and intrauterine growth restriction (IUGR).Method of studyWe ...
Julie Brogaard Larsen +6 more
openaire +3 more sources