Folia VeterinariaNeuroinfections are difficult and time-consuming to treat. The main bottleneck in therapy is drugs’ inability to enter the central nervous system (CNS) via the blood-brain barrier (BBB).
Talpašová Lea +3 more
doaj +2 more sources
Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity. [PDF]
J Clin Invest, 2010 Pemphigus is a life-threatening autoimmune disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte cell adhesion and blisters. In order to understand how antibodies cause pathogenicity and whether there are commonalities among antibodies in different patients that could ultimately be used to target specific therapy ...
Yamagami J +5 more
europepmc +4 more sources
Translational Oncology, 2021 Uterine cancer has been associated with a T-cell immune response that leads to increased survival. Therefore, we used several bioinformatics approaches to explore specific interactions between T-cell receptor (TCR) and tumor mutant peptide sequences ...
Monica Hsiang +8 more
doaj +1 more source
Viruses, 2023 Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an ongoing pandemic that continues to evolve and reinfect individuals. To understand the convergent antibody responses that evolved over the course of the pandemic, we evaluated the ...
Kate J. Liu +2 more
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Characteristics and Clinical Significance of T-Cell Receptor Repertoire in Hepatocellular Carcinoma
Frontiers in Immunology, 2022 Several studies have demonstrated that the T-cell receptor (TCR) repertoire is associated with prognosis and immune therapy response in several types of cancer. However, the comprehensive features of TCR repertoire in tumor-infiltrating and circulating T
Zifei Wang +23 more
doaj +1 more source
Complementarity-Determining Region 3 Spectratyping Analysis of the TCR Repertoire in Multiple Sclerosis [PDF]
The Journal of Immunology, 2003 Abstract Multiple sclerosis (MS) is considered to be an autoimmune disease mediated by T cells reactive with Ags in the CNS. Therefore, it has been postulated that neuroantigen-reactive T cells bearing particular types of TCRs are expanded clonally during the course of the disease.
Yoh, Matsumoto +7 more
openaire +2 more sources
High‐throughput sequencing reveals the change of TCR α chain CDR3 with Takayasu arteritis
Immunity, Inflammation and Disease, 2023 Objective Takayasu arteritis (TAK) is an inflammatory disease of blood vessels, and its pathogenesis is not clear at present. In this study, we explored the immunological characteristics of T cell receptor (TCR) α‐chain complementarity‐determining region
Bowen Zha, Lili Pan, Na Gao
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Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells [PDF]
Frontiers of Agricultural Science and Engineering, 2014 In the bone marrow and spleen, the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire.
Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO
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Selection of Ig μ Heavy Chains by Complementarity-Determining Region 3 Length and Amino Acid Composition [PDF]
The Journal of Immunology, 2003 Abstract Although it is generally accepted that Ig heavy chains (HC) are selected at the pre-B cell receptor (pre-BCR) checkpoint, the characteristics of a functional HC and the role of pre-BCR assembly in their selection have remained elusive. We determined the characteristics of HCs that successfully passed the pre-BCR checkpoint by
Denise A, Martin +5 more
openaire +2 more sources
Characterization and role in experimental systemic lupus erythematosus of T‐cell lines specific to peptides based on complementarity‐determining region‐1 and complementarity‐determining region‐3 of a pathogenic anti‐DNA monoclonal antibody [PDF]
Immunology, 2000 SummaryPeptides based on the complementarity‐determining region 1 (CDR1) and CDR3 of an anti‐DNA monoclonal antibody (mAb) carrying the 16/6 idiotype (Id) were shown to induce experimental systemic lupus erythematosus (SLE) in susceptible mouse strains. In the present study, T‐cell lines specific to the pCDR1 and pCDR3 peptides were established in BALB/
N, Brosh, E, Eilat, H, Zinger, E, Mozes
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